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Top Articles

#TitleJournalYearCitations
1Angiotensin-converting enzyme 2 protects from severe acute lung failureNature20052,264
2Evidence for osteocyte regulation of bone homeostasis through RANKL expressionNature Medicine20111,593
3Autophagy in malignant transformation and cancer progressionEMBO Journal20151,012
4Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTENNature2006880
5Essential versus accessory aspects of cell death: recommendations of the NCCD 2015Cell Death and Differentiation2015811
6Regulation of cancer cell migration and bone metastasis by RANKLNature2006709
7Fluorogenic probes for live-cell imaging of the cytoskeletonNature Methods2014705
8AIF deficiency compromises oxidative phosphorylationEMBO Journal2004576
9Neural Circuitry that Governs Drosophila Male Courtship BehaviorCell2005515
10A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesisNature Cell Biology2009437
11fruitless Splicing Specifies Male Courtship Behavior in DrosophilaCell2005423
12Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters2010400
13Identification and functional analysis of endothelial tip cell–enriched genesBlood2010379
14Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsNature Medicine2006378
15The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural ProgenitorsCell2009372
16A dual role for autophagy in a murine model of lung cancerNature Communications2014369
17The DrosDel CollectionGenetics2004342
18Cleavage of the siRNA passenger strand during RISC assembly in human cellsEMBO Reports2006340
19Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human SubjectsClinical Pharmacokinetics2013326
20Seventy-five genetic loci influencing the human red blood cellNature2012320
21Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cellsNature Cell Biology2010315
22The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptorsNature Immunology2007300
23LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorptionNature Medicine2016278
24Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial InfectionScience2009277
25Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human PlacentaStem Cell Reports2018273
26Functional Recovery of a Human Neonatal Heart After Severe Myocardial InfarctionCirculation Research2016272
27Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure OverloadCirculation Research2007260
28Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injuryScientific Reports2014249
29CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral OriginAmerican Journal of Respiratory and Critical Care Medicine2013248
30Function of the Drosophila CPEB protein Orb2 in long-term courtship memoryNature Neuroscience2007234
31Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin ResistanceJournal of Biological Chemistry2011224
32Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cellsEmerging Microbes and Infections2020221
33Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110γ and p110δ, in Lymphocyte Chemotaxis and HomingJournal of Immunology2004217
34Filopodia Formation in the Absence of Functional WAVE- and Arp2/3-ComplexesMolecular Biology of the Cell2006212
35The Arabidopsis HEI10 Is a New ZMM Protein Related to Zip3PLoS Genetics2012208
36ADF/Cofilin-Mediated Actin Retrograde Flow Directs Neurite Formation in the Developing BrainNeuron2012198
37ACE2 – From the renin–angiotensin system to gut microbiota and malnutritionMicrobes and Infection2013193
38ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced ObesityDiabetes2016193
39Three-Dimensional Model of Salmonella ’s Needle Complex at Subnanometer ResolutionScience2011182
40Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell frontNature Cell Biology2008180
41The Role of Iron Regulation in Immunometabolism and Immune-Related DiseaseFrontiers in Molecular Biosciences2019178
42JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortalityScience Advances2021176
43The metabolite BH4 controls T cell proliferation in autoimmunity and cancerNature2018174
44Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin AnaloguesJournal of the American Heart Association2013171
45Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamellaJournal of Cell Biology2008169
46Structure of a pathogenic type 3 secretion system in actionNature Structural and Molecular Biology2014166
47The comings and goings of actin: coupling protrusion and retraction in cell motilityCurrent Opinion in Cell Biology2005158
48AIF: Not Just an Apoptosis‐Inducing FactorAnnals of the New York Academy of Sciences2009151
49Cofilin cooperates with fascin to disassemble filopodial actin filamentsJournal of Cell Science2011146
50Identification of cell cycle–arrested quiescent osteoclast precursors in vivoJournal of Cell Biology2009144