# | Title | Journal | Year | Citations |
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1 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
2 | Activated human T cells directly induce osteoclastogenesis from human monocytes: Possible role of T cells in bone destruction in rheumatoid arthritis patients | Arthritis and Rheumatism | 2001 | 577 |
3 | Comparison of Disease Activity Score (DAS)28- erythrocyte sedimentation rate and DAS28- C-reactive protein threshold values | Annals of the Rheumatic Diseases | 2007 | 340 |
4 | Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association Studies | American Journal of Human Genetics | 2008 | 327 |
5 | Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 324 |
6 | Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population | Nature Genetics | 2012 | 285 |
7 | Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis | Rheumatology | 2010 | 261 |
8 | Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis | Rheumatology | 2012 | 261 |
9 | Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses | Pharmacogenetics and Genomics | 2002 | 248 |
10 | Japanese Guideline for the Management of Hyperuricemia and Gout: Second Edition | Nucleosides, Nucleotides and Nucleic Acids | 2011 | 244 |
11 | A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility | Nature Genetics | 2010 | 241 |
12 | Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee | Knee | 2003 | 238 |
13 | Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy | Annals of the Rheumatic Diseases | 2012 | 220 |
14 | Variations in the FTO gene are associated with severe obesity in the Japanese | Journal of Human Genetics | 2008 | 219 |
15 | Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study | Arthritis Research and Therapy | 2010 | 217 |
16 | Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis | Arthritis and Rheumatism | 2000 | 212 |
17 | Validation of a Japanese version of the Stanford Health Assessment Questionnaire in 3,763 patients with rheumatoid arthritis | Arthritis and Rheumatism | 2003 | 206 |
18 | Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients | FEBS Journal | 2008 | 202 |
19 | IL‐17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti‐TNF‐α antibody: A novel mechanism of osteoclastogenesis by IL‐17 | Journal of Cellular Biochemistry | 2009 | 183 |
20 | IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats | Arthritis Research and Therapy | 2007 | 164 |
21 | Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose–response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate to Validate inhibitory effect on bone Erosion (DRIVE)—a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial | Annals of the Rheumatic Diseases | 2016 | 157 |
22 | Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease | Rheumatology | 2014 | 153 |
23 | Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis | PLoS Genetics | 2013 | 146 |
24 | Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis | Rheumatology | 2010 | 143 |
25 | Mortality and cause of death in Japanese patients with rheumatoid arthritis based on a large observational cohort, IORRA | Scandinavian Journal of Rheumatology | 2010 | 138 |
26 | Association betweenPADI4 and rheumatoid arthritis: A replication study | Arthritis and Rheumatism | 2005 | 133 |
27 | Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis | Nature Genetics | 2017 | 130 |
28 | Increased CD40 Expression on Muscle Cells of Polymyositis and Dermatomyositis: Role of CD40-CD40 Ligand Interaction in IL-6, IL-8, IL-15, and Monocyte Chemoattractant Protein-1 Production | Journal of Immunology | 2000 | 127 |
29 | Estimates of the prevalence of and current treatment practices for rheumatoid arthritis in Japan using reimbursement data from health insurance societies and the IORRA cohort (I) | Modern Rheumatology | 2014 | 124 |
30 | A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis | Rheumatology | 2008 | 123 |
31 | Complications and features after joint surgery in rheumatoid arthritis patients treated with tumour necrosis factor- blockers: perioperative interruption of tumour necrosis factor- blockers decreases complications? | Rheumatology | 2010 | 123 |
32 | IFN-γ-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL | European Journal of Immunology | 2005 | 121 |
33 | Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study | Arthritis Research and Therapy | 2016 | 117 |
34 | Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population | Journal of Human Genetics | 2009 | 115 |
35 | A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese | PLoS Genetics | 2012 | 115 |
36 | Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer | International Journal of Cancer | 2002 | 112 |
37 | A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers | Nature Genetics | 2005 | 112 |
38 | Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled phase 3 trial | Annals of the Rheumatic Diseases | 2019 | 105 |
39 | The molecular mechanism of osteoclastogenesis in rheumatoid arthritis | Arthritis Research | 2002 | 104 |
40 | Japan College of Rheumatology guideline for the use of methotrexate in patients with rheumatoid arthritis | Modern Rheumatology | 2019 | 104 |
41 | Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2021 | 103 |
42 | Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population | Rheumatology | 2006 | 102 |
43 | Association between PADI4 and rheumatoid arthritis: a meta-analysis | Rheumatology | 2006 | 102 |
44 | Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study | Annals of the Rheumatic Diseases | 2012 | 102 |
45 | Initial predictors of poor survival in myositis-associated interstitial lung disease: a multicentre cohort of 497 patients | Rheumatology | 2018 | 101 |
46 | Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: Postmarketing surveillance report of 7740 patients | Modern Rheumatology | 2014 | 100 |
47 | ARTHROSCOPIC SYNOVECTOMY OF THE ELBOW IN RHEUMATOID ARTHRITIS | Journal of Bone and Joint Surgery - Series A | 2002 | 91 |
48 | Increased risk of tuberculosis in patients with rheumatoid arthritis in Japan | Annals of the Rheumatic Diseases | 2006 | 90 |
49 | Frequency of Class III and IV Nephritis in Systemic Lupus Erythematosus Without Clinical Renal Involvement: An Analysis of Predictive Measures | Journal of Rheumatology | 2012 | 89 |
50 | Large-Scale Single-Nucleotide Polymorphism (SNP) and Haplotype Analyses, Using Dense SNP Maps, of 199 Drug-Related Genes in 752 Subjects: the Analysis of the Association between Uncommon SNPs within Haplotype Blocks and the Haplotypes Constructed with Haplotype-Tagging SNPs | American Journal of Human Genetics | 2004 | 88 |