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Top Articles

#TitleJournalYearCitations
1Gene Expression Levels and Immunolocalization of Organic Ion Transporters in the Human KidneyJournal of the American Society of Nephrology: JASN2002450
2Cellular and molecular aspects of drug transport in the kidneyKidney International2000404
3Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiportersBiochemical Pharmacology2007369
4Identification and Functional Characterization of a New Human Kidney–Specific H+/Organic Cation Antiporter, Kidney-Specific Multidrug and Toxin Extrusion 2Journal of the American Society of Nephrology: JASN2006348
5cDNA Cloning and Functional Expression of a Novel Rat Kidney Organic Cation Transporter, OCT2Biochemical and Biophysical Research Communications1996335
6Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1Drug Metabolism and Pharmacokinetics2005313
7Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)Journal of Pharmacology and Experimental Therapeutics2006300
8Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1)Journal of Pharmacology and Experimental Therapeutics1992261
9Cerebrospinal fluid concentration of gefitinib and erlotinib in patients with non-small cell lung cancerCancer Chemotherapy and Pharmacology2012257
10Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicityBiochemical Pharmacology2007217
11Immuno-Localization of H+/Peptide Cotransporter in Rat Digestive TractBiochemical and Biophysical Research Communications1996213
12Effect of clarithromycin on renal excretion of digoxin: Interaction with P-glycoprotein*Clinical Pharmacology and Therapeutics1998201
13C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantationPharmacogenetics and Genomics2002186
14Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidneyJournal of Pharmacology and Experimental Therapeutics1995185
15Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the KidneyJournal of Biological Chemistry1996182
16CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantationPharmacogenetics and Genomics2004182
17Creatinine Transport by Basolateral Organic Cation Transporter hOCT2 in the Human KidneyPharmaceutical Research2004180
18Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicityBiochemical Pharmacology2010180
19Renal Transport of Adefovir, Cidofovir, and Tenofovir by SLC22A Family Members (hOAT1, hOAT3, and hOCT2)Pharmaceutical Research2007174
20An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients2006173
21Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy*Clinical Pharmacology and Therapeutics1997170
22Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial CellsJournal of Pharmacology and Experimental Therapeutics2009170
23(Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) Peptide Transporters: Structure, Function, Regulation and Application for Drug DeliveryCurrent Drug Metabolism2004167
24Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugsJournal of Pharmacology and Experimental Therapeutics1998165
25Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of MetforminMolecular Pharmacology2009162
26Metformin Transport by Renal Basolateral Organic Cation Transporter hOCT2Pharmaceutical Research2005156
27Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomicsBritish Journal of Pharmacology2011155
28Carrier-mediated transport systems of tetraethylammonium in rat renal brush-border and basolateral membrane vesiclesBiochimica Et Biophysica Acta - Biomembranes1984152
29Association between tubular toxicity of cisplatin and expression of organic cation transporter rOCT2 (Slc22a2) in the ratBiochemical Pharmacology2005152
30Gender differences in expression of organic cation transporter OCT2 in rat kidneyFEBS Letters1999148
31Organic cation transporter OCT/SLC22A and H+/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agentsBiochemical Pharmacology2011148
32Molecular cloning and tissue distribution of rat peptide transporter PEPT2Biochimica Et Biophysica Acta - Biomembranes1996135
33Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomyKidney International2002132
34Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A)Biochemical Pharmacology2008131
35Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1American Journal of Physiology - Cell Physiology2008126
36Hormonal regulation of organic cation transporter OCT2 expression in rat kidneyFEBS Letters2000125
37Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipientsPharmacogenetics and Genomics2006125
38Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52Molecular Aspects of Medicine2013125
39Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidneyFEBS Letters1998124
40SLCO4C1 Transporter Eliminates Uremic Toxins and Attenuates Hypertension and Renal InflammationJournal of the American Society of Nephrology: JASN2009124
41A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa StudyCirculation Journal2007121
42Identification and Comparative Functional Characterization of a New Human Riboflavin Transporter hRFT3 Expressed in the BrainJournal of Nutrition2010121
43Pharmacokinetic and prognostic significance of intestinal MDR1 expression in recipients of living-donor liver transplantationClinical Pharmacology and Therapeutics2001120
44Molecular Cloning, Functional Characterization and Tissue Distribution of Rat H+/Organic Cation Antiporter MATE1Pharmaceutical Research2006120
45cDNA Cloning, Functional Characterization, and Tissue Distribution of an Alternatively Spliced Variant of Organic Cation Transporter hOCT2 Predominantly Expressed in the Human KidneyJournal of the American Society of Nephrology: JASN2002114
46Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1Biochemical Pharmacology2005114
47Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipientClinical Pharmacology and Therapeutics2000109
48Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acidsThe Histochemical Journal1999103
49Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidneyMolecular Pharmacology1999102
50INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activityBlood2007100