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Top Articles

#TitleJournalYearCitations
1Autophagy in major human diseasesEMBO Journal2021615
2A lipidome atlas in MS-DIAL 4Nature Biotechnology2020424
3Activation of Necroptosis in Multiple SclerosisCell Reports2015413
4Chaperone-mediated autophagy is involved in the execution of ferroptosisProceedings of the National Academy of Sciences of the United States of America2019352
5Amyloid fibril structure of α-synuclein determined by cryo-electron microscopyCell Research2018339
6A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase DegraderCell Chemical Biology2018313
7TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in AgingCell2018291
8Necroptosis in development and diseasesGenes and Development2018270
9Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomicsNature Communications2019218
10Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosisNature Communications2017210
11Ion mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomicsNature Communications2020194
12Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formationNature Structural and Molecular Biology2018185
13PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteinsCell Research2019175
14Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild ConditionsJournal of the American Chemical Society2016170
15One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAsCell Research2017164
16Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseasesScience China Life Sciences2020164
17A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1Nature2020163
18Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assemblyNature Communications2019157
19Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expressionCell Death and Disease2018141
20SWATH enables precise label-free quantification on proteome scaleProteomics2015140
21Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrierProceedings of the National Academy of Sciences of the United States of America2015123
22Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK HyperactivationCell2020123
23Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase SeparationMolecular Cell2020118
24Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylationNature Structural and Molecular Biology2020117
25Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in DrosophilaELife2018113
26Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EMProceedings of the National Academy of Sciences of the United States of America2020113
27An integrated targeted metabolomic platform for high-throughput metabolite profiling and automated data processingMetabolomics2015112
28Cryo-EM structure of an amyloid fibril formed by full-length human prion proteinNature Structural and Molecular Biology2020112
29Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosisProceedings of the National Academy of Sciences of the United States of America2018110
30Structure-Based Design of Functional Amyloid MaterialsJournal of the American Chemical Society2014102
31Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technologyAnalytical and Bioanalytical Chemistry2019102
32SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker DiscoveryAnalytical Chemistry201899
33Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosisProceedings of the National Academy of Sciences of the United States of America201895
34Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical CircuitsNeuron202094
35Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutationCell Research202094
36Versatile Structures of α-SynucleinFrontiers in Molecular Neuroscience201692
37USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1Genes and Development201689
38Double agents: genes with both oncogenic and tumor-suppressor functionsOncogenesis201888
39TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKLMolecular Cell201987
40Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular InteractionsJournal of the American Chemical Society201685
41Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer TreatmentJournal of Medicinal Chemistry201785
42Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome systemELife201584
43Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylationAutophagy201884
44PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIPProceedings of the National Academy of Sciences of the United States of America201783
45ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSCNature Cell Biology201883
46G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14LELife201580
47Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in MiceHepatology202178
48Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteomeProceedings of the National Academy of Sciences of the United States of America201577
49Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferonAutophagy201576
50Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structureNature Communications202076