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Interdisciplinary Research Center on Biology and Chemistry
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top-articles
Interdisciplinary Research Center on Biology and Chemistry
250
(top 1%)
papers
10.3K
(top 1%)
citations
55
(top 1%)
h
-index
94
(top 1%)
g
-index
288
all documents
12.2K
doc citations
1.7K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Autophagy in major human diseases
EMBO Journal
2021
615
2
A lipidome atlas in MS-DIAL 4
Nature Biotechnology
2020
424
3
Activation of Necroptosis in Multiple Sclerosis
Cell Reports
2015
413
4
Chaperone-mediated autophagy is involved in the execution of ferroptosis
Proceedings of the National Academy of Sciences of the United States of America
2019
352
5
Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy
Cell Research
2018
339
6
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Cell Chemical Biology
2018
313
7
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Cell
2018
291
8
Necroptosis in development and diseases
Genes and Development
2018
270
9
Metabolic reaction network-based recursive metabolite annotation for untargeted metabolomics
Nature Communications
2019
218
10
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
Nature Communications
2017
210
11
Ion mobility collision cross-section atlas for known and unknown metabolite annotation in untargeted metabolomics
Nature Communications
2020
194
12
Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation
Nature Structural and Molecular Biology
2018
185
13
PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
Cell Research
2019
175
14
Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions
Journal of the American Chemical Society
2016
170
15
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs
Cell Research
2017
164
16
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Science China Life Sciences
2020
164
17
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
Nature
2020
163
18
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly
Nature Communications
2019
157
19
Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression
Cell Death and Disease
2018
141
20
SWATH enables precise label-free quantification on proteome scale
Proteomics
2015
140
21
Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier
Proceedings of the National Academy of Sciences of the United States of America
2015
123
22
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Cell
2020
123
23
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
Molecular Cell
2020
118
24
Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation
Nature Structural and Molecular Biology
2020
117
25
Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila
ELife
2018
113
26
Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM
Proceedings of the National Academy of Sciences of the United States of America
2020
113
27
An integrated targeted metabolomic platform for high-throughput metabolite profiling and automated data processing
Metabolomics
2015
112
28
Cryo-EM structure of an amyloid fibril formed by full-length human prion protein
Nature Structural and Molecular Biology
2020
112
29
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Proceedings of the National Academy of Sciences of the United States of America
2018
110
30
Structure-Based Design of Functional Amyloid Materials
Journal of the American Chemical Society
2014
102
31
Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology
Analytical and Bioanalytical Chemistry
2019
102
32
SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker Discovery
Analytical Chemistry
2018
99
33
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis
Proceedings of the National Academy of Sciences of the United States of America
2018
95
34
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits
Neuron
2020
94
35
Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation
Cell Research
2020
94
36
Versatile Structures of α-Synuclein
Frontiers in Molecular Neuroscience
2016
92
37
USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1
Genes and Development
2016
89
38
Double agents: genes with both oncogenic and tumor-suppressor functions
Oncogenesis
2018
88
39
TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL
Molecular Cell
2019
87
40
Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions
Journal of the American Chemical Society
2016
85
41
Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment
Journal of Medicinal Chemistry
2017
85
42
Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system
ELife
2015
84
43
Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
Autophagy
2018
84
44
PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP
Proceedings of the National Academy of Sciences of the United States of America
2017
83
45
ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC
Nature Cell Biology
2018
83
46
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
ELife
2015
80
47
Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice
Hepatology
2021
78
48
Fmr1
deficiency promotes age-dependent alterations in the cortical synaptic proteome
Proceedings of the National Academy of Sciences of the United States of America
2015
77
49
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
Autophagy
2015
76
50
Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure
Nature Communications
2020
76
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