| # | Title | Journal | Year | Citations |
|---|
| 1 | Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration | Pharmacology Biochemistry and Behavior | 1979 | 426 |
| 2 | Endothelin-1 Increases Vascular Superoxide via Endothelin A –NADPH Oxidase Pathway in Low-Renin Hypertension | Circulation | 2003 | 309 |
| 3 | Cannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System | Toxicology and Applied Pharmacology | 1997 | 306 |
| 4 | Serotonin and Blood Pressure Regulation | Pharmacological Reviews | 2012 | 306 |
| 5 | The effects of hypertension on the cerebral circulation | American Journal of Physiology - Heart and Circulatory Physiology | 2013 | 303 |
| 6 | Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors | Nature Medicine | 2012 | 286 |
| 7 | The multifaceted role of fibrinogen in tissue injury and inflammation | Blood | 2019 | 279 |
| 8 | Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature | Pharmacological Reviews | 2000 | 277 |
| 9 | Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System | | 2016 | 275 |
| 10 | Mechanisms of methylmercury‐induced neurotoxicity | FASEB Journal | 1994 | 262 |
| 11 | The Vascular System as a Target of Metal Toxicity | Toxicological Sciences | 2008 | 254 |
| 12 | Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles | | 2017 | 250 |
| 13 | Systematic review: cardiovascular safety profile of 5‐HT4 agonists developed for gastrointestinal disorders | Alimentary Pharmacology and Therapeutics | 2012 | 236 |
| 14 | Alterations in DNA methylation may play a variety of roles in carcinogenesis | Cell | 1995 | 226 |
| 15 | Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity | Gastroenterology | 2012 | 224 |
| 16 | Safety assessment of allylalkoxybenzene derivatives used as flavouring substances — methyl eugenol and estragole | Food and Chemical Toxicology | 2002 | 221 |
| 17 | Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of Plasminogen Activator Inhibitor-1 | Gastroenterology | 2006 | 192 |
| 18 | A Comparison of Biochemical Indices of 5‐Hydroxytryptaminergic Neuronal Activity Following Electrical Stimulation of the Dorsal Raphe Nucleus | Journal of Neurochemistry | 1986 | 190 |
| 19 | Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies | NeuroToxicology | 1991 | 190 |
| 20 | M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia | Neuron | 2015 | 183 |
| 21 | Mechanisms of Inflammatory Liver Injury: Adhesion Molecules and Cytotoxicity of Neutrophils | Toxicology and Applied Pharmacology | 1996 | 179 |
| 22 | Neutrophil migration during endotoxemia | Journal of Leukocyte Biology | 1999 | 177 |
| 23 | Molecular Neurobiology of Lead (Pb2+): Effects on Synaptic Function | Molecular Neurobiology | 2010 | 173 |
| 24 | ATP mediates fast synaptic potentials in enteric neurons | Journal of Neuroscience | 1994 | 172 |
| 25 | Ca2+ Responses in Enteric Glia Are Mediated by Connexin-43 Hemichannels and Modulate Colonic Transit in Mice | Gastroenterology | 2014 | 168 |
| 26 | Interactions between Prolactin and Dopaminergic Neurons1 | Biology of Reproduction | 1987 | 165 |
| 27 | Particulate matter, oxidative stress and neurotoxicity | NeuroToxicology | 2008 | 164 |
| 28 | Photoimmunology: how ultraviolet radiation affects the immune system | Nature Reviews Immunology | 2019 | 162 |
| 29 | Dietary fish oil inhibits human breast carcinoma growth: A function of increased lipid peroxidation | Lipids | 1993 | 159 |
| 30 | Is Exposure to Bacterial Endotoxin a Determinant of Susceptibility to Intoxication from Xenobiotic Agents? | Toxicology and Applied Pharmacology | 1997 | 155 |
| 31 | Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2 | Molecular Pharmacology | 2006 | 153 |
| 32 | Accumulation of L-Dopa in the Median Eminence: An Index of Tuberoinfundibular Dopaminergic Nerve Activity* | Endocrinology | 1980 | 152 |
| 33 | Comparison of dopamine synthesis regulation in the terminals of nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal neurons | Journal of Neural Transmission | 1979 | 144 |
| 34 | 5-HYDROXYTRYPTAMINE IN THE CARDIOVASCULAR SYSTEM: FOCUS ON THE SEROTONIN TRANSPORTER (SERT) | Clinical and Experimental Pharmacology and Physiology | 2006 | 144 |
| 35 | Ranitidine Treatment during a Modest Inflammatory Response Precipitates Idiosyncrasy-Like Liver Injury in Rats | Journal of Pharmacology and Experimental Therapeutics | 2003 | 138 |
| 36 | Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis | American Journal of Pathology | 2015 | 138 |
| 37 | Human Adenovirus 36 Induces Adiposity, Increases Insulin Sensitivity, and Alters Hypothalamic Monoamines in Rats | Obesity | 2006 | 137 |
| 38 | Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha | Toxicological Sciences | 2007 | 136 |
| 39 | Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function | Hypertension | 2014 | 134 |
| 40 | A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils | Food and Chemical Toxicology | 2005 | 133 |
| 41 | Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice | Hepatology | 2007 | 132 |
| 42 | Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity—Two Villains or One? | Journal of Pharmacology and Experimental Therapeutics | 2010 | 131 |
| 43 | Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation | Journal of Immunology | 2004 | 129 |
| 44 | Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor | Chemico-Biological Interactions | 2004 | 128 |
| 45 | Splanchnic Circulation Is a Critical Neural Target in Angiotensin II Salt Hypertension in Rats | Hypertension | 2007 | 126 |
| 46 | Chemerin Connects Fat to Arterial Contraction | Arteriosclerosis, Thrombosis, and Vascular Biology | 2013 | 126 |
| 47 | An intrinsic potential‐dependent inactivation mechanism associated with calcium channels in guinea‐pig myocytes. | Journal of Physiology | 1987 | 125 |
| 48 | Evidence That Hypothalamic Periventricular Dopamine Neurons Innervate the Intermediate Lobe of the Rat Pituitary | Neuroendocrinology | 1992 | 125 |
| 49 | Inflammation and Drug Idiosyncrasy—Is There a Connection? | Journal of Pharmacology and Experimental Therapeutics | 2003 | 124 |
| 50 | Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment | European Journal of Medicinal Chemistry | 2017 | 124 |
