| # | Title | Journal | Year | Citations |
|---|
| 1 | Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection | Cell | 1993 | 1,640 |
| 2 | Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines | Science | 1983 | 959 |
| 3 | Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies | Nature | 1985 | 899 |
| 4 | Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines | Nature | 1985 | 801 |
| 5 | Exploring the role of cancer stem cells in radioresistance | Nature Reviews Cancer | 2008 | 766 |
| 6 | Suppression of tumor growth and metastasis in Mgat5-deficient mice | Nature Medicine | 2000 | 511 |
| 7 | The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein | Biochemical and Biophysical Research Communications | 1986 | 389 |
| 8 | Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice | Science | 1992 | 340 |
| 9 | Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat | Cell | 2015 | 308 |
| 10 | Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage | International Journal of Hyperthermia | 2003 | 297 |
| 11 | Patient dose from kilovoltage cone beam computed tomography imaging in radiation therapy | Medical Physics | 2006 | 275 |
| 12 | p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle Arrest | Molecular and Cellular Biology | 2005 | 265 |
| 13 | CD45: new jobs for an old acquaintance | Nature Immunology | 2001 | 264 |
| 14 | Mechanism of multidrug resistance | Biochimica Et Biophysica Acta: Reviews on Cancer | 1988 | 258 |
| 15 | Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid–induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters | Journal of Neurosurgery | 2011 | 250 |
| 16 | Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven | Cancer Research | 2006 | 244 |
| 17 | Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer | Cancer Research | 2011 | 241 |
| 18 | Targeting tumor cell metabolism with statins | Oncogene | 2012 | 193 |
| 19 | The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila | Oncogene | 2000 | 185 |
| 20 | Transcriptional repression mediated by the p53 tumour suppressor | Cell Death and Differentiation | 2003 | 179 |
| 21 | Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance | Cell Metabolism | 2011 | 162 |
| 22 | pVHL Modification by NEDD8 Is Required for Fibronectin Matrix Assembly and Suppression of Tumor Development | Molecular and Cellular Biology | 2004 | 156 |
| 23 | Nonlinear Optical Properties of Type I Collagen Fibers Studied by Polarization Dependent Second Harmonic Generation Microscopy | Journal of Physical Chemistry B | 2011 | 131 |
| 24 | Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1 | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 120 |
| 25 | Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity | Molecular Cancer Therapeutics | 2009 | 95 |
| 26 | A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities | Molecular Systems Biology | 2013 | 90 |
| 27 | Compensators for dose and scatter management in cone‐beam computed tomography | Medical Physics | 2007 | 88 |
| 28 | Network-based characterization of drug-regulated genes, drug targets, and toxicity | Methods | 2012 | 88 |
| 29 | Potentiation of Chlorin e6 Photodynamic Activity in Vitro with Peptide-Based Intracellular Vehicles | Bioconjugate Chemistry | 1999 | 87 |
| 30 | Phosphoinositide-Dependent Phosphorylation of PDK1 Regulates Nuclear Translocation | Molecular and Cellular Biology | 2005 | 81 |
| 31 | Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein | Journal of Cellular Physiology | 1991 | 76 |
| 32 | Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function | Blood | 2013 | 74 |
| 33 | Sex-dependent and independent expression of the P-glycoprotein isoforms in Chinese hamster | Journal of Cellular Physiology | 1990 | 73 |
| 34 | Role of nuclear protein denaturation and aggregation in thermal radiosensitization | International Journal of Hyperthermia | 2004 | 71 |
| 35 | Comparative genomic hybridization analysis identifies gains of 1p35∼p36 and chromosome 19 in osteosarcoma | Cancer Genetics and Cytogenetics | 2001 | 69 |
| 36 | Specificity of Processing α-Glucosidase I Is Guided by the Substrate Conformation | Journal of Biological Chemistry | 2013 | 65 |
| 37 | Partial volume rat lung irradiation: The protective/mitigating effects of Eukarion-189, a superoxide dismutase–catalase mimetic | Radiotherapy and Oncology | 2006 | 61 |
| 38 | Hybrid Quantum Dot−Fatty Ester Stealth Nanoparticles: Toward Clinically Relevant in Vivo Optical Imaging of Deep Tissue | ACS Nano | 2011 | 56 |
| 39 | The Evolution of an Intron: Analysis of a Long, Deletion-Prone Intron in the Human Dystrophin Gene | Genomics | 1997 | 55 |
| 40 | Genetic Polymorphisms and Head and Neck Cancer Outcomes: A Review | Cancer Epidemiology Biomarkers and Prevention | 2008 | 55 |
| 41 | Tumor Suppression by the von Hippel-Lindau Protein Requires Phosphorylation of the Acidic Domain | Journal of Biological Chemistry | 2005 | 51 |
| 42 | Altered plasma membrane ultrastructure in multidrug-resistant cells | Biochimica Et Biophysica Acta - Biomembranes | 1988 | 49 |
| 43 | Peptide-Based Intracellular Shuttle Able To Facilitate Gene Transfer in Mammalian Cells | Bioconjugate Chemistry | 1999 | 49 |
| 44 | Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II α-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms, | Biochemistry | 2003 | 48 |
| 45 | Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum–early endosome interface | Journal of Cell Science | 2011 | 48 |
| 46 | Suppression of Cancer Progression by MGAT1 shRNA Knockdown | PLoS ONE | 2012 | 47 |
| 47 | Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer | Oncogene | 2017 | 47 |
| 48 | Evaluation of the effect of patient dose from cone beam computed tomography on prostate IMRT using Monte Carlo simulation | Medical Physics | 2008 | 45 |
| 49 | A new approach to CT pixel-based photon dose calculations in heterogeneous media | Medical Physics | 1983 | 44 |
| 50 | Penetration and Intracellular Routing of Nucleus-Directed Peptide-Based Shuttles (Loligomers) in Eukaryotic Cells† | Biochemistry | 1998 | 43 |
