| # | Title | Journal | Year | Citations |
|---|
| 1 | p53, the Cellular Gatekeeper for Growth and Division | Cell | 1997 | 7,028 |
| 2 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus | Cell | 2003 | 5,290 |
| 3 | Quorum Sensing in Bacteria | Annual Review of Microbiology | 2001 | 4,088 |
| 4 | Predicting coiled coils from protein sequences | Science | 1991 | 3,896 |
| 5 | The p53 tumour suppressor gene | Nature | 1991 | 3,755 |
| 6 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,688 |
| 7 | Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 3,486 |
| 8 | QUORUM SENSING: Cell-to-Cell Communication in Bacteria | Annual Review of Cell and Developmental Biology | 2005 | 3,198 |
| 9 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 10 | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET | Nature Medicine | 2012 | 3,098 |
| 11 | The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Cell | 1992 | 2,890 |
| 12 | The Bacterial Cell Envelope | Cold Spring Harbor Perspectives in Biology | 2010 | 2,408 |
| 13 | Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain | Science | 1996 | 2,053 |
| 14 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate | Cancer Cell | 2010 | 1,754 |
| 15 | Genetic enhancement of learning and memory in mice | Nature | 1999 | 1,666 |
| 16 | Molecular mechanisms of caspase regulation during apoptosis | Nature Reviews Molecular Cell Biology | 2004 | 1,651 |
| 17 | The p53-mdm-2 autoregulatory feedback loop. | Genes and Development | 1993 | 1,552 |
| 18 | Mechanisms of Caspase Activation and Inhibition during Apoptosis | Molecular Cell | 2002 | 1,520 |
| 19 | Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control | Cold Spring Harbor Perspectives in Medicine | 2012 | 1,460 |
| 20 | Bacterial Quorum-Sensing Network Architectures | Annual Review of Genetics | 2009 | 1,426 |
| 21 | The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2 | Journal of Biological Chemistry | 2008 | 1,414 |
| 22 | Stem Cells and Their Niches | Science | 2006 | 1,403 |
| 23 | A Stem Cell Molecular Signature | Science | 2002 | 1,398 |
| 24 | CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus | Nature | 2000 | 1,386 |
| 25 | Structural identification of a bacterial quorum-sensing signal containing boron | Nature | 2002 | 1,379 |
| 26 | Continuous Particle Separation Through Deterministic Lateral Displacement | Science | 2004 | 1,367 |
| 27 | The CRAPome: a contaminant repository for affinity purification–mass spectrometry data | Nature Methods | 2013 | 1,353 |
| 28 | Real-Time Kinetics of Gene Activity in Individual Bacteria | Cell | 2005 | 1,334 |
| 29 | Stretching DNA with optical tweezers | Biophysical Journal | 1997 | 1,315 |
| 30 | Pre-metastatic niches: organ-specific homes for metastases | Nature Reviews Cancer | 2017 | 1,272 |
| 31 | MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function | Annual Review of Immunology | 1997 | 1,259 |
| 32 | In yeast, RAS proteins are controlling elements of adenylate cyclase | Cell | 1985 | 1,209 |
| 33 | A synthetic multicellular system for programmed pattern formation | Nature | 2005 | 1,197 |
| 34 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 35 | The genome of the social amoeba Dictyostelium discoideum | Nature | 2005 | 1,179 |
| 36 | DNA secondary structures: stability and function of G-quadruplex structures | Nature Reviews Genetics | 2012 | 1,162 |
| 37 | Parental imprinting of the mouse H19 gene | Nature | 1991 | 1,151 |
| 38 | Summing up the noise in gene networks | Nature | 2004 | 1,143 |
| 39 | Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. | Molecular and Cellular Biology | 1988 | 1,105 |
| 40 | Pulsed contractions of an actin–myosin network drive apical constriction | Nature | 2009 | 1,089 |
| 41 | Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions | Cell | 2010 | 1,069 |
| 42 | Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein | Cell | 1991 | 1,055 |
| 43 | A genomic storm in critically injured humans | Journal of Experimental Medicine | 2011 | 1,040 |
| 44 | Robustness in bacterial chemotaxis | Nature | 1999 | 1,035 |
| 45 | A chemical switch for inhibitor-sensitive alleles of any protein kinase | Nature | 2000 | 1,001 |
| 46 | Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice | Neuron | 2007 | 993 |
| 47 | Crystal Structure of the PTEN Tumor Suppressor | Cell | 1999 | 974 |
| 48 | Bacterially Speaking | Cell | 2006 | 963 |
| 49 | Single kinesin molecules studied with a molecular force clamp | Nature | 1999 | 946 |
| 50 | A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | Nature | 2001 | 933 |
