| # | Title | Journal | Year | Citations |
|---|
| 1 | Hallmarks of Cancer: The Next Generation | Cell | 2011 | 52,242 |
| 2 | A Rapid Bootstrap Algorithm for the RAxML Web Servers | Systematic Biology | 2008 | 6,439 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment | Cancer Cell | 2012 | 3,578 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | The many faces of α-synuclein: from structure and toxicity to therapeutic target | Nature Reviews Neuroscience | 2013 | 1,322 |
| 7 | The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling | Cell | 2013 | 951 |
| 8 | Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study | Lancet, The | 2020 | 919 |
| 9 | Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17 | Journal of Chemical Information and Modeling | 2012 | 871 |
| 10 | Multisensory brain mechanisms of bodily self-consciousness | Nature Reviews Neuroscience | 2012 | 858 |
| 11 | Genomics and the origin of species | Nature Reviews Genetics | 2014 | 850 |
| 12 | Statistical physics of vaccination | Physics Reports | 2016 | 734 |
| 13 | KAP1 controls endogenous retroviruses in embryonic stem cells | Nature | 2010 | 677 |
| 14 | Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents | Nature Medicine | 2016 | 668 |
| 15 | A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer | Nature Medicine | 2009 | 566 |
| 16 | Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance | Nature Medicine | 2015 | 562 |
| 17 | Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling | Plant Journal | 2012 | 498 |
| 18 | Nanomaterials for Drug Delivery | Science | 2012 | 465 |
| 19 | Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila | Cell Reports | 2013 | 421 |
| 20 | A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation | Cell | 2014 | 414 |
| 21 | Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing | Science | 2014 | 406 |
| 22 | N-glycan structures: recognition and processing in the ER | Trends in Biochemical Sciences | 2010 | 404 |
| 23 | Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 401 |
| 24 | Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver | PLoS Biology | 2011 | 395 |
| 25 | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Science Immunology | 2021 | 357 |
| 26 | Influence of HLA-C Expression Level on HIV Control | Science | 2013 | 352 |
| 27 | Regulation of innate and adaptive immunity by Notch | Nature Reviews Immunology | 2013 | 343 |
| 28 | Glucose transporters in cancer – from tumor cells to the tumor microenvironment | FEBS Journal | 2018 | 341 |
| 29 | Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2 | PLoS ONE | 2011 | 338 |
| 30 | The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer | Science | 2015 | 337 |
| 31 | Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication | Cell Host and Microbe | 2010 | 332 |
| 32 | CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors | Nature Immunology | 2020 | 326 |
| 33 | Structural Basis of the 9-Fold Symmetry of Centrioles | Cell | 2011 | 317 |
| 34 | Conservation of transcription factor binding specificities across 600 million years of bilateria evolution | ELife | 2015 | 316 |
| 35 | Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster | Genetics | 2018 | 304 |
| 36 | Notch as a tumour suppressor | Nature Reviews Cancer | 2017 | 301 |
| 37 | Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice | Hepatology | 2016 | 289 |
| 38 | Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells | Nature Communications | 2015 | 274 |
| 39 | Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils | Science | 2017 | 270 |
| 40 | The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice | Gastroenterology | 2013 | 265 |
| 41 | Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 263 |
| 42 | Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis | Nature Cell Biology | 2019 | 254 |
| 43 | Molecular architecture of the developing mouse brain | Nature | 2021 | 254 |
| 44 | Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors | Endocrinology | 2015 | 253 |
| 45 | The Circadian Clock Coordinates Ribosome Biogenesis | PLoS Biology | 2013 | 243 |
| 46 | Guidelines for Genome-Scale Analysis of Biological Rhythms | Journal of Biological Rhythms | 2017 | 237 |
| 47 | Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares | Science | 2018 | 234 |
| 48 | Artificial three-dimensional niches deconstruct pancreas developmentin vitro | Development (Cambridge) | 2013 | 233 |
| 49 | Defined three-dimensional microenvironments boost induction of pluripotency | Nature Materials | 2016 | 233 |
| 50 | High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays | Nature Biomedical Engineering | 2020 | 231 |
