| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Succinate is an inflammatory signal that induces IL-1β through HIF-1α | Nature | 2013 | 2,845 |
| 3 | The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling | Nature Reviews Immunology | 2007 | 2,285 |
| 4 | A guide to immunometabolism for immunologists | Nature Reviews Immunology | 2016 | 2,100 |
| 5 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases | Nature Medicine | 2015 | 1,967 |
| 6 | Trained immunity: A program of innate immune memory in health and disease | Science | 2016 | 1,809 |
| 7 | mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity | Science | 2014 | 1,517 |
| 8 | Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages | Cell | 2016 | 1,396 |
| 9 | IFI16 is an innate immune sensor for intracellular DNA | Nature Immunology | 2010 | 1,369 |
| 10 | The history of Toll-like receptors — redefining innate immunity | Nature Reviews Immunology | 2013 | 1,338 |
| 11 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity | Cell Research | 2015 | 1,265 |
| 12 | Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 | Nature | 2018 | 1,115 |
| 13 | Resolution of in flammation: state of the art, definitions and terms | FASEB Journal | 2007 | 949 |
| 14 | Metabolism of inflammation limited by AMPK and pseudo-starvation | Nature | 2013 | 946 |
| 15 | A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes | Science | 2013 | 925 |
| 16 | Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages | Cell Metabolism | 2015 | 887 |
| 17 | MicroRNAs: the fine-tuners of Toll-like receptor signalling | Nature Reviews Immunology | 2011 | 800 |
| 18 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 19 | Macrophage Immunometabolism: Where Are We (Going)? | Trends in Immunology | 2017 | 758 |
| 20 | Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation | Journal of Biological Chemistry | 2011 | 723 |
| 21 | Targeting Toll-like receptors: emerging therapeutics? | Nature Reviews Drug Discovery | 2010 | 721 |
| 22 | Mitochondria are the powerhouses of immunity | Nature Immunology | 2017 | 704 |
| 23 | Liver immunology and its role in inflammation and homeostasis | Cellular and Molecular Immunology | 2016 | 693 |
| 24 | Immune Sensing of DNA | Immunity | 2013 | 672 |
| 25 | Metabolic Reprograming in Macrophage Polarization | Frontiers in Immunology | 2014 | 649 |
| 26 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection | PLoS ONE | 2020 | 634 |
| 27 | Viral evasion and subversion of pattern-recognition receptor signalling | Nature Reviews Immunology | 2008 | 616 |
| 28 | How Toll-like receptors signal: what we know and what we don’t know | Current Opinion in Immunology | 2006 | 572 |
| 29 | The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress | Immunological Reviews | 2008 | 565 |
| 30 | Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity | Biochemical Pharmacology | 2006 | 549 |
| 31 | PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells | Journal of Experimental Medicine | 2012 | 518 |
| 32 | Succinate: a metabolic signal in inflammation | Trends in Cell Biology | 2014 | 507 |
| 33 | Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project | Nature Biotechnology | 2008 | 506 |
| 34 | A guiding map for inflammation | Nature Immunology | 2017 | 506 |
| 35 | Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor | Immunity | 2012 | 456 |
| 36 | Circadian Clock Proteins and Immunity | Immunity | 2014 | 451 |
| 37 | CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis | Journal of Immunology | 2009 | 430 |
| 38 | The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons | Immunity | 2016 | 429 |
| 39 | Immune checkpoints and their inhibition in cancer and infectious diseases | European Journal of Immunology | 2017 | 418 |
| 40 | Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage | Molecular Cell | 2018 | 417 |
| 41 | A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis | Nature Genetics | 2007 | 411 |
| 42 | A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation? | Nature Immunology | 2012 | 402 |
| 43 | T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells | Science | 2016 | 395 |
| 44 | The Warburg effect then and now: From cancer to inflammatory diseases | BioEssays | 2013 | 391 |
| 45 | Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer | Pharmacological Reviews | 2009 | 387 |
| 46 | Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production | Journal of Immunology | 2012 | 387 |
| 47 | BCG-induced trained immunity: can it offer protection against COVID-19? | Nature Reviews Immunology | 2020 | 384 |
| 48 | NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components | Nature Medicine | 2012 | 365 |
| 49 | A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation | Frontiers in Immunology | 2018 | 363 |
| 50 | miR‐223: infection, inflammation and cancer | Journal of Internal Medicine | 2013 | 360 |
