| # | Title | Journal | Year | Citations |
|---|
| 1 | Peutz-Jeghers syndrome: a systematic review and recommendations for management | Gut | 2010 | 635 |
| 2 | Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts | Gut | 2013 | 630 |
| 3 | Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study | Lancet, The | 2000 | 615 |
| 4 | Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer | American Journal of Human Genetics | 2004 | 597 |
| 5 | Guidelines for the clinical management of familial adenomatous polyposis (FAP) | Gut | 2008 | 591 |
| 6 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers | Clinical Chemistry | 2008 | 539 |
| 7 | The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome | International Journal of Cancer | 2008 | 481 |
| 8 | Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer) | Journal of Medical Genetics | 2007 | 461 |
| 9 | Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use | European Journal of Cancer | 2007 | 437 |
| 10 | Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database | Gut | 2017 | 411 |
| 11 | CTCF/cohesin-binding sites are frequently mutated in cancer | Nature Genetics | 2015 | 383 |
| 12 | Vascular Endothelial Growth Factor Receptor-3 in Lymphangiogenesis in Wound Healing | American Journal of Pathology | 2000 | 352 |
| 13 | Clinical utility of biochemical markers in colorectal cancer | European Journal of Cancer | 2003 | 336 |
| 14 | Health-related quality of life of multiple organ dysfunction patients one year after intensive care | Intensive Care Medicine | 2000 | 321 |
| 15 | Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics | PLoS Genetics | 2008 | 315 |
| 16 | Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study | Critical Care | 2012 | 308 |
| 17 | Tumor markers in pancreatic cancer: a European Group on Tumor Markers (EGTM) status report | Annals of Oncology | 2010 | 300 |
| 18 | SuPAR and PAI-1 in critically ill, mechanically ventilated patients | Intensive Care Medicine | 2013 | 296 |
| 19 | Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update | International Journal of Cancer | 2014 | 288 |
| 20 | Celiac disease in patients with severe liver disease: Gluten-free diet may reverse hepatic failure | Gastroenterology | 2002 | 266 |
| 21 | Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry | Gut | 2005 | 266 |
| 22 | Determinants of Procedural Pain Intensity in the Intensive Care Unit. The Europain® Study | American Journal of Respiratory and Critical Care Medicine | 2014 | 259 |
| 23 | Effect of Lactobacillus rhamnosus GG on ileal pouch inflammation and microbial flora | Alimentary Pharmacology and Therapeutics | 2003 | 248 |
| 24 | Female fecundity before and after operation for familial adenomatous polyposis | British Journal of Surgery | 2003 | 246 |
| 25 | Safety and efficacy of a single bolus administration of recombinant factor VIIa in liver transplantation due to chronic liver disease | Liver Transplantation | 2005 | 224 |
| 26 | Causes of Late Deaths After Pediatric Cardiac Surgery | Journal of the American College of Cardiology | 2007 | 220 |
| 27 | Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk | Nature Genetics | 2012 | 210 |
| 28 | Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation | Intensive Care Medicine | 2009 | 208 |
| 29 | Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study | Intensive Care Medicine | 2007 | 202 |
| 30 | NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer | Nature Genetics | 2008 | 181 |
| 31 | Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis | Intensive Care Medicine | 2002 | 179 |
| 32 | Association analyses identify 31 new risk loci for colorectal cancer susceptibility | Nature Communications | 2019 | 172 |
| 33 | Cell-Free Plasma DNA as a Predictor of Outcome in Severe Sepsis and Septic Shock | Clinical Chemistry | 2008 | 168 |
| 34 | Laminin α1-Chain Shows a Restricted Distribution in Epithelial Basement Membranes of Fetal and Adult Human Tissues | Experimental Cell Research | 2000 | 165 |
| 35 | Survival and quality of life of patients requiring acute renal replacement therapy | Intensive Care Medicine | 2005 | 164 |
| 36 | Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome | International Journal of Cancer | 2007 | 164 |
| 37 | Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents | Inflammatory Bowel Diseases | 2012 | 158 |
| 38 | Treatment-Related Factors Predisposing to Chronic Pain in Patients with Breast CancerA Multivariate Approach | Acta Oncológica | 1997 | 157 |
| 39 | Guidelines in the management of obstructing cancer of the left colon: consensus conference of the world society of emergency surgery (WSES) and peritoneum and surgery (PnS) society | World Journal of Emergency Surgery | 2010 | 157 |
| 40 | CEA, CA 19-9 and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers | Anticancer Research | 2002 | 154 |
| 41 | Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR | Clinical Cancer Research | 2005 | 147 |
| 42 | Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome | Intensive Care Medicine | 2011 | 147 |
| 43 | Predictive value of N-terminal pro–brain natriuretic peptide in severe sepsis and septic shock* | Critical Care Medicine | 2007 | 145 |
| 44 | Laparoscopic surgery for chronic groin pain in athletes is more effective than nonoperative treatment: A randomized clinical trial with magnetic resonance imaging of 60 patients with sportsman’s hernia (athletic pubalgia) | Surgery | 2011 | 144 |
| 45 | The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans | Journal of Hepatology | 2016 | 140 |
| 46 | Inhibition of serum phospholipase-A2in acute pancreatitis by pharmacological agentsin vitro | Scandinavian Journal of Clinical and Laboratory Investigation | 1997 | 138 |
| 47 | Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy | British Journal of Cancer | 2011 | 134 |
| 48 | Cumulative Failure Rate of Ileal Pouch-Anal Anastomosis and Quality of Life After Failure | Diseases of the Colon and Rectum | 2002 | 133 |
| 49 | Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis | Apmis | 2003 | 133 |
| 50 | Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study | Intensive Care Medicine | 2013 | 133 |
