| # | Title | Journal | Year | Citations |
|---|
| 1 | Microbial translocation is a cause of systemic immune activation in chronic HIV infection | Nature Medicine | 2006 | 3,107 |
| 2 | Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome | Molecular Cell | 1998 | 1,654 |
| 3 | Adolescence and the social determinants of health | Lancet, The | 2012 | 1,524 |
| 4 | Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations | Pediatrics | 2008 | 1,106 |
| 5 | Suicide and Suicide Risk in Lesbian, Gay, Bisexual, and Transgender Populations: Review and Recommendations | Journal of Homosexuality | 2010 | 914 |
| 6 | IMMUNOLOGICAL RECONSTITUTION OF SEX-LINKED LYMPHOPENIC IMMUNOLOGICAL DEFICIENCY | Lancet, The | 1968 | 882 |
| 7 | Guidelines for overweight in adolescent preventive services: recommendations from an expert committee | American Journal of Clinical Nutrition | 1994 | 869 |
| 8 | Breast Cancer and Other Second Neoplasms after Childhood Hodgkin's Disease | New England Journal of Medicine | 1996 | 865 |
| 9 | Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy | New England Journal of Medicine | 2017 | 822 |
| 10 | Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent | Science | 2017 | 753 |
| 11 | Cockayne syndrome: Review of 140 cases | American Journal of Medical Genetics Part A | 1992 | 749 |
| 12 | The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r | Nature Cell Biology | 2012 | 747 |
| 13 | Advances in graft-versus-host disease biology and therapy | Nature Reviews Immunology | 2012 | 746 |
| 14 | Insulin resistance during puberty: results from clamp studies in 357 children | Diabetes | 1999 | 737 |
| 15 | Renal and Retinal Effects of Enalapril and Losartan in Type 1 Diabetes | New England Journal of Medicine | 2009 | 712 |
| 16 | Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity | Cell Stem Cell | 2018 | 634 |
| 17 | Study design and cohort characteristics of the childhood cancer survivor study: A multi-institutional collaborative project | Medical and Pediatric Oncology | 2002 | 632 |
| 18 | Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis | Nature Genetics | 2000 | 629 |
| 19 | Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease | Lancet, The | 1995 | 592 |
| 20 | Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH) | Bone Marrow Transplantation | 2002 | 587 |
| 21 | 20 years or more of follow-up of living kidney donors | Lancet, The | 1992 | 572 |
| 22 | Global perspectives on the sexual and reproductive health of adolescents: patterns, prevention, and potential | Lancet, The | 2007 | 553 |
| 23 | Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation | Journal of Experimental Medicine | 2012 | 552 |
| 24 | Trends in childhood cancer incidence in the U.S. (1992–2004) | Cancer | 2008 | 548 |
| 25 | Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade | Nature Medicine | 2019 | 539 |
| 26 | Brain charts for the human lifespan | Nature | 2022 | 518 |
| 27 | Cystic Fibrosis–Related Diabetes: Current Trends in Prevalence, Incidence, and Mortality | Diabetes Care | 2009 | 510 |
| 28 | Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease | Immunity | 2012 | 509 |
| 29 | Adolescent Violence Perpetration: Associations With Multiple Types of Adverse Childhood Experiences | Pediatrics | 2010 | 506 |
| 30 | βCatenin Signaling Activity Dissected in the Early Xenopus Embryo: A Novel Antisense Approach | Developmental Biology | 2000 | 498 |
| 31 | Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type | Cancer | 1995 | 496 |
| 32 | ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency | Science | 1994 | 483 |
| 33 | Osteopetrosis | New England Journal of Medicine | 2004 | 477 |
| 34 | The relationship between suicide risk and sexual orientation: results of a population-based study. | American Journal of Public Health | 1998 | 476 |
| 35 | Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets | New England Journal of Medicine | 2017 | 469 |
| 36 | Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey | Leukemia | 2015 | 455 |
| 37 | Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation | Annual Review of Immunology | 2007 | 454 |
| 38 | Clinical Practice Guideline for Emergency Department Ketamine Dissociative Sedation: 2011 Update | Annals of Emergency Medicine | 2011 | 449 |
| 39 | Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism | Cell | 2018 | 445 |
| 40 | IMMUNOPATHOLOGY OF HYPERACUTE XENOGRAFT REJECTION IN A SWINE-TO-PRIMATE MODEL | Transplantation | 1991 | 418 |
| 41 | Human ES- and iPS-Derived Myogenic Progenitors Restore DYSTROPHIN and Improve Contractility upon Transplantation in Dystrophic Mice | Cell Stem Cell | 2012 | 411 |
| 42 | Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 409 |
| 43 | Suicidality among Gay, Lesbian and Bisexual Youth: The Role of Protective Factors | Journal of Adolescent Health | 2006 | 409 |
| 44 | Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease | Science Translational Medicine | 2013 | 401 |
| 45 | Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene | PLoS Genetics | 2010 | 394 |
| 46 | Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia | Nature Medicine | 2018 | 393 |
| 47 | Risk Factors For Rate of Decline in Forced Expiratory Volume in One Second in Children and Adolescents with Cystic Fibrosis | Journal of Pediatrics | 2007 | 384 |
| 48 | The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient? | Diabetes | 2000 | 379 |
| 49 | Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome | Pediatric Research | 2010 | 379 |
| 50 | Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005 | Cancer | 2009 | 371 |
