| # | Title | Journal | Year | Citations |
|---|
| 1 | Microbial translocation is a cause of systemic immune activation in chronic HIV infection | Nature Medicine | 2006 | 3,107 |
| 2 | National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report | Biology of Blood and Marrow Transplantation | 2015 | 2,636 |
| 3 | Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2011 | 2,434 |
| 4 | Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis | American Journal of Medicine | 2009 | 2,253 |
| 5 | Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,978 |
| 6 | Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis | Lancet Infectious Diseases, The | 2017 | 1,559 |
| 7 | HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation | Nature Medicine | 2009 | 1,519 |
| 8 | Origins of circulating endothelial cells and endothelial outgrowth from blood | Journal of Clinical Investigation | 2000 | 1,370 |
| 9 | Frailty: implications for clinical practice and public health | Lancet, The | 2019 | 1,341 |
| 10 | Long-Term Consequences of Kidney Donation | New England Journal of Medicine | 2009 | 1,168 |
| 11 | Coronary-Artery Revascularization before Elective Major Vascular Surgery | New England Journal of Medicine | 2004 | 1,166 |
| 12 | Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society | Diabetes Care | 2013 | 1,125 |
| 13 | Extended Virulence Genotypes ofEscherichia coliStrains from Patients with Urosepsis in Relation to Phylogeny and Host Compromise | Journal of Infectious Diseases | 2000 | 1,091 |
| 14 | Familial Clustering of Diabetic Kidney Disease | New England Journal of Medicine | 1989 | 976 |
| 15 | Oxygen free radicals in ischemic acute renal failure in the rat. | Journal of Clinical Investigation | 1984 | 928 |
| 16 | Shared Risk Factors in Cardiovascular Disease and Cancer | Circulation | 2016 | 926 |
| 17 | Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage | American Journal of Kidney Diseases | 1992 | 924 |
| 18 | Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study | Microbiome | 2017 | 901 |
| 19 | Effects of adenosine on human coronary arterial circulation. | Circulation | 1990 | 834 |
| 20 | Ferritin: a cytoprotective antioxidant strategem of endothelium | Journal of Biological Chemistry | 1992 | 812 |
| 21 | PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection | Journal of Experimental Medicine | 2006 | 808 |
| 22 | The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study | BMJ: British Medical Journal | 2010 | 807 |
| 23 | Nonalcoholic Steatohepatitis | JAMA - Journal of the American Medical Association | 2020 | 784 |
| 24 | Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality | JAMA - Journal of the American Medical Association | 2014 | 760 |
| 25 | Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community | Journal of the American College of Cardiology | 2003 | 750 |
| 26 | C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor | Blood | 1993 | 746 |
| 27 | Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications | Diabetes Care | 2002 | 745 |
| 28 | Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part II: Definition. A Consensus Statement of the International Society for Heart and Lung Transplantation | Journal of Heart and Lung Transplantation | 2005 | 724 |
| 29 | Cognitive Dysfunction and Diabetes Mellitus | Endocrine Reviews | 2008 | 670 |
| 30 | Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal | Nature Immunology | 2009 | 659 |
| 31 | Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem | Microbes and Infection | 2003 | 649 |
| 32 | Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. | Journal of Clinical Investigation | 1992 | 644 |
| 33 | Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats | Kidney International | 1984 | 636 |
| 34 | Executive Summary: Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | 2011 | 635 |
| 35 | The new liver allocation system: Moving toward evidence-based transplantation policy | Liver Transplantation | 2002 | 632 |
| 36 | Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea | Journal of Clinical Gastroenterology | 2010 | 595 |
| 37 | From Vulnerable Plaque to Vulnerable Patient—Part III: Executive Summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force Report | American Journal of Cardiology | 2006 | 594 |
| 38 | Standardized Frozen Preparation for Transplantation of Fecal Microbiota for Recurrent Clostridium difficile Infection | American Journal of Gastroenterology | 2012 | 583 |
| 39 | Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 574 |
| 40 | A controlled trial of propafenone for treatment of frequent and repetitive ventricular premature complexes | American Journal of Cardiology | 1984 | 571 |
| 41 | Frailty and Risk of Falls, Fracture, and Mortality in Older Women: The Study of Osteoporotic Fractures | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2007 | 569 |
| 42 | Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections | Blood | 2008 | 562 |
| 43 | Pulmonary arterial hypertension: pathogenesis and clinical management | BMJ: British Medical Journal | 2018 | 553 |
| 44 | Proposal for a New Inclusive Designation for Extraintestinal Pathogenic Isolates ofEscherichia coli:ExPEC | Journal of Infectious Diseases | 2000 | 540 |
| 45 | Transplantation of discordant xenografts: a review of progress | Trends in Immunology | 1990 | 533 |
| 46 | Thyroid hormone action at the cellular level | Science | 1979 | 512 |
| 47 | Cystic Fibrosis–Related Diabetes: Current Trends in Prevalence, Incidence, and Mortality | Diabetes Care | 2009 | 510 |
| 48 | Heterogeneity of mucin gene expression in normal and neoplastic tissues | Cancer Research | 1993 | 510 |
| 49 | Paved With Good Intentions: Do Public Health and Human Service Providers Contribute to Racial/Ethnic Disparities in Health? | American Journal of Public Health | 2003 | 487 |
| 50 | Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure | Nature Communications | 2020 | 466 |
