| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes | Blood | 2009 | 3,864 |
| 2 | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease | Nature Genetics | 2014 | 1,685 |
| 3 | Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1 | Nature Genetics | 1993 | 1,673 |
| 4 | POSITIVE ANDNEGATIVESELECTION OFT CELLS | Annual Review of Immunology | 2003 | 1,321 |
| 5 | Trinucleotide Repeat Disorders | Annual Review of Neuroscience | 2007 | 1,289 |
| 6 | Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue | Journal of Clinical Apheresis | 2019 | 1,263 |
| 7 | The chromosomal basis of human neoplasia | Science | 1983 | 1,111 |
| 8 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 9 | Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program | Clinical Chemistry | 2006 | 1,057 |
| 10 | Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see) | Nature Reviews Immunology | 2014 | 1,043 |
| 11 | Dynamic FoxO transcription factors | Journal of Cell Science | 2007 | 991 |
| 12 | Ataxin-1 Nuclear Localization and Aggregation | Cell | 1998 | 965 |
| 13 | Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics | Blood | 2011 | 926 |
| 14 | Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14 | Science | 1992 | 904 |
| 15 | T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse | Journal of Experimental Medicine | 2011 | 881 |
| 16 | Normalizing the environment recapitulates adult human immune traits in laboratory mice | Nature | 2016 | 848 |
| 17 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia | Neuron | 1998 | 811 |
| 18 | Nonalcoholic Steatohepatitis | JAMA - Journal of the American Medical Association | 2020 | 784 |
| 19 | Analytical Characteristics of High-Sensitivity Cardiac Troponin Assays | Clinical Chemistry | 2012 | 730 |
| 20 | IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells | Journal of Immunology | 2007 | 709 |
| 21 | Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs | Nature Communications | 2015 | 693 |
| 22 | RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia | Nature Medicine | 2004 | 643 |
| 23 | Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells | Nature Immunology | 2013 | 621 |
| 24 | PVT1 dependence in cancer with MYC copy-number increase | Nature | 2014 | 617 |
| 25 | Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial | Lancet Respiratory Medicine,the | 2015 | 614 |
| 26 | National Academy of Clinical Biochemistry Standards of Laboratory Practice: Recommendations for the Use of Cardiac Markers in Coronary Artery Diseases | Clinical Chemistry | 1999 | 599 |
| 27 | Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance | Cell | 2015 | 584 |
| 28 | Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction | Nature | 2015 | 581 |
| 29 | SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat | Cell | 1995 | 567 |
| 30 | Mendelian randomization of blood lipids for coronary heart disease | European Heart Journal | 2015 | 567 |
| 31 | Glycerol monolaurate prevents mucosal SIV transmission | Nature | 2009 | 563 |
| 32 | A Strong Dose-Response Relation Between Serum Concentrations of Persistent Organic Pollutants and Diabetes: Results from the National Health and Examination Survey 1999-2002 | Diabetes Care | 2006 | 557 |
| 33 | Central tolerance: learning self-control in the thymus | Nature Reviews Immunology | 2005 | 549 |
| 34 | Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation | Journal of Immunology | 2005 | 540 |
| 35 | A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 | Nature Genetics | 2010 | 539 |
| 36 | Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures | Nature | 1997 | 531 |
| 37 | Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data | BMJ, The | 2014 | 528 |
| 38 | Detectable clonal mosaicism and its relationship to aging and cancer | Nature Genetics | 2012 | 519 |
| 39 | Determination of 19 Cardiac Troponin I and T Assay 99th Percentile Values from a Common Presumably Healthy Population | Clinical Chemistry | 2012 | 494 |
| 40 | Antioxidant functions of phytic acid | Free Radical Biology and Medicine | 1990 | 493 |
| 41 | Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I | Nature Genetics | 1993 | 489 |
| 42 | Autophagy delays apoptotic death in breast cancer cells following DNA damage | Cell Death and Differentiation | 2007 | 475 |
| 43 | Expression of Dmrt1 in the Genital Ridge of Mouse and Chicken Embryos Suggests a Role in Vertebrate Sexual Development | Developmental Biology | 1999 | 461 |
| 44 | Identification of a novel population of Langerin+ dendritic cells | Journal of Experimental Medicine | 2007 | 453 |
| 45 | Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells | Journal of Experimental Medicine | 2003 | 437 |
| 46 | Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse | Carcinogenesis | 1988 | 435 |
| 47 | High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study | Lancet, The | 2015 | 422 |
| 48 | Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells | Science | 2015 | 421 |
| 49 | γ-Glutamyltransferase Is a Predictor of Incident Diabetes and Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study | Clinical Chemistry | 2003 | 409 |
| 50 | Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8 | Nature Genetics | 2006 | 408 |
