| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia | New England Journal of Medicine | 1997 | 5,128 |
| 3 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | PLoS Medicine | 2007 | 3,710 |
| 4 | Global Prevalence and Major Risk Factors of Diabetic Retinopathy | Diabetes Care | 2012 | 3,439 |
| 5 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 6 | Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma | Science | 1996 | 2,548 |
| 7 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 8 | Use of intensive care at the end of life in the United States: An epidemiologic study* | Critical Care Medicine | 2004 | 1,732 |
| 9 | Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration | International Journal of Surgery | 2014 | 1,698 |
| 10 | Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Nature Genetics | 2007 | 1,633 |
| 11 | Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18. | Journal of Clinical Oncology | 1997 | 1,616 |
| 12 | Cleft lip and palate: understanding genetic and environmental influences | Nature Reviews Genetics | 2011 | 1,435 |
| 13 | Worldwide burden of HIV in transgender women: a systematic review and meta-analysis | Lancet Infectious Diseases, The | 2013 | 1,212 |
| 14 | A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants | Nature Genetics | 2016 | 1,167 |
| 15 | Disparities and access to healthy food in the United States: A review of food deserts literature | Health and Place | 2010 | 1,156 |
| 16 | THE MULTICENTER AIDS COHORT STUDY: RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTS | American Journal of Epidemiology | 1987 | 1,111 |
| 17 | Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults | JAMA - Journal of the American Medical Association | 2014 | 1,072 |
| 18 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 19 | Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults | Circulation | 2005 | 1,067 |
| 20 | Effect of Weight Loss With Lifestyle Intervention on Risk of Diabetes | Diabetes Care | 2006 | 1,050 |
| 21 | The State of US Health, 1990-2016 | JAMA - Journal of the American Medical Association | 2018 | 1,042 |
| 22 | IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia | Nature Medicine | 2008 | 1,040 |
| 23 | Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study | American Journal of Epidemiology | 1996 | 1,016 |
| 24 | Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies | British Journal of Psychiatry | 2013 | 932 |
| 25 | Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update | Cancer | 1983 | 924 |
| 26 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial | Lancet Oncology, The | 2007 | 915 |
| 27 | Suicide and Suicide Risk in Lesbian, Gay, Bisexual, and Transgender Populations: Review and Recommendations | Journal of Homosexuality | 2010 | 914 |
| 28 | Suicidality and Depression Disparities Between Sexual Minority and Heterosexual Youth: A Meta-Analytic Review | Journal of Adolescent Health | 2011 | 901 |
| 29 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Lancet, The | 2018 | 858 |
| 30 | Adenovirus-Associated Defective Virus Particles | Science | 1965 | 850 |
| 31 | Five Versus More Than Five Years of Tamoxifen Therapy for Breast Cancer Patients With Negative Lymph Nodes and Estrogen Receptor-Positive Tumors | Journal of the National Cancer Institute | 1996 | 828 |
| 32 | KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma | Nature Medicine | 1996 | 819 |
| 33 | Percutaneous Transluminal Coronary Angioplasty in 1985–1986 and 1977–1981 | New England Journal of Medicine | 1988 | 812 |
| 34 | Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03 | Journal of Clinical Oncology | 2009 | 796 |
| 35 | Risk of Mortality Following Clinical Fractures | Osteoporosis International | 2000 | 790 |
| 36 | Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer | New England Journal of Medicine | 2021 | 764 |
| 37 | Association Between Palliative Care and Patient and Caregiver Outcomes | JAMA - Journal of the American Medical Association | 2016 | 762 |
| 38 | Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes | Diabetes | 2005 | 755 |
| 39 | Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis | JAMA - Journal of the American Medical Association | 2019 | 753 |
| 40 | Long-Term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD) | Biological Psychiatry | 2004 | 746 |
| 41 | Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia | Journal of Clinical Endocrinology and Metabolism | 2007 | 732 |
| 42 | National Sleep Foundation's sleep quality recommendations: first report | Sleep Health | 2017 | 729 |
| 43 | Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study | Journal of the American College of Cardiology | 2006 | 727 |
| 44 | New loci associated with kidney function and chronic kidney disease | Nature Genetics | 2010 | 710 |
| 45 | Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation | Nature Nanotechnology | 2010 | 698 |
| 46 | Inflammatory markers in population studies of aging | Ageing Research Reviews | 2011 | 673 |
| 47 | Validation Studies for Models Projecting the Risk of Invasive and Total Breast Cancer Incidence | Journal of the National Cancer Institute | 1999 | 671 |
| 48 | Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis | International Journal of Cancer | 2007 | 648 |
| 49 | Cross-Species Virus Transmission and the Emergence of New Epidemic Diseases | Microbiology and Molecular Biology Reviews | 2008 | 648 |
| 50 | Development of Questionnaire to Examine Relationship of Physical Activity and Diabetes in Pima Indians | Diabetes Care | 1990 | 641 |
