| # | Title | Journal | Year | Citations |
|---|
| 1 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,696 |
| 2 | Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group | Critical Care | 2004 | 5,531 |
| 3 | A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia | New England Journal of Medicine | 1997 | 5,128 |
| 4 | Gait Speed and Survival in Older Adults | JAMA - Journal of the American Medical Association | 2011 | 3,254 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 7 | Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma | Science | 1996 | 2,548 |
| 8 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 9 | The cardiovascular health study: Design and rationale | Annals of Epidemiology | 1991 | 2,407 |
| 10 | The Mutational Landscape of Head and Neck Squamous Cell Carcinoma | Science | 2011 | 2,225 |
| 11 | Mechanisms of Bone Metastasis | New England Journal of Medicine | 2004 | 2,134 |
| 12 | Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes | Diabetes | 2002 | 1,975 |
| 13 | Detection and localization of surgically resectable cancers with a multi-analyte blood test | Science | 2018 | 1,872 |
| 14 | Head and neck cancer | Lancet, The | 2008 | 1,732 |
| 15 | A Bayesian Method for the Induction of Probabilistic Networks from Data | Machine Learning | 1992 | 1,649 |
| 16 | Negative inotropic effects of cytokines on the heart mediated by nitric oxide | Science | 1992 | 1,635 |
| 17 | Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Nature Genetics | 2007 | 1,633 |
| 18 | Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of Americaa | Clinical Infectious Diseases | 2013 | 1,593 |
| 19 | Age-specific Incidence Rates of Myocardial Infarction and Angina in Women with Systemic Lupus Erythematosus: Comparison with the Framingham Study | American Journal of Epidemiology | 1997 | 1,591 |
| 20 | Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis | Nature Chemical Biology | 2017 | 1,589 |
| 21 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 22 | Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections | American Journal of Gastroenterology | 2013 | 1,413 |
| 23 | Structure and signalling in the IL-17 receptor family | Nature Reviews Immunology | 2009 | 1,207 |
| 24 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
| 25 | B cells are associated with survival and immunotherapy response in sarcoma | Nature | 2020 | 1,158 |
| 26 | Chronic pancreatitis: Diagnosis, classification, and new genetic developments | Gastroenterology | 2001 | 1,087 |
| 27 | Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells | Circulation | 1998 | 1,005 |
| 28 | Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study | Journal of Applied Physiology | 2001 | 976 |
| 29 | Epidemiology of severe sepsis | Virulence | 2014 | 949 |
| 30 | Prognosis and Outcomes of Patients With Community-Acquired Pneumonia | JAMA - Journal of the American Medical Association | 1996 | 945 |
| 31 | Skeletal Muscle Lipid Content and Insulin Resistance: Evidence for a Paradox in Endurance-Trained Athletes | Journal of Clinical Endocrinology and Metabolism | 2001 | 939 |
| 32 | High-Dose Interferon Alfa-2b Significantly Prolongs Relapse-Free and Overall Survival Compared With the GM2-KLH/QS-21 Vaccine in Patients With Resected Stage IIB-III Melanoma: Results of Intergroup Trial E1694/S9512/C509801 | Journal of Clinical Oncology | 2001 | 907 |
| 33 | Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults | JAMA Pediatrics | 2017 | 893 |
| 34 | Executive Summary: Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of Americaa | Clinical Infectious Diseases | 2013 | 870 |
| 35 | Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma | JAMA - Journal of the American Medical Association | 2016 | 857 |
| 36 | Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. | BMJ: British Medical Journal | 1990 | 856 |
| 37 | Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat | Diabetes | 1997 | 856 |
| 38 | Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy | New England Journal of Medicine | 2012 | 851 |
| 39 | Fuel selection in human skeletal muscle in insulin resistance: a reexamination | Diabetes | 2000 | 849 |
| 40 | Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial | Lancet, The | 2008 | 784 |
| 41 | The IL-17 Family of Cytokines in Health and Disease | Immunity | 2019 | 773 |
| 42 | Sickle cell disease | Nature Reviews Disease Primers | 2018 | 764 |
| 43 | Association Between Palliative Care and Patient and Caregiver Outcomes | JAMA - Journal of the American Medical Association | 2016 | 762 |
| 44 | Fat, fibre and cancer risk in African Americans and rural Africans | Nature Communications | 2015 | 761 |
| 45 | Deficiency of Subsarcolemmal Mitochondria in Obesity and Type 2 Diabetes | Diabetes | 2005 | 755 |
| 46 | Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients | Science | 2021 | 746 |
| 47 | Estimating Hip Fracture Morbidity, Mortality and Costs | Journal of the American Geriatrics Society | 2003 | 744 |
| 48 | Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease | Immunology | 2010 | 738 |
| 49 | Specific HIV integration sites are linked to clonal expansion and persistence of infected cells | Science | 2014 | 722 |
| 50 | Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content | Journal of Applied Physiology | 2000 | 713 |
