| IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia | Nature Medicine | 2008 | 929 |
| Targeting mitochondria | Accounts of Chemical Research | 2008 | 495 |
| Association of radiographic emphysema and airflow obstruction with lung cancer | American Journal of Respiratory and Critical Care Medicine | 2008 | 364 |
| Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease | PLoS ONE | 2008 | 344 |
| Pulmonary complications of sickle cell disease | New England Journal of Medicine | 2008 | 322 |
| Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis | American Journal of Respiratory and Critical Care Medicine | 2008 | 293 |
| Costs and outcomes of acute kidney injury (AKI) following cardiac surgery | Nephrology Dialysis Transplantation | 2008 | 275 |
| Cytokine-mediated regulation of antimicrobial proteins | Nature Reviews Immunology | 2008 | 263 |
| Sleep-disordered breathing and cardiovascular disease: an outcome-based definition of hypopneas | American Journal of Respiratory and Critical Care Medicine | 2008 | 188 |
| Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1 | Autophagy | 2008 | 179 |
| The Pittsburgh Lung Screening Study (PLuSS): outcomes within 3 years of a first computed tomography scan | American Journal of Respiratory and Critical Care Medicine | 2008 | 173 |
| Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making | Current Opinion in Critical Care | 2008 | 172 |
| A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis | American Journal of Pathology | 2008 | 167 |
| Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia | Annals of Emergency Medicine | 2008 | 160 |
| Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O(2) saturation response | Intensive Care Medicine | 2008 | 147 |
| Acute kidney injury | Critical Care Medicine | 2008 | 144 |
| Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study | Diabetes Care | 2008 | 137 |
| Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest | Resuscitation | 2008 | 137 |
| Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester | Journal of Cerebral Blood Flow and Metabolism | 2008 | 133 |
| Growth of intensive care unit resource use and its estimated cost in Medicare | Critical Care Medicine | 2008 | 110 |
| Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory | Critical Care | 2008 | 105 |
| Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 104 |
| Definition and classification of acute kidney injury | Nephron Clinical Practice | 2008 | 103 |
| Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis | FASEB Journal | 2008 | 102 |
| Longitudinal change in the BODE index predicts mortality in severe emphysema | American Journal of Respiratory and Critical Care Medicine | 2008 | 97 |
