| Heme oxygenase-1: unleashing the protective properties of heme | Trends in Immunology | 2003 | 975 |
| The epidemiology of severe sepsis in children in the United States | American Journal of Respiratory and Critical Care Medicine | 2003 | 739 |
| Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 | Nature | 2003 | 724 |
| Aspiration pneumonia and dysphagia in the elderly | Chest | 2003 | 604 |
| Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema | Nature | 2003 | 408 |
| Adrenal insufficiency during septic shock | Critical Care Medicine | 2003 | 349 |
| Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses | Critical Care Medicine | 2003 | 313 |
| Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress | Journal of Biological Chemistry | 2003 | 241 |
| Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies | Arthritis and Rheumatism | 2003 | 227 |
| Gastric versus post-pyloric feeding: a systematic review | Critical Care | 2003 | 224 |
| Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis | Critical Care Medicine | 2003 | 216 |
| Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects | American Journal of Pathology | 2003 | 189 |
| Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1 | Journal of Experimental Medicine | 2003 | 185 |
| Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure | Intensive Care Medicine | 2003 | 122 |
| Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation | Journal of Experimental Medicine | 2003 | 122 |
| Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit | Journal of Neurophysiology | 2003 | 115 |
| Controlled gene delivery system based on thermosensitive biodegradable hydrogel | Pharmaceutical Research | 2003 | 112 |
| Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway | Journal of Biological Chemistry | 2003 | 107 |
| Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome | Gastroenterology | 2003 | 100 |
| Drotrecogin alfa (activated) treatment of older patients with severe sepsis | Clinical Infectious Diseases | 2003 | 92 |
| Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers | Journal of Pharmacology and Experimental Therapeutics | 2003 | 91 |
| A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma | Journal of Neurochemistry | 2003 | 87 |
| Feeding the hemodynamically unstable patient: a critical evaluation of the evidence | Nutrition in Clinical Practice | 2003 | 81 |
| Probing the limits of arterial pulse contour analysis to predict preload responsiveness | Anesthesia and Analgesia | 2003 | 74 |
| Acid-base and electrolyte analysis in critically ill patients: are we ready for the new millennium? | Current Opinion in Critical Care | 2003 | 70 |
