| # | Title | Journal | Year | Citations |
|---|
| 1 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 16,554 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study | Lancet, The | 2020 | 3,119 |
| 4 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 5 | Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis | Nature Chemical Biology | 2017 | 1,589 |
| 6 | Acute kidney injury | Lancet, The | 2012 | 1,574 |
| 7 | RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis | Critical Care | 2006 | 1,246 |
| 8 | Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine | Intensive Care Medicine | 2014 | 1,240 |
| 9 | The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis | Intensive Care Medicine | 2010 | 1,180 |
| 10 | Acute kidney injury | Lancet, The | 2019 | 950 |
| 11 | Epidemiology of severe sepsis | Virulence | 2014 | 949 |
| 12 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 13 | The Epidemiology of Severe Sepsis in Children in the United States | American Journal of Respiratory and Critical Care Medicine | 2003 | 875 |
| 14 | Sepsis: a roadmap for future research | Lancet Infectious Diseases, The | 2015 | 827 |
| 15 | Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury | JAMA - Journal of the American Medical Association | 2016 | 819 |
| 16 | Esophageal Doppler monitoring predicts fluid responsiveness in critically ill ventilated patients | Intensive Care Medicine | 2005 | 777 |
| 17 | Costs associated with delirium in mechanically ventilated patients* | Critical Care Medicine | 2004 | 766 |
| 18 | Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis | JAMA - Journal of the American Medical Association | 2019 | 753 |
| 19 | Aspiration Pneumonia and Dysphagia in the Elderly | Chest | 2003 | 741 |
| 20 | Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts | JAMA - Journal of the American Medical Association | 2014 | 705 |
| 21 | The far-reaching scope of neuroinflammation after traumatic brain injury | Nature Reviews Neurology | 2017 | 687 |
| 22 | Understanding the Inflammatory Cytokine Response in Pneumonia and Sepsis | Archives of Internal Medicine | 2007 | 664 |
| 23 | PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals | Cell | 2017 | 589 |
| 24 | Targeting Mitochondria | Accounts of Chemical Research | 2008 | 560 |
| 25 | A descriptive study of children dying in the pediatric intensive care unit after withdrawal of life-sustaining treatment* | Pediatric Critical Care Medicine | 2004 | 557 |
| 26 | Pain processing during three levels of noxious stimulation produces differential patterns of central activity | Pain | 1997 | 547 |
| 27 | Hospitalized Community-acquired Pneumonia in the Elderly | American Journal of Respiratory and Critical Care Medicine | 2002 | 537 |
| 28 | Acute kidney injury | Nature Reviews Disease Primers | 2021 | 509 |
| 29 | Critical care delivery in the United States: Distribution of services and compliance with Leapfrog recommendations* | Critical Care Medicine | 2006 | 495 |
| 30 | Acute kidney injury in sepsis | Intensive Care Medicine | 2017 | 490 |
| 31 | COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup | Nature Reviews Nephrology | 2020 | 466 |
| 32 | Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease | JAMA - Journal of the American Medical Association | 2015 | 449 |
| 33 | Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 | JAMA - Journal of the American Medical Association | 2020 | 419 |
| 34 | Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury* | Critical Care Medicine | 2004 | 417 |
| 35 | AKI in the ICU: definition, epidemiology, risk stratification, and outcomes | Kidney International | 2012 | 403 |
| 36 | Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication | American Journal of Respiratory and Critical Care Medicine | 2014 | 402 |
| 37 | Adrenal insufficiency during septic shock* | Critical Care Medicine | 2003 | 399 |
| 38 | Adrenal Insufficiency in the Critically Ill | Chest | 2002 | 390 |
| 39 | Hyperferritinemia and inflammation | International Immunology | 2017 | 385 |
| 40 | Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis | American Journal of Respiratory and Critical Care Medicine | 2008 | 369 |
| 41 | Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses | Critical Care Medicine | 2003 | 364 |
| 42 | Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo | Nature Metabolism | 2022 | 356 |
| 43 | Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 352 |
| 44 | Urinary TIMP-2 and IGFBP7 as Early Biomarkers of Acute Kidney Injury and Renal Recovery following Cardiac Surgery | PLoS ONE | 2014 | 345 |
| 45 | Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery | British Journal of Anaesthesia | 2019 | 342 |
| 46 | Acute kidney injury: what's the prognosis? | Nature Reviews Nephrology | 2011 | 335 |
| 47 | Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery | JAMA - Journal of the American Medical Association | 2015 | 330 |
| 48 | Costs and outcomes of acute kidney injury (AKI) following cardiac surgery | Nephrology Dialysis Transplantation | 2008 | 327 |
| 49 | The Epidemiology of Chronic Critical Illness in the United States* | Critical Care Medicine | 2015 | 314 |
| 50 | Severe Community-acquired Pneumonia | American Journal of Respiratory and Critical Care Medicine | 2002 | 307 |
