| # | Title | Journal | Year | Citations |
|---|
| 1 | Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA | Gene Therapy | 1999 | 1,659 |
| 2 | Graphene-based nanomaterials for drug delivery and tissue engineering | Journal of Controlled Release | 2014 | 1,083 |
| 3 | FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION | Lancet, The | 1989 | 980 |
| 4 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 5 | Gene Therapy Progress and Prospects: Nonviral vectors | Gene Therapy | 2002 | 888 |
| 6 | Clinical Pharmacokinetics of Tacrolimus | Clinical Pharmacokinetics | 1995 | 671 |
| 7 | Nonviral gene therapy: promises and challenges | Gene Therapy | 2000 | 565 |
| 8 | Nonviral Gene Delivery: Principle, Limitations, and Recent Progress | AAPS Journal | 2009 | 559 |
| 9 | Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer | Human Gene Therapy | 2001 | 550 |
| 10 | Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders | Nature Neuroscience | 2018 | 490 |
| 11 | DHEA and DHEA-S: A Review | Journal of Clinical Pharmacology | 1999 | 451 |
| 12 | Clinical Pharmacokinetics of Cyclosporin | Clinical Pharmacokinetics | 1986 | 431 |
| 13 | Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450-2C19 (CYP2C19) Genotype and Clopidogrel Therapy | Clinical Pharmacology and Therapeutics | 2011 | 422 |
| 14 | Drug Metabolism in the Liver | Clinics in Liver Disease | 2017 | 413 |
| 15 | Anticholinergic Activity of 107 Medications Commonly Used by Older Adults | Journal of the American Geriatrics Society | 2008 | 412 |
| 16 | Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system | Critical Care Medicine | 2007 | 376 |
| 17 | Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study | Journal of Chemical Information and Modeling | 2020 | 373 |
| 18 | The Role of the Liver in Sepsis | International Reviews of Immunology | 2014 | 371 |
| 19 | Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats☆ | Neurobiology of Aging | 2000 | 359 |
| 20 | Nonviral gene delivery: What we know and what is next | AAPS Journal | 2007 | 351 |
| 21 | Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference | JAMA Network Open | 2020 | 335 |
| 22 | The N-End Rule Pathway | Annual Review of Biochemistry | 2012 | 326 |
| 23 | Hydrodynamic Gene Delivery: Its Principles and Applications | Molecular Therapy | 2007 | 318 |
| 24 | Nuclear Factor Kappa B: Important Transcription Factor and Therapeutic Target | Journal of Clinical Pharmacology | 1998 | 315 |
| 25 | Hydroporation as the mechanism of hydrodynamic delivery | Gene Therapy | 2004 | 314 |
| 26 | Evidence for a Central Mechanism in Angiotensin Induced Hypertension. | Experimental Biology and Medicine | 1961 | 307 |
| 27 | Characterization of Cationic Liposome-Mediated Gene TransferIn Vivoby Intravenous Administration | Human Gene Therapy | 1997 | 300 |
| 28 | Retrospective evaluation of unanticipated admissions and readmissions after same day surgery and associated costs | Journal of Clinical Anesthesia | 2002 | 298 |
| 29 | A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons | Molecular and Cellular Biology | 2005 | 293 |
| 30 | Comparison of Drug Dosing Recommendations Based on Measured GFR and Kidney Function Estimating Equations | American Journal of Kidney Diseases | 2009 | 292 |
| 31 | Effects of low dose quercetin: Cancer cell‐specific inhibition of cell cycle progression | Journal of Cellular Biochemistry | 2009 | 292 |
| 32 | Development of non-viral vectors for systemic gene delivery | Journal of Controlled Release | 2002 | 280 |
| 33 | ERRγ Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart | Cell Metabolism | 2007 | 274 |
| 34 | Polymeric Micelles: Nanocarriers for Cancer-Targeted Drug Delivery | AAPS PharmSciTech | 2014 | 270 |
| 35 | Role of NF-κB in Regulation of PXR-mediated Gene Expression | Journal of Biological Chemistry | 2006 | 269 |
| 36 | Transplantation of Multiple Abdominal Viscera | JAMA - Journal of the American Medical Association | 1989 | 266 |
| 37 | Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration | Gene Therapy | 1997 | 257 |
| 38 | Efficacy of Valproate Maintenance in Patients With Bipolar Disorder and Alcoholism | Archives of General Psychiatry | 2005 | 255 |
| 39 | Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference | Kidney International | 2020 | 254 |
| 40 | Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome) | Nature Genetics | 2005 | 252 |
| 41 | Anisamide-targeted stealth liposomes: A potent carrier for targeting doxorubicin to human prostate cancer cells | International Journal of Cancer | 2004 | 244 |
| 42 | Neurobehavior disinhibition in childhood predisposes boys to substance use disorder by young adulthood: direct and mediated etiologic pathways | Drug and Alcohol Dependence | 2004 | 228 |
| 43 | Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement | Brain Research | 1998 | 226 |
| 44 | Control of an Outbreak of Infection with the Hypervirulent Clostridium difficile BI Strain in a University Hospital Using a Comprehensive "Bundle" Approach | Clinical Infectious Diseases | 2007 | 224 |
| 45 | Deep Learning for Drug Design: an Artificial Intelligence Paradigm for Drug Discovery in the Big Data Era | AAPS Journal | 2018 | 220 |
| 46 | Validation of the five-drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug-metabolizing enzymes* | Clinical Pharmacology and Therapeutics | 1997 | 219 |
| 47 | Mycophenolic Acid Pharmacodynamics and Pharmacokinetics Provide a Basis for Rational Monitoring Strategies | American Journal of Transplantation | 2003 | 219 |
| 48 | Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report | Journal of Antimicrobial Chemotherapy | 2006 | 216 |
| 49 | Ergot and Its Alkaloids | American Journal of Pharmaceutical Education | 2006 | 216 |
| 50 | Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention | JACC: Cardiovascular Interventions | 2018 | 213 |
