| # | Title | Journal | Year | Citations |
|---|
| 1 | The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research | Psychiatry Research | 1989 | 23,254 |
| 2 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,696 |
| 3 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Critical Care Medicine | 2003 | 5,266 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Gait Speed and Survival in Older Adults | JAMA - Journal of the American Medical Association | 2011 | 3,254 |
| 6 | Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance | Science | 1998 | 2,996 |
| 7 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 8 | Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma | Science | 1996 | 2,548 |
| 9 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 10 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
| 11 | Bone Marrow as a Potential Source of Hepatic Oval Cells | Science | 1999 | 2,274 |
| 12 | High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal | Nature Reviews Immunology | 2005 | 2,218 |
| 13 | Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents | Pediatrics | 2017 | 2,199 |
| 14 | Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes | Diabetes | 2002 | 1,975 |
| 15 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference | Intensive Care Medicine | 2003 | 1,965 |
| 16 | The tumor microenvironment and its role in promoting tumor growth | Oncogene | 2008 | 1,869 |
| 17 | 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression | Nature Neuroscience | 2005 | 1,860 |
| 18 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 19 | Conceptualization and Rationale for Consensus Definitions of Terms in Major Depressive Disorder | Archives of General Psychiatry | 1991 | 1,774 |
| 20 | Melanoma staging: Evidence‐based changes in the American Joint Committee on Cancer eighth edition cancer staging manual | Ca-A Cancer Journal for Clinicians | 2017 | 1,662 |
| 21 | Normative data on Revised Conners Parent and Teacher Rating Scales | Journal of Abnormal Child Psychology | 1978 | 1,642 |
| 22 | The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2014 | 1,638 |
| 23 | Negative inotropic effects of cytokines on the heart mediated by nitric oxide | Science | 1992 | 1,635 |
| 24 | Childhood and Adolescent Depression: A Review of the Past 10 Years. Part I | Journal of the American Academy of Child and Adolescent Psychiatry | 1996 | 1,599 |
| 25 | Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of Americaa | Clinical Infectious Diseases | 2013 | 1,593 |
| 26 | Prevalence and Treatment of Mental Disorders, 1990 to 2003 | New England Journal of Medicine | 2005 | 1,592 |
| 27 | Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice | Immunity | 1995 | 1,545 |
| 28 | Role of CD47 as a Marker of Self on Red Blood Cells | Science | 2000 | 1,505 |
| 29 | Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease OutcomesThe NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 Trial | JAMA - Journal of the American Medical Association | 2006 | 1,499 |
| 30 | Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene | Nature Genetics | 1996 | 1,487 |
| 31 | Cortical control of a prosthetic arm for self-feeding | Nature | 2008 | 1,468 |
| 32 | Reliability and validity of the apathy evaluation scale | Psychiatry Research | 1991 | 1,447 |
| 33 | Time to Treatment and Mortality during Mandated Emergency Care for Sepsis | New England Journal of Medicine | 2017 | 1,433 |
| 34 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 35 | Regression analyses of counts and rates: Poisson, overdispersed Poisson, and negative binomial models. | Psychological Bulletin | 1995 | 1,390 |
| 36 | Sleep Health: Can We Define It? Does It Matter? | Sleep | 2014 | 1,363 |
| 37 | Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma | New England Journal of Medicine | 2014 | 1,331 |
| 38 | RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis | Critical Care | 2006 | 1,246 |
| 39 | Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia | JAMA - Journal of the American Medical Association | 2015 | 1,166 |
| 40 | Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+ T cell dysfunction in melanoma patients | Journal of Experimental Medicine | 2010 | 1,118 |
| 41 | A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder | Molecular Psychiatry | 2008 | 1,107 |
| 42 | Microglial and macrophage polarization—new prospects for brain repair | Nature Reviews Neurology | 2015 | 1,093 |
| 43 | Imaging the premotor areas | Current Opinion in Neurobiology | 2001 | 1,089 |
| 44 | The Long-Term Effects of Exposure to Low Doses of Lead in Childhood | New England Journal of Medicine | 1990 | 1,079 |
| 45 | Heme oxygenase-1: unleashing the protective properties of heme | Trends in Immunology | 2003 | 1,054 |
| 46 | Three-Year Outcomes for Maintenance Therapies in Recurrent Depression | Archives of General Psychiatry | 1990 | 1,047 |
| 47 | Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770 | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,047 |
| 48 | Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages | Blood | 2016 | 1,040 |
| 49 | Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival | Journal of the National Cancer Institute | 1998 | 1,034 |
| 50 | Schizophrenia as a Disorder of Neurodevelopment | Annual Review of Neuroscience | 2002 | 1,026 |
