| # | Title | Journal | Year | Citations |
|---|
| 1 | Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence | Journal of Investigative Dermatology | 2013 | 1,827 |
| 2 | Guidelines for the welfare and use of animals in cancer research | British Journal of Cancer | 2010 | 1,167 |
| 3 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
| 4 | Cationic antiseptics: diversity of action under a common epithet | Journal of Applied Microbiology | 2005 | 912 |
| 5 | Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation | Nature Medicine | 2003 | 798 |
| 6 | Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions | Journal of Pharmaceutical Sciences | 2006 | 736 |
| 7 | Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies | Drug Metabolism Reviews | 2007 | 673 |
| 8 | The influence of surface modification on the cytotoxicity of PAMAM dendrimers | International Journal of Pharmaceutics | 2003 | 655 |
| 9 | Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases | Journal of Pharmaceutical Sciences | 2005 | 638 |
| 10 | Health information-seeking behaviour in adolescence: the place of the internet | Social Science and Medicine | 2005 | 636 |
| 11 | A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System | International Journal of Pharmaceutics | 2006 | 562 |
| 12 | Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science | Annual Review of Pharmacology and Toxicology | 2011 | 548 |
| 13 | Dendrimer–drug interactions | Advanced Drug Delivery Reviews | 2005 | 528 |
| 14 | Hospital Admissions Associated with Adverse Drug Reactions: A Systematic Review of Prospective Observational Studies | Annals of Pharmacotherapy | 2008 | 495 |
| 15 | Plants as sources of new antimicrobials and resistance-modifying agents | Natural Product Reports | 2012 | 385 |
| 16 | Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance | Molecular and Cellular Biology | 2004 | 355 |
| 17 | In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model | Drug Metabolism and Disposition | 2000 | 308 |
| 18 | Prevalence, Incidence and Nature of Prescribing Errors in Hospital Inpatients | Drug Safety | 2009 | 302 |
| 19 | CYP3A4 drug interactions: correlation of 10in vitroprobe substrates | British Journal of Clinical Pharmacology | 1999 | 294 |
| 20 | Bridging the efficacy–effectiveness gap: a regulator's perspective on addressing variability of drug response | Nature Reviews Drug Discovery | 2011 | 293 |
| 21 | Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices | Drug Metabolism Reviews | 1997 | 286 |
| 22 | Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology | Clinical Pharmacology and Therapeutics | 2012 | 278 |
| 23 | Biofilms in vitro and in vivo: do singular mechanisms imply cross-resistance? | Journal of Applied Microbiology | 2002 | 271 |
| 24 | Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data | Drug Metabolism and Disposition | 2010 | 267 |
| 25 | Database analyses for the prediction of in vivo drug-drug interactions from in vitro data | British Journal of Clinical Pharmacology | 2004 | 266 |
| 26 | Prevalence and Nature of Medication Administration Errors in Health Care Settings: A Systematic Review of Direct Observational Evidence | Annals of Pharmacotherapy | 2013 | 260 |
| 27 | Potential Impact of Increased Use of Biocides in Consumer Products on Prevalence of Antibiotic Resistance | Clinical Microbiology Reviews | 2003 | 253 |
| 28 | The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability | Journal of Controlled Release | 2004 | 249 |
| 29 | Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches | Pharmaceutical Research | 2005 | 243 |
| 30 | Extracellular products as mediators of the formation and detachment ofPseudomonas fluorescensbiofilms | FEMS Microbiology Letters | 1998 | 238 |
| 31 | Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials | BMJ: British Medical Journal | 2005 | 233 |
| 32 | Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity | Pharmaceutical Research | 2003 | 231 |
| 33 | From compliance to concordance: barriers to accomplishing a re-framed model of health care interactions | Social Science and Medicine | 2004 | 229 |
| 34 | Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver | Clinical Pharmacology and Therapeutics | 2013 | 228 |
| 35 | Chapter 4 In Vitro Biofilm Models | Advances in Applied Microbiology | 2009 | 222 |
| 36 | Self-Assembly of Heterobimetallic d−f Hybrid Complexes: Sensitization of Lanthanide Luminescence by d-Block Metal-to-Ligand Charge-Transfer Excited States | Journal of the American Chemical Society | 2004 | 212 |
| 37 | In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises | Biochemical Pharmacology | 2006 | 212 |
| 38 | Polyamidoamine Starburst® dendrimers as solubility enhancers | International Journal of Pharmaceutics | 2000 | 211 |
| 39 | The Biofilm Matrix | Biofouling | 2003 | 207 |
| 40 | Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers | American Journal of Physiology - Cell Physiology | 2001 | 205 |
| 41 | GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding | International Journal of Cancer | 2003 | 205 |
| 42 | The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review | BMJ: British Medical Journal | 2004 | 203 |
| 43 | Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes | Pharmaceutical Research | 2004 | 199 |
| 44 | Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix | Radiotherapy and Oncology | 2000 | 197 |
| 45 | Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance | Drug Metabolism and Disposition | 2007 | 193 |
| 46 | HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells | Oncogene | 2007 | 191 |
| 47 | Mucosa-Associated Bacterial Diversity in Relation to Human Terminal Ileum and Colonic Biopsy Samples | Applied and Environmental Microbiology | 2007 | 190 |
| 48 | Impact of concomitant use of DMARDs on the persistence with anti-TNF therapies in patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register | Annals of the Rheumatic Diseases | 2011 | 188 |
| 49 | Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice | PLoS ONE | 2010 | 186 |
| 50 | ZD1839 (‘Iressa’), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model | British Journal of Cancer | 2002 | 178 |
