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| Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells | Nature | 2006 | 1.1K |
| Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells | Cancer Research | 2006 | 1K |
| Asymmetric and symmetric stem-cell divisions in development and cancer | Nature | 2006 | 1K |
| Dose escalation of a curcuminoid formulation | BMC Complementary and Alternative Medicine | 2006 | 828 |
| Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival | Clinical Cancer Research | 2006 | 821 |
| Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing | Nature | 2006 | 793 |
| Feasibility of treating prehypertension with an angiotensin-receptor blocker | New England Journal of Medicine | 2006 | 743 |
| A common variant associated with prostate cancer in European and African populations | Nature Genetics | 2006 | 661 |
| Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction | Journal of Medicinal Chemistry | 2006 | 581 |
| A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells | Nature Cell Biology | 2006 | 492 |
| Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible | Nature Genetics | 2006 | 432 |
| Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS) | Nephrology Dialysis Transplantation | 2006 | 339 |
| Chronic inflammation: a common and important factor in the pathogenesis of neoplasia | Ca-A Cancer Journal for Clinicians | 2006 | 324 |
| Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study | Diabetes Care | 2006 | 322 |
| Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy | Diabetes | 2006 | 312 |
| A pericellular collagenase directs the 3-dimensional development of white adipose tissue | Cell | 2006 | 305 |
| A cancer cell metalloprotease triad regulates the basement membrane transmigration program | Genes and Development | 2006 | 289 |
| Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation | Journal of Cell Biology | 2006 | 285 |
| Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway | Nature Cell Biology | 2006 | 270 |
| Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis | International Journal of Radiation Oncology Biology Physics | 2006 | 264 |
| Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins | Journal of Medicinal Chemistry | 2006 | 257 |
| Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 251 |
| The role of CCL12 in the recruitment of fibrocytes and lung fibrosis | American Journal of Respiratory Cell and Molecular Biology | 2006 | 246 |
| Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation | Molecular Biology of the Cell | 2006 | 242 |
