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| Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy | Journal of Controlled Release | 2012 | 730 |
| Metabolic reconstruction for metagenomic data and its application to the human microbiome | PLoS Computational Biology | 2012 | 730 |
| Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications | Cell Host and Microbe | 2012 | 448 |
| Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma | Hepatology | 2012 | 305 |
| Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing | Nature Biotechnology | 2012 | 256 |
| Suppression of Clostridium difficile in the gastrointestinal tracts of germfree mice inoculated with a murine isolate from the family Lachnospiraceae | Infection and Immunity | 2012 | 201 |
| Diversity of P450 enzymes in the biosynthesis of natural products | Natural Product Reports | 2012 | 196 |
| Bacteria of the human gut microbiome catabolize red seaweed glycans with carbohydrate-active enzyme updates from extrinsic microbes | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 194 |
| Enantiomeric natural products: occurrence and biogenesis | Angewandte Chemie - International Edition | 2012 | 182 |
| Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2012 | 173 |
| Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance | Trends in Microbiology | 2012 | 171 |
| Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates | Science Translational Medicine | 2012 | 117 |
| Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids | Journal of Natural Products | 2012 | 112 |
| The metatranscriptome of a deep-sea hydrothermal plume is dominated by water column methanotrophs and lithotrophs | ISME Journal | 2012 | 109 |
| Stabilization of the murine gut microbiome following weaning | Gut Microbes | 2012 | 86 |
| Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids | Journal of the American Chemical Society | 2012 | 85 |
| Zinc competition among the intestinal microbiota | MBio | 2012 | 83 |
| 110 Is Pet Ownership Associated with Higher Vitamin D? | World Allergy Organization Journal | 2012 | 78 |
| Bioinformatics for the Human Microbiome Project | PLoS Computational Biology | 2012 | 54 |
| Plaque assay for murine norovirus | Journal of Visualized Experiments | 2012 | 53 |
| Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling | Blood | 2012 | 49 |
| Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation | Journal of Virology | 2012 | 48 |
| Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy | Annals of Allergy, Asthma and Immunology | 2012 | 46 |
| Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor | Journal of the American Chemical Society | 2012 | 45 |
