| # | Title | Journal | Year | Citations |
|---|
| 1 | Structural insights into µ-opioid receptor activation | Nature | 2015 | 743 |
| 2 | Mesolimbic dopamine signals the value of work | Nature Neuroscience | 2016 | 644 |
| 3 | EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer | Journal of Clinical Oncology | 2008 | 559 |
| 4 | International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology | Pharmacological Reviews | 2003 | 536 |
| 5 | Comparison of butyrylcholinesterase and acetylcholinesterase | Biochemical Journal | 1989 | 508 |
| 6 | GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling | Cell | 2016 | 443 |
| 7 | Taming the Ketamine Tiger | Anesthesiology | 2010 | 398 |
| 8 | Nomenclature for N-acetyltransferases | Pharmacogenetics and Genomics | 1995 | 369 |
| 9 | G protein-coupled receptor kinases: More than just kinases and not only for GPCRs | | 2012 | 368 |
| 10 | Pharmacogenetics of paraoxonases: a brief review | Naunyn-Schmiedeberg's Archives of Pharmacology | 2004 | 365 |
| 11 | Membrane organization in G‐protein mechanisms | FASEB Journal | 1994 | 344 |
| 12 | Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance | Journal of Neurochemistry | 2002 | 333 |
| 13 | Chemoselection As a Strategy for Organ Preservation in Advanced Oropharynx Cancer: Response and Survival Positively Associated With HPV16 Copy Number | Journal of Clinical Oncology | 2008 | 329 |
| 14 | THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE | Annual Review of Pharmacology and Toxicology | 1997 | 316 |
| 15 | Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice | Chemical Research in Toxicology | 1998 | 307 |
| 16 | Sodium Channel β Subunits: Anything but Auxiliary | Neuroscientist | 2001 | 293 |
| 17 | Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance | Cell Metabolism | 2011 | 292 |
| 18 | Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors | PLoS Biology | 2009 | 271 |
| 19 | Inositol Lipids and Signal Transduction in the Nervous System: An Update | Journal of Neurochemistry | 1992 | 269 |
| 20 | Differential Control of Clustering of the Sodium Channels Nav1.2 and Nav1.6 at Developing CNS Nodes of Ranvier | Neuron | 2001 | 264 |
| 21 | Effects of Buprenorphine Maintenance Dose on μ-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers | Neuropsychopharmacology | 2003 | 264 |
| 22 | Prostaglandin H synthases, nonsteroidal antiinflammatory drugs, and colon cancer | FASEB Journal | 1997 | 254 |
| 23 | Structural basis for nucleotide exchange in heterotrimeric G proteins | Science | 2015 | 250 |
| 24 | Sodium Channel β Subunits Mediate Homophilic Cell Adhesion and Recruit Ankyrin to Points of Cell-Cell Contact | Journal of Biological Chemistry | 2000 | 247 |
| 25 | Normal platelet function | Cancer and Metastasis Reviews | 2017 | 242 |
| 26 | Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice | Circulation Research | 2005 | 238 |
| 27 | Mice Lacking Sodium Channel 1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture | Journal of Neuroscience | 2004 | 225 |
| 28 | N-Terminal Phosphorylation of the Dopamine Transporter Is Required for Amphetamine-Induced Efflux | PLoS Biology | 2004 | 221 |
| 29 | MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys | Journal of Pharmacology and Experimental Therapeutics | 1988 | 220 |
| 30 | Characterization of Sodium Channel α- and β-Subunits in Rat and Mouse Cardiac Myocytes | Circulation | 2001 | 216 |
| 31 | The effect of dietary supplementation of fish oil on experimental myocardial infarction | Prostaglandins | 1980 | 215 |
| 32 | Open-Channel Block by the Cytoplasmic Tail of Sodium Channel β4 as a Mechanism for Resurgent Sodium Current | Neuron | 2005 | 211 |
| 33 | Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells. | Journal of Biological Chemistry | 1994 | 208 |
| 34 | Structure of Gα q -p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs | Science | 2007 | 206 |
| 35 | Ciliary Targeting of Olfactory CNG Channels Requires the CNGB1b Subunit and the Kinesin-2 Motor Protein, KIF17 | Current Biology | 2006 | 204 |
| 36 | Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse | Journal of Steroid Biochemistry and Molecular Biology | 2007 | 200 |
| 37 | Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome | Science Translational Medicine | 2020 | 196 |
| 38 | Pharmacological chaperone for α-crystallin partially restores transparency in cataract models | Science | 2015 | 195 |
| 39 | Neurobiology of Phencyclidine (Sernyl), A Drug With An Unusual Spectrum of Pharmacological Activity | International Review of Neurobiology | 1964 | 189 |
| 40 | Tenascin-R Is a Functional Modulator of Sodium Channel β Subunits | Journal of Biological Chemistry | 1999 | 186 |
| 41 | Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples | Journal of Chromatography A | 2016 | 186 |
| 42 | SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES | Drug Metabolism and Disposition | 2004 | 180 |
| 43 | Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells | Journal of Biological Chemistry | 1994 | 179 |
| 44 | A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2 as Being Important in Exocytosis | Journal of Biological Chemistry | 2000 | 175 |
| 45 | Contactin Associates with Na+Channels and Increases Their Functional Expression | Journal of Neuroscience | 2001 | 175 |
| 46 | A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37 | Cellular Signalling | 1999 | 173 |
| 47 | Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins | Clinical Pharmacology and Therapeutics | 2001 | 171 |
| 48 | Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations | Archives of Biochemistry and Biophysics | 2003 | 171 |
| 49 | Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding | Journal of Biological Chemistry | 2011 | 166 |
| 50 | Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation | Nature Chemical Biology | 2013 | 166 |
