| # | Title | Journal | Year | Citations |
|---|
| 1 | A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C | Hepatology | 2003 | 3,455 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | Sterile inflammation: sensing and reacting to damage | Nature Reviews Immunology | 2010 | 2,469 |
| 4 | Interleukin-8 as a macrophage-derived mediator of angiogenesis | Science | 1992 | 1,989 |
| 5 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 6 | Gene-expression profiles predict survival of patients with lung adenocarcinoma | Nature Medicine | 2002 | 1,788 |
| 7 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 8 | methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles | Genome Biology | 2012 | 1,541 |
| 9 | The CRAPome: a contaminant repository for affinity purification–mass spectrometry data | Nature Methods | 2013 | 1,353 |
| 10 | Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells | Nature | 2006 | 1,217 |
| 11 | Control of pathogens and pathobionts by the gut microbiota | Nature Immunology | 2013 | 1,217 |
| 12 | Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer | Nature Medicine | 2016 | 1,193 |
| 13 | Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma | JAMA Oncology | 2016 | 1,192 |
| 14 | Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry | Nature Immunology | 2010 | 1,125 |
| 15 | MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics | Nature Methods | 2017 | 1,099 |
| 16 | Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span | Cell Metabolism | 2008 | 1,060 |
| 17 | Cancer to bone: a fatal attraction | Nature Reviews Cancer | 2011 | 1,047 |
| 18 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 19 | Characterizing the cancer genome in lung adenocarcinoma | Nature | 2007 | 1,020 |
| 20 | NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis | Science Translational Medicine | 2013 | 1,016 |
| 21 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 22 | ENZYME-LABELED ANTIBODIES: PREPARATION AND APPLICATION FOR THE LOCALIZATION OF ANTIGENS | Journal of Histochemistry and Cytochemistry | 1966 | 975 |
| 23 | Adhesion molecules controlling lymphocyte migration | Cell | 1989 | 926 |
| 24 | SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas | Nature Genetics | 2009 | 862 |
| 25 | Genomic correlates of clinical outcome in advanced prostate cancer | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 839 |
| 26 | Discordant Protein and mRNA Expression in Lung Adenocarcinomas | Molecular and Cellular Proteomics | 2002 | 813 |
| 27 | SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways | Molecular Cell | 2013 | 786 |
| 28 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 29 | Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2011 | 774 |
| 30 | Regulation of transendothelial neutrophil migration by endogenous interleukin-8 | Science | 1991 | 753 |
| 31 | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis | Nature Genetics | 2012 | 692 |
| 32 | Integrative clinical genomics of metastatic cancer | Nature | 2017 | 685 |
| 33 | DNA delivery from polymer matrices for tissue engineering | Nature Biotechnology | 1999 | 651 |
| 34 | SAINT: probabilistic scoring of affinity purification–mass spectrometry data | Nature Methods | 2011 | 647 |
| 35 | Proteogenomics: concepts, applications and computational strategies | Nature Methods | 2014 | 641 |
| 36 | Decreased Collagen Production in Chronologically Aged Skin | American Journal of Pathology | 2006 | 640 |
| 37 | ENZYME-LABELED ANTIBODIES FOR THE LIGHT AND ELECTRON MICROSCOPIC LOCALIZATION OF TISSUE ANTIGENS | Journal of Cell Biology | 1967 | 637 |
| 38 | Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study | Lancet Oncology, The | 2013 | 614 |
| 39 | A Global Protein Kinase and Phosphatase Interaction Network in Yeast | Science | 2010 | 608 |
| 40 | Rapamycin slows aging in mice | Aging Cell | 2012 | 580 |
| 41 | Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance | Nature Medicine | 1999 | 574 |
| 42 | The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism | Cell | 2012 | 561 |
| 43 | DIA-Umpire: comprehensive computational framework for data-independent acquisition proteomics | Nature Methods | 2015 | 561 |
| 44 | EGFR, p16, HPV Titer, Bcl-xL and p53, Sex, and Smoking As Indicators of Response to Therapy and Survival in Oropharyngeal Cancer | Journal of Clinical Oncology | 2008 | 559 |
| 45 | A Genetic Approach to Mammalian Glycan Function | Annual Review of Biochemistry | 2003 | 556 |
| 46 | The Cellular Basis of Kidney Development | Annual Review of Cell and Developmental Biology | 2006 | 537 |
| 47 | Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study | Science Translational Medicine | 2011 | 531 |
| 48 | Glutaminolysis: A Hallmark of Cancer Metabolism | Annual Review of Biomedical Engineering | 2017 | 528 |
| 49 | Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae | Frontiers in Cellular and Infection Microbiology | 2018 | 515 |
| 50 | iProphet: Multi-level Integrative Analysis of Shotgun Proteomic Data Improves Peptide and Protein Identification Rates and Error Estimates | Molecular and Cellular Proteomics | 2011 | 490 |
