# | Title | Journal | Year | Citations |
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1 | Efficient tumour formation by single human melanoma cells | Nature | 2008 | 1,674 |
2 | Mechanisms of Photoaging and Chronological Skin Aging | Archives of Dermatology | 2002 | 1,352 |
3 | Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways | Nature Genetics | 2009 | 1,229 |
4 | Oxidative stress inhibits distant metastasis by human melanoma cells | Nature | 2015 | 964 |
5 | Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia | Cancer Cell | 2006 | 921 |
6 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
7 | Psoriasis | Lancet, The | 2021 | 792 |
8 | Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis | Journal of Immunology | 2011 | 758 |
9 | Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci | Nature Genetics | 2016 | 617 |
10 | Psoriasis | Nature Reviews Disease Primers | 2016 | 585 |
11 | Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized | Cancer Cell | 2010 | 555 |
12 | Overexpression of transforming growth factor alpha in psoriatic epidermis | Science | 1989 | 541 |
13 | Pervasive Sharing of Genetic Effects in Autoimmune Disease | PLoS Genetics | 2011 | 540 |
14 | Lymph protects metastasizing melanoma cells from ferroptosis | Nature | 2020 | 484 |
15 | Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis | Nature Genetics | 2009 | 482 |
16 | Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma | Nature Medicine | 2010 | 436 |
17 | Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis | Nature Medicine | 2009 | 431 |
18 | Looking Older | Archives of Dermatology | 2008 | 397 |
19 | UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 362 |
20 | Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan | Human Molecular Genetics | 1997 | 361 |
21 | Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin | American Journal of Pathology | 2009 | 356 |
22 | Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics | Journal of the American Academy of Dermatology | 2018 | 346 |
23 | Wnt/β-catenin signaling directs multiple stages of tooth morphogenesis | Developmental Biology | 2008 | 340 |
24 | Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2 | Nature Genetics | 2010 | 331 |
25 | Transcriptome Analysis of Psoriasis in a Large Case–Control Sample: RNA-Seq Provides Insights into Disease Mechanisms | Journal of Investigative Dermatology | 2014 | 318 |
26 | Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells | Journal of Experimental Medicine | 2000 | 316 |
27 | Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma | Cancer Cell | 2015 | 316 |
28 | Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis | American Journal of Human Genetics | 2012 | 306 |
29 | Sebaceous carcinoma | Journal of the American Academy of Dermatology | 1995 | 294 |
30 | Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci | American Journal of Human Genetics | 2012 | 290 |
31 | Association analyses identify six new psoriasis susceptibility loci in the Chinese population | Nature Genetics | 2010 | 287 |
32 | IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression | Journal of Immunology | 2011 | 282 |
33 | Cytokines in psoriasis | Cytokine | 2015 | 281 |
34 | Application of Retinol to Human Skin In Vivo Induces Epidermal Hyperplasia and Cellular Retinoid Binding Proteins Characteristic of Retinoic Acid but Without Measurable Retinoic Acid Levels or Irritation | Journal of Investigative Dermatology | 1995 | 277 |
35 | c-Jun–dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid | Journal of Clinical Investigation | 2000 | 270 |
36 | Keratinocyte Overexpression of IL-17C Promotes Psoriasiform Skin Inflammation | Journal of Immunology | 2013 | 260 |
37 | IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis | Journal of Allergy and Clinical Immunology | 2017 | 259 |
38 | IL-36 Promotes Myeloid Cell Infiltration, Activation, and Inflammatory Activity in Skin | Journal of Immunology | 2014 | 245 |
39 | Localization of Psoriasis-Susceptibility Locus PSORS1 to a 60-kb Interval Telomeric to HLA-C | American Journal of Human Genetics | 2000 | 240 |
40 | Loss of functional ELOVL4 depletes very long-chain fatty acids (≥C28) and the unique ω-O-acylceramides in skin leading to neonatal death | Human Molecular Genetics | 2007 | 234 |
41 | Collagen Degradation in Aged/Photodamaged Skin In Vivo and After Exposure to Matrix Metalloproteinase-1 In Vitro | Journal of Investigative Dermatology | 2003 | 213 |
42 | A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: Creation and rationale for inclusion of tumor (T) characteristics | Journal of the American Academy of Dermatology | 2011 | 213 |
43 | Topical N-Acetyl Cysteine and Genistein Prevent Ultraviolet-Light-Induced Signaling That Leads to Photoaging in Human Skin in vivo | Journal of Investigative Dermatology | 2003 | 206 |
44 | Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin | Genome Biology | 2015 | 204 |
45 | Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma | PLoS ONE | 2007 | 199 |
46 | The atypical Spitz tumor of uncertain biologic potential | Cancer | 2009 | 189 |
47 | Retinoic Acid Receptor Gene Expression in Human Skin | Journal of Investigative Dermatology | 1991 | 188 |
48 | Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate | Development (Cambridge) | 2008 | 179 |
49 | C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells | Oncogene | 2008 | 178 |
50 | Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin | Journal of Investigative Dermatology | 2010 | 178 |