| # | Title | Journal | Year | Citations |
|---|
| 1 | Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) | JAMA - Journal of the American Medical Association | 2020 | 3,597 |
| 2 | Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection | Nature Communications | 2014 | 817 |
| 3 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 711 |
| 4 | Hospital Deaths in Patients With Sepsis From 2 Independent Cohorts | JAMA - Journal of the American Medical Association | 2014 | 705 |
| 5 | Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups | Lancet, The | 1993 | 696 |
| 6 | The myofibroblast matrix: implications for tissue repair and fibrosis | Journal of Pathology | 2013 | 560 |
| 7 | Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19 | Science Translational Medicine | 2020 | 491 |
| 8 | Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study | Lancet Respiratory Medicine,the | 2013 | 486 |
| 9 | The emerging world of the fungal microbiome | Trends in Microbiology | 2013 | 485 |
| 10 | Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 439 |
| 11 | Sustaining reductions in catheter related bloodstream infections in Michigan intensive care units: observational study | BMJ: British Medical Journal | 2010 | 432 |
| 12 | Influence of body mass index on the response to asthma controller agents | European Respiratory Journal | 2006 | 411 |
| 13 | The airway microbiome in patients with severe asthma: Associations with disease features and severity | Journal of Allergy and Clinical Immunology | 2015 | 395 |
| 14 | Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 | JAMA Internal Medicine | 2021 | 385 |
| 15 | Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection | MBio | 2013 | 353 |
| 16 | Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. | Journal of Clinical Investigation | 1995 | 347 |
| 17 | Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia | Frontiers in Immunology | 2018 | 343 |
| 18 | Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study | Lancet Respiratory Medicine,the | 2016 | 337 |
| 19 | Exploring the Scope of Post–Intensive Care Syndrome Therapy and Care | Critical Care Medicine | 2014 | 335 |
| 20 | Animal Models of Fibrotic Lung Disease | American Journal of Respiratory Cell and Molecular Biology | 2013 | 332 |
| 21 | Nintedanib in patients with progressive fibrosing interstitial lung diseases—subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial | Lancet Respiratory Medicine,the | 2020 | 331 |
| 22 | Application of a Neutral Community Model To Assess Structuring of the Human Lung Microbiome | MBio | 2015 | 325 |
| 23 | Sex Differences in Severe Pulmonary Emphysema | American Journal of Respiratory and Critical Care Medicine | 2007 | 301 |
| 24 | The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis | American Journal of Respiratory Cell and Molecular Biology | 2006 | 295 |
| 25 | Leukotrienes: Underappreciated Mediators of Innate Immune Responses | Journal of Immunology | 2005 | 269 |
| 26 | Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design | American Journal of Respiratory and Critical Care Medicine | 2016 | 260 |
| 27 | Differential Protein Expression Profiling by iTRAQ−2DLC−MS/MS of Lung Cancer Cells Undergoing Epithelial-Mesenchymal Transition Reveals a Migratory/Invasive Phenotype | Journal of Proteome Research | 2006 | 258 |
| 28 | Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2012 | 223 |
| 29 | AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 | Journal of the American Society of Nephrology: JASN | 2021 | 207 |
| 30 | Neutrophil extracellular traps and thrombosis in COVID-19 | Journal of Thrombosis and Thrombolysis | 2021 | 201 |
| 31 | Extracellular matrix in lung development, homeostasis and disease | Matrix Biology | 2018 | 200 |
| 32 | Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2015 | 195 |
| 33 | PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2008 | 182 |
| 34 | The National Emphysema Treatment Trial (NETT) | American Journal of Respiratory and Critical Care Medicine | 2011 | 180 |
| 35 | Components Necessary for High-Quality Lung Cancer Screening | Chest | 2015 | 179 |
| 36 | Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling | Journal of Experimental Medicine | 2015 | 172 |
| 37 | Readmission and Death After Initial Hospital Discharge Among Patients With COVID-19 in a Large Multihospital System | JAMA - Journal of the American Medical Association | 2021 | 170 |
| 38 | Roles of Periostin in Respiratory Disorders | American Journal of Respiratory and Critical Care Medicine | 2016 | 154 |
| 39 | Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2011 | 152 |
| 40 | Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease | BMJ Open Respiratory Research | 2017 | 151 |
| 41 | Hypersensitivity Pneumonitis | Chest | 2019 | 148 |
| 42 | MMP Mediated Degradation of Type IV Collagen Alpha 1 and Alpha 3 Chains Reflects Basement Membrane Remodeling in Experimental and Clinical Fibrosis – Validation of Two Novel Biomarker Assays | PLoS ONE | 2013 | 145 |
| 43 | Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database | Intensive Care Medicine | 2018 | 145 |
| 44 | Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19 | Intensive Care Medicine | 2021 | 143 |
| 45 | The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice | Journal of Clinical Investigation | 2010 | 138 |
| 46 | Granulocyte-Macrophage Colony-Stimulating Factor in the Innate Immune Response toPneumocystis cariniiPneumonia in Mice | Journal of Immunology | 2000 | 134 |
| 47 | Chronic respiratory diseases: a global view | Lancet Respiratory Medicine,the | 2020 | 130 |
| 48 | NOX Enzymes and Pulmonary Disease | Antioxidants and Redox Signaling | 2009 | 129 |
| 49 | Trends in Tracheostomy for Mechanically Ventilated Patients in the United States, 1993–2012 | American Journal of Respiratory and Critical Care Medicine | 2015 | 126 |
| 50 | Bleomycin-Induced E Prostanoid Receptor Changes Alter Fibroblast Responses to Prostaglandin E2 | Journal of Immunology | 2005 | 123 |
