# | Title | Journal | Year | Citations |
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1 | A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability | Pharmaceutical Research | 1995 | 4,287 |
2 | Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate | Biochemistry | 1988 | 1,597 |
3 | OPM database and PPM web server: resources for positioning of proteins in membranes | Nucleic Acids Research | 2012 | 1,572 |
4 | Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities | Advanced Drug Delivery Reviews | 2003 | 1,270 |
5 | Brand Love | Journal of Marketing | 2012 | 1,102 |
6 | OPM: Orientations of Proteins in Membranes database | Bioinformatics | 2006 | 1,064 |
7 | Prediction of Physicochemical Parameters by Atomic Contributions | Journal of Chemical Information and Computer Sciences | 1999 | 977 |
8 | Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms | Pharmaceutical Research | 1998 | 893 |
9 | Nitric oxide synthase: Aspects concerning structure and catalysis | Cell | 1994 | 847 |
10 | Gastrointestinal uptake of biodegradable microparticles: effect of particle size | Pharmaceutical Research | 1996 | 819 |
11 | Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors | Biomaterials | 2008 | 806 |
12 | Polymorphs, Salts, and Cocrystals: What’s in a Name? | Crystal Growth and Design | 2012 | 767 |
13 | Engineering exosomes as refined biological nanoplatforms for drug delivery | Acta Pharmacologica Sinica | 2017 | 767 |
14 | The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent | Pharmaceutical Research | 1997 | 753 |
15 | Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease | Health and Quality of Life Outcomes | 2004 | 722 |
16 | Solubility Advantage of Pharmaceutical Cocrystals | Crystal Growth and Design | 2009 | 709 |
17 | Molecular Properties of WHO Essential Drugs and Provisional Biopharmaceutical Classification | Molecular Pharmaceutics | 2004 | 691 |
18 | Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate | Journal of Biological Chemistry | 1989 | 630 |
19 | Upper gastrointestinal (GI) pH in young, healthy men and women | Pharmaceutical Research | 1990 | 613 |
20 | Development of polyphosphate parameters for use with the AMBER force field | Journal of Computational Chemistry | 2003 | 604 |
21 | Atomic Physicochemical Parameters for Three-Dimensional Structure-Directed Quantitative Structure-Activity Relationships I. Partition Coefficients as a Measure of Hydrophobicity | Journal of Computational Chemistry | 1986 | 602 |
22 | Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards | European Journal of Pharmaceutics and Biopharmaceutics | 2000 | 588 |
23 | Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor | Journal of Biological Chemistry | 1989 | 516 |
24 | Physicochemical and Physiological Mechanisms for the Effects of Food on Drug Absorption: The Role of Lipids and pH | Journal of Pharmaceutical Sciences | 1997 | 513 |
25 | A Provisional Biopharmaceutical Classification of the Top 200 Oral Drug Products in the United States, Great Britain, Spain, and Japan | Molecular Pharmaceutics | 2006 | 493 |
26 | A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals | Journal of Clinical Pharmacology | 2002 | 492 |
27 | Mass transport Phenomena and Models: Theoretical Concepts | Journal of Pharmaceutical Sciences | 1974 | 479 |
28 | Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells | Clinical Cancer Research | 2010 | 478 |
29 | Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III: Modeling hydrophobic interactions | Journal of Computational Chemistry | 1988 | 462 |
30 | Biopharmaceutics classification system: the scientific basis for biowaiver extensions | Pharmaceutical Research | 2002 | 460 |
31 | Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update | Clinical Pharmacology and Therapeutics | 2017 | 450 |
32 | Polymer degradation and in vitro release of a model protein from poly(d,l-lactide-co-glycolide) nano- and microparticles | Journal of Controlled Release | 2003 | 446 |
33 | Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration | Clinical Pharmacokinetics | 1999 | 432 |
34 | Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. | Journal of Biological Chemistry | 1991 | 421 |
35 | A compartmental absorption and transit model for estimating oral drug absorption | International Journal of Pharmaceutics | 1999 | 401 |
36 | [25] Nitric-oxide synthase assays | Methods in Enzymology | 1994 | 400 |
37 | Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants | Clinical Pharmacology and Therapeutics | 2013 | 397 |
38 | General principles of pharmaceutical solid polymorphism A supramolecular perspective | Advanced Drug Delivery Reviews | 2004 | 373 |
39 | Significance of Root-Mean-Square Deviation in Comparing Three-dimensional Structures of Globular Proteins | Journal of Molecular Biology | 1994 | 370 |
40 | Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport | Journal of Pharmaceutical Sciences | 2000 | 370 |
41 | Physiological Parameters for Oral Delivery and in Vitro Testing | Molecular Pharmaceutics | 2010 | 364 |
42 | Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs | Pharmaceutical Research | 2002 | 362 |
43 | Cancer theranostics: the rise of targeted magnetic nanoparticles | Trends in Biotechnology | 2011 | 362 |
44 | Quantification of Gastrointestinal Liquid Volumes and Distribution Following a 240 mL Dose of Water in the Fasted State | Molecular Pharmaceutics | 2014 | 360 |
45 | Tocilizumab for Treatment of Mechanically Ventilated Patients With COVID-19 | Clinical Infectious Diseases | 2021 | 350 |
46 | Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model | Pharmaceutical Research | 2006 | 344 |
47 | Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs | AAPS Journal | 2009 | 337 |
48 | Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration | Biomaterials | 2010 | 334 |
49 | Contact potential that recognizes the correct folding of globular proteins | Journal of Molecular Biology | 1992 | 333 |
50 | Clinical Outcomes and Adherence to Medications Measured by Claims Data in Patients With Diabetes | Diabetes Care | 2004 | 333 |