| # | Title | Journal | Year | Citations |
|---|
| 1 | Stem cells, cancer, and cancer stem cells | Nature | 2001 | 8,665 |
| 2 | The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure | New England Journal of Medicine | 1999 | 8,093 |
| 3 | Global Burden of Diabetes, 1995-2025: Prevalence, numerical estimates, and projections | Diabetes Care | 1998 | 4,873 |
| 4 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 5 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome | Cell Stem Cell | 2007 | 3,550 |
| 6 | IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 | Diabetes Research and Clinical Practice | 2022 | 2,873 |
| 7 | SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells | Cell | 2005 | 2,815 |
| 8 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 9 | Sterile inflammation: sensing and reacting to damage | Nature Reviews Immunology | 2010 | 2,469 |
| 10 | A reference panel of 64,976 haplotypes for genotype imputation | Nature Genetics | 2016 | 2,421 |
| 11 | Guidelines for the Prevention of Intravascular Catheter-related Infections | Clinical Infectious Diseases | 2011 | 2,242 |
| 12 | In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells | Genes and Development | 2003 | 2,114 |
| 13 | Oncogenic Signaling Pathways in The Cancer Genome Atlas | Cell | 2018 | 2,111 |
| 14 | Phenotypic characterization of human colorectal cancer stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,961 |
| 15 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 16 | Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells | Nature | 2003 | 1,768 |
| 17 | Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study | Hepatology | 2005 | 1,688 |
| 18 | Efficient tumour formation by single human melanoma cells | Nature | 2008 | 1,674 |
| 19 | Diagnosis, Prevention, and Treatment of Catheter-Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 1,604 |
| 20 | Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes | Nature | 2003 | 1,545 |
| 21 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 22 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 23 | Acute respiratory distress syndrome | Nature Reviews Disease Primers | 2019 | 1,364 |
| 24 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 25 | Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use | Nature Genetics | 2019 | 1,307 |
| 26 | Asymmetric and symmetric stem-cell divisions in development and cancer | Nature | 2006 | 1,220 |
| 27 | Targeting potential drivers of COVID-19: Neutrophil extracellular traps | Journal of Experimental Medicine | 2020 | 1,193 |
| 28 | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 | JAMA - Journal of the American Medical Association | 2017 | 1,180 |
| 29 | Hedgehog Signaling and Bmi-1 Regulate Self-renewal of Normal and Malignant Human Mammary Stem Cells | Cancer Research | 2006 | 1,145 |
| 30 | Spatial working memory in humans as revealed by PET | Nature | 1993 | 1,140 |
| 31 | Pulmonary Vein Isolation for Paroxysmal and Persistent Atrial Fibrillation | Circulation | 2002 | 1,047 |
| 32 | Association of Elevated Serum PO4, Ca × PO4 Product, and Parathyroid Hormone with Cardiac Mortality Risk in Chronic Hemodialysis Patients | Journal of the American Society of Nephrology: JASN | 2001 | 1,037 |
| 33 | Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution | Cell | 2009 | 1,036 |
| 34 | Dose escalation of a curcuminoid formulation | BMC Complementary and Alternative Medicine | 2006 | 1,034 |
| 35 | Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials | Lancet Oncology, The | 2020 | 1,034 |
| 36 | NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis | Science Translational Medicine | 2013 | 1,016 |
| 37 | Neutrophil extracellular traps in COVID-19 | JCI Insight | 2020 | 988 |
| 38 | Providing Social Support May Be More Beneficial Than Receiving It | Psychological Science | 2003 | 987 |
| 39 | Th17 cells in human disease | Immunological Reviews | 2008 | 960 |
| 40 | The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells | New England Journal of Medicine | 2007 | 924 |
| 41 | Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate | Nature Medicine | 1997 | 914 |
| 42 | Epidemiology of Constipation in North America: A Systematic Review | American Journal of Gastroenterology | 2004 | 907 |
| 43 | EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research | Nature Methods | 2017 | 886 |
| 44 | Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes | PLoS Biology | 2015 | 868 |
| 45 | Feasibility of Treating Prehypertension with an Angiotensin-Receptor Blocker | New England Journal of Medicine | 2006 | 854 |
| 46 | Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts | Stem Cell Reports | 2014 | 854 |
| 47 | Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection | Nature Communications | 2014 | 817 |
| 48 | rrnDB: improved tools for interpreting rRNA gene abundance in bacteria and archaea and a new foundation for future development | Nucleic Acids Research | 2015 | 817 |
| 49 | The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins | Cell | 1990 | 808 |
| 50 | Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection | Journal of the American College of Cardiology | 2015 | 799 |
