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Top Articles

#TitleJournalYearCitations
1Gut microbiota and intestinal FXR mediate the clinical benefits of metforminNature Medicine2018632
2HMDD v3.0: a database for experimentally supported human microRNA–disease associationsNucleic Acids Research2019603
3Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in ChinaJAMA - Journal of the American Medical Association2015577
4Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunctionNature Communications2015413
5Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndromeNature Medicine2019394
6Regulation of the Pulmonary Circulation in the Fetus and NewbornPhysiological Reviews2010278
7Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated SepsisCell Metabolism2017258
8An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic DiseaseGastroenterology2016254
9The role of hypoxia-inducible factors in metabolic diseasesNature Reviews Endocrinology2019254
10HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory MacrophagesMediators of Inflammation2017228
11Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathwayCardiovascular Research2010194
12Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanismCell Metabolism2021185
13Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injuryNature Communications2018184
14An analysis of human microbe–disease associationsBriefings in Bioinformatics2017173
15The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNAAmerican Journal of Physiology - Cell Physiology2019155
16An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in MiceDiabetes2017151
17Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophyProceedings of the National Academy of Sciences of the United States of America2009150
18Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivoProceedings of the National Academy of Sciences of the United States of America2007149
19Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II−Induced Abdominal Aortic Aneurysm in MiceCirculation Research2012140
20Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamstersActa Pharmaceutica Sinica B2019121
21The biological effect of endogenous sulfur dioxide in the cardiovascular systemEuropean Journal of Pharmacology2011114
22Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosisNature Medicine2017108
23Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting LipolysisDiabetes2017104
24Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2Circulation Research2011103
25Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary HypertensionAmerican Journal of Respiratory Cell and Molecular Biology2016101
26Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose TissueJournal of Biological Chemistry201396
27Structural basis of GPBAR activation and bile acid recognitionNature202096
28Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid MetabolismMSystems201695
29Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemiaJournal of Clinical Investigation201994
30Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targetsBritish Journal of Pharmacology201892
31High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathwaysActa Pharmacologica Sinica201190
32Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complexNature202190
33Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In VitroDiabetes200889
34Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide CatabolismCell Metabolism201989
35Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1Biomaterials201888
36Identification and Analysis of Human Sex-biased MicroRNAsGenomics, Proteomics and Bioinformatics201888
37Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPsMolecular Endocrinology200987
38Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and OsteoarthritisCell Reports201981
39Beta blockers, nitric oxide, and cardiovascular diseaseCurrent Opinion in Pharmacology201380
40Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesisCell Metabolism202180
41ROS and NF-κB but not LXR mediate IL-1β signaling for the downregulation of ATP-binding cassette transporter A1American Journal of Physiology - Cell Physiology200778
42mTOR and the differentiation of mesenchymal stem cellsActa Biochimica Et Biophysica Sinica201178
43Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitroRedox Biology201777
44Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic ratsAtherosclerosis201175
45Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰EBioMedicine201974
46Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injuryNitric Oxide - Biology and Chemistry201373
47CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE−/− miceCardiovascular Research201373
48Increase or Decrease Hydrogen Sulfide Exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese MicePLoS ONE201368
49Structure, function and pharmacology of human itch receptor complexesNature202167
50Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertilityELife201866