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Department of Physiology and Pathophysiology
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top-articles
Department of Physiology and Pathophysiology
341
(top 1%)
papers
12.2K
(top 1%)
citations
55
(top 1%)
h
-index
97
(top 1%)
g
-index
389
all documents
13.6K
doc citations
2.2K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin
Nature Medicine
2018
632
2
HMDD v3.0: a database for experimentally supported human microRNA–disease associations
Nucleic Acids Research
2019
603
3
Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China
JAMA - Journal of the American Medical Association
2015
577
4
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Nature Communications
2015
413
5
Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome
Nature Medicine
2019
394
6
Regulation of the Pulmonary Circulation in the Fetus and Newborn
Physiological Reviews
2010
278
7
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis
Cell Metabolism
2017
258
8
An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
Gastroenterology
2016
254
9
The role of hypoxia-inducible factors in metabolic diseases
Nature Reviews Endocrinology
2019
254
10
HIF1
α
-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages
Mediators of Inflammation
2017
228
11
Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway
Cardiovascular Research
2010
194
12
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
Cell Metabolism
2021
185
13
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
Nature Communications
2018
184
14
An analysis of human microbe–disease associations
Briefings in Bioinformatics
2017
173
15
The
N
6
-methyladenosine (m
6
A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of
STAT1
mRNA
American Journal of Physiology - Cell Physiology
2019
155
16
An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice
Diabetes
2017
151
17
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
Proceedings of the National Academy of Sciences of the United States of America
2009
150
18
Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo
Proceedings of the National Academy of Sciences of the United States of America
2007
149
19
Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II−Induced Abdominal Aortic Aneurysm in Mice
Circulation Research
2012
140
20
Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters
Acta Pharmaceutica Sinica B
2019
121
21
The biological effect of endogenous sulfur dioxide in the cardiovascular system
European Journal of Pharmacology
2011
114
22
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
Nature Medicine
2017
108
23
Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet–Induced Obesity and Insulin Resistance by Inhibiting Lipolysis
Diabetes
2017
104
24
Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2
Circulation Research
2011
103
25
Endothelial and Smooth Muscle Cell Interactions in the Pathobiology of Pulmonary Hypertension
American Journal of Respiratory Cell and Molecular Biology
2016
101
26
Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue
Journal of Biological Chemistry
2013
96
27
Structural basis of GPBAR activation and bile acid recognition
Nature
2020
96
28
Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism
MSystems
2016
95
29
Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia
Journal of Clinical Investigation
2019
94
30
Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets
British Journal of Pharmacology
2018
92
31
High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways
Acta Pharmacologica Sinica
2011
90
32
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Nature
2021
90
33
Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro
Diabetes
2008
89
34
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism
Cell Metabolism
2019
89
35
Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1
Biomaterials
2018
88
36
Identification and Analysis of Human Sex-biased MicroRNAs
Genomics, Proteomics and Bioinformatics
2018
88
37
Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPs
Molecular Endocrinology
2009
87
38
Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis
Cell Reports
2019
81
39
Beta blockers, nitric oxide, and cardiovascular disease
Current Opinion in Pharmacology
2013
80
40
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis
Cell Metabolism
2021
80
41
ROS and NF-κB but not LXR mediate IL-1β signaling for the downregulation of ATP-binding cassette transporter A1
American Journal of Physiology - Cell Physiology
2007
78
42
mTOR and the differentiation of mesenchymal stem cells
Acta Biochimica Et Biophysica Sinica
2011
78
43
Metabolomics analysis reveals that benzo[a]pyrene, a component of PM2.5, promotes pulmonary injury by modifying lipid metabolism in a phospholipase A2-dependent manner in vivo and in vitro
Redox Biology
2017
77
44
Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats
Atherosclerosis
2011
75
45
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰
EBioMedicine
2019
74
46
Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I/R) injury
Nitric Oxide - Biology and Chemistry
2013
73
47
CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE−/− mice
Cardiovascular Research
2013
73
48
Increase or Decrease Hydrogen Sulfide Exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice
PLoS ONE
2013
68
49
Structure, function and pharmacology of human itch receptor complexes
Nature
2021
67
50
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility
ELife
2018
66
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