| # | Title | Journal | Year | Citations |
|---|
| 1 | Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses | BMJ: British Medical Journal | 2003 | 840 |
| 2 | The stepped wedge trial design: a systematic review | BMC Medical Research Methodology | 2006 | 730 |
| 3 | Sequence variants at the TERT-CLPTM1L locus associate with many cancer types | Nature Genetics | 2009 | 572 |
| 4 | Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data | BMJ: British Medical Journal | 2005 | 482 |
| 5 | Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial | Lancet, The | 2000 | 455 |
| 6 | Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study | Lancet, The | 2001 | 455 |
| 7 | Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis | Gut | 2008 | 433 |
| 8 | Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation | Health Technology Assessment | 2007 | 390 |
| 9 | Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy | International Journal of Epidemiology | 2002 | 387 |
| 10 | Use and misuse of process and outcome data in managing performance of acute medical care: avoiding institutional stigma | Lancet, The | 2004 | 387 |
| 11 | Sequence variant on 8q24 confers susceptibility to urinary bladder cancer | Nature Genetics | 2008 | 377 |
| 12 | Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database | BMJ: British Medical Journal | 2000 | 372 |
| 13 | Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer | Nature Genetics | 2009 | 321 |
| 14 | Faecal incontinence after childbirth | BJOG: an International Journal of Obstetrics and Gynaecology | 1997 | 320 |
| 15 | A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness | Health Technology Assessment | 2006 | 305 |
| 16 | A meta-analysis of the association of physical activity with reduced risk of colorectal cancer | Colorectal Disease | 2005 | 286 |
| 17 | Dynamic Relationship between IFN-γ and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load | Journal of Immunology | 2007 | 269 |
| 18 | Uveitis: A Potentially Blinding Disease | Ophthalmologica | 2004 | 251 |
| 19 | Passive smoking exposure and risk of COPD among adults in China: the Guangzhou Biobank Cohort Study | Lancet, The | 2007 | 248 |
| 20 | Effects of redesigned community postnatal care on womens' health 4 months after birth: a cluster randomised controlled trial | Lancet, The | 2002 | 237 |
| 21 | Spinal cord stimulation for complex regional pain syndrome: A systematic review of the clinical and cost-effectiveness literature and assessment of prognostic factors | European Journal of Pain | 2006 | 237 |
| 22 | Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation | Health Technology Assessment | 2008 | 235 |
| 23 | Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling | Health Technology Assessment | 2008 | 232 |
| 24 | Use of process measures to monitor the quality of clinical practice | BMJ: British Medical Journal | 2007 | 229 |
| 25 | A systematic review of tests of empathy in medicine | BMC Medical Education | 2007 | 224 |
| 26 | The rising trend in oesophageal adenocarcinoma and gastric cardia | European Journal of Cancer Prevention | 1992 | 222 |
| 27 | Epidemiology of urinary bladder cancer: from tumor development to patient’s death | World Journal of Urology | 2007 | 221 |
| 28 | The British Childhood Cancer Survivor Study: Objectives, methods, population structure, response rates and initial descriptive information | Pediatric Blood and Cancer | 2008 | 210 |
| 29 | Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL | Blood | 2005 | 209 |
| 30 | The UK case–control study of cerebral oedema complicating diabetic ketoacidosis in children | Diabetologia | 2006 | 209 |
| 31 | Vaccinating healthcare workers against influenza to protect the vulnerable—Is it a good use of healthcare resources?A systematic review of the evidence and an economic evaluation | Vaccine | 2006 | 205 |
| 32 | Treatment of Painful Vertebral Fractures by Kyphoplasty in Patients With Primary Osteoporosis: A Prospective Nonrandomized Controlled Study | Journal of Bone and Mineral Research | 2004 | 201 |
| 33 | Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review | Clinical and Experimental Immunology | 2007 | 194 |
| 34 | Plotting basic control charts: tutorial notes for healthcare practitioners | Quality and Safety in Health Care | 2008 | 188 |
| 35 | Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life | Climacteric | 2006 | 181 |
| 36 | A case-control study of oesophageal adenocarcinoma in women: a preventable disease | British Journal of Cancer | 2000 | 178 |
| 37 | An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessary | Journal of Clinical Epidemiology | 2008 | 173 |
| 38 | Health after childbirth | BJOG: an International Journal of Obstetrics and Gynaecology | 1991 | 172 |
| 39 | ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly | Journal of Clinical Endocrinology and Metabolism | 2009 | 172 |
| 40 | Adjusted indirect comparison may be less biased than direct comparison for evaluating new pharmaceutical interventions | Journal of Clinical Epidemiology | 2008 | 171 |
| 41 | A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer | Nature Genetics | 2010 | 169 |
| 42 | Inclusion of cost effectiveness in licensing requirements of new drugs: the fourth hurdle | BMJ: British Medical Journal | 2004 | 163 |
| 43 | Is Antibiotic Prophylaxis in Surgery a Generally Effective Intervention? | Annals of Surgery | 2009 | 163 |
| 44 | Accidental dural puncture in obstetric patients and long term symptoms. | BMJ: British Medical Journal | 1993 | 158 |
| 45 | Narrow-band imaging flexible cystoscopy in the detection of recurrent urothelial cancer of the bladder | BJU International | 2008 | 156 |
| 46 | Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study | Health Technology Assessment | 2005 | 155 |
| 47 | Spinal Cord Stimulation vs. Conventional Medical Management: A Prospective, Randomized, Controlled, Multicenter Study of Patients with Failed Back Surgery Syndrome (PROCESS Study) | Neuromodulation | 2005 | 151 |
| 48 | The Birmingham Rehabilitation Uptake Maximisation Study (BRUM). Home-based compared with hospital-based cardiac rehabilitation in a multi-ethnic population: cost-effectiveness and patient adherence | Health Technology Assessment | 2007 | 151 |
| 49 | Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain | British Journal of Cancer | 2004 | 150 |
| 50 | The ethics of randomised controlled trials from the perspectives of patients, the public, and healthcare professionals | BMJ: British Medical Journal | 1998 | 149 |
