Department of Medicinal Chemistry and Chemical Biology

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#	Title	Journal	Year	Citations
1	Multivalent glycoconjugates as anti-pathogenic agents	Chemical Society Reviews	2013	464
2	Maximising multivalency effects in protein–carbohydrate interactions	Organic and Biomolecular Chemistry	2009	317
3	Bridging lectin binding sites by multivalent carbohydrates	Chemical Society Reviews	2013	190
4	Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes	Organic and Biomolecular Chemistry	2007	180
5	Intervention with bacterial adhesion by multivalent carbohydrates	Medicinal Research Reviews	2007	154
6	Galectin‐3‐Binding Glycomimetics that Strongly Reduce Bleomycin‐Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition	ChemBioChem	2016	145
7	Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases	Drug Discovery Today	2014	127
8	Structural Insight into the Recognition of the H3K4me3 Mark by the TFIID Subunit TAF3	Structure	2008	123
9	Inactivation of Staphylococcal Phenol Soluble Modulins by Serum Lipoprotein Particles	PLoS Pathogens	2012	106
10	Glucocorticoid‐Loaded Core‐Cross‐Linked Polymeric Micelles with Tailorable Release Kinetics for Targeted Therapy of Rheumatoid Arthritis	Angewandte Chemie - International Edition	2012	102
11	Strong Inhibition of Cholera Toxin by Multivalent GM1 Derivatives	ChemBioChem	2007	101
12	Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip	ChemBioChem	2008	83
13	β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes	Journal of Molecular Biology	2007	75
14	Strong inhibition of cholera toxin binding by galactose dendrimers	Chemical Communications	2007	75
15	Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA	Chemical Communications	2012	73
16	Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound	Journal of the American Chemical Society	2015	70
17	Synthesis and Characterization of Biodegradable Peptide-Based Polymers Prepared by Microwave-Assisted Click Chemistry	Biomacromolecules	2008	69
18	Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors	Journal of Medicinal Chemistry	2012	67
19	Specificity of the Transport of Lipid II by FtsW in Escherichia coli	Journal of Biological Chemistry	2014	67
20	Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray	ChemBioChem	2010	65
21	Optimizing Divalent Inhibitors of Pseudomonas aeruginosa Lectin LecA by Using A Rigid Spacer	Chemistry - A European Journal	2013	65
22	Convenient Preparation of Bactericidal Hydrogels by Covalent Attachment of Stabilized Antimicrobial Peptides Using Thiol–ene Click Chemistry	ACS Macro Letters	2014	64
23	Tuning the Preference of Thiodigalactoside- and Lactosamine-Based Ligands to Galectin-3 over Galectin-1	Journal of Medicinal Chemistry	2013	62
24	The Influence of Ligand Valency on Aggregation Mechanisms for Inhibiting Bacterial Toxins	ChemBioChem	2009	59
25	A new chemical probe for the detection of the cancer-linked galectin-3	Organic and Biomolecular Chemistry	2006	52
26	Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA	ACS Chemical Biology	2015	52
27	Enhanced Membrane Pore Formation through High-Affinity Targeted Antimicrobial Peptides	PLoS ONE	2012	51
28	Carbohydrate Mediated Bacterial Adhesion	Advances in Experimental Medicine and Biology	2011	50
29	Synthesis of Peptide-Based Polymers by Microwave-Assisted Cycloaddition Backbone Polymerization	Biomacromolecules	2007	48
30	Liposome functionalization with copper-free “click chemistry”	Journal of Controlled Release	2015	47
31	Detection of pathogenic Streptococcus suis bacteria using magnetic glycoparticles	Organic and Biomolecular Chemistry	2010	46
32	Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap	Bioorganic and Medicinal Chemistry	2011	43
33	New Insights into Nisin’s Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues	Biochemistry	2016	43
34	Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action	Journal of Medicinal Chemistry	2016	42
35	Resin-Bound Sulfonyl Azides: Efficient Loading and Activation Strategy for the Preparation of the N-Acyl Sulfonamide Linker	Journal of Organic Chemistry	2007	41
36	Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors	Tetrahedron Letters	2009	41
37	Structure of the Tyrosine-sulfated C5a Receptor N Terminus in Complex with Chemotaxis Inhibitory Protein of Staphylococcus aureus	Journal of Biological Chemistry	2009	40
38	Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides	Bioorganic and Medicinal Chemistry	2016	39
39	Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors	Journal of Medicinal Chemistry	2014	38
40	Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy	Nanoscale	2016	37
41	Synthesis and Evaluation of New Thiodigalactoside‐Based Chemical Probes to Label Galectin‐3	ChemBioChem	2009	36
42	Transformation of the amyloidogenic peptide amylin(20–29) into its corresponding peptoid and retropeptoid: Access to both an amyloid inhibitor and template for self-assembled supramolecular tapes	Bioorganic and Medicinal Chemistry Letters	2007	33
43	Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and ‘click’ conjugation	Organic and Biomolecular Chemistry	2008	33
44	Development of Selective Bisubstrate‐Based Inhibitors Against Protein Kinase C (PKC) Isozymes By Using Dynamic Peptide Microarrays	ChemBioChem	2009	33
45	Membrane Permeabilization by Multivalent Anti-Microbial Peptides	Protein and Peptide Letters	2009	33
46	Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides	Biochimica Et Biophysica Acta - Biomembranes	2012	33
47	Main Phenolic Compounds of the Melanin Biosynthesis Pathway in Bruising-Tolerant and Bruising-Sensitive Button Mushroom (Agaricus bisporus) Strains	Journal of Agricultural and Food Chemistry	2013	33
48	Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis	Organic and Biomolecular Chemistry	2007	31
49	Preparation of N^G-Substituted l-Arginine Analogues Suitable for Solid Phase Peptide Synthesis	Journal of Organic Chemistry	2008	30
50	Synthesis and antifungal properties of papulacandin derivatives	Beilstein Journal of Organic Chemistry	2012	30

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