| # | Title | Journal | Year | Citations |
|---|
| 1 | A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak | Brain, Behavior, and Immunity | 2020 | 1,165 |
| 2 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 3 | Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae , an urgent threat to public health | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 942 |
| 4 | Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention | Nature Reviews Gastroenterology and Hepatology | 2021 | 867 |
| 5 | Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression | Journal of Affective Disorders | 2012 | 759 |
| 6 | A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets | Gut | 2012 | 562 |
| 7 | International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management | Journal of Nutrition, Health and Aging | 2018 | 549 |
| 8 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update | Hepatology International | 2019 | 483 |
| 9 | Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management | Journal of Nutrition, Health and Aging | 2019 | 474 |
| 10 | Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil | Gastroenterology | 2013 | 381 |
| 11 | The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals | Nature Genetics | 2016 | 362 |
| 12 | The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke | Journal of the Neurological Sciences | 2010 | 350 |
| 13 | A global scientific strategy to cure hepatitis B | The Lancet Gastroenterology and Hepatology | 2019 | 342 |
| 14 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy | Gastroenterology | 2011 | 304 |
| 15 | The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: A Perspective From Asia | Clinical Infectious Diseases | 2013 | 267 |
| 16 | Covert COVID-19 and false-positive dengue serology in Singapore | Lancet Infectious Diseases, The | 2020 | 256 |
| 17 | Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis | BMJ, The | 2022 | 253 |
| 18 | Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls | Nature | 2019 | 248 |
| 19 | Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring | Nature Communications | 2020 | 245 |
| 20 | Combination of heparin and aspirin is superior to aspirin alone in enhancing live births in patients with recurrent pregnancy loss and positive anti-phospholipid antibodies: a meta-analysis of randomized controlled trials and meta-regression | Rheumatology | 2010 | 221 |
| 21 | COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature | Journal of Thrombosis and Thrombolysis | 2020 | 214 |
| 22 | Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer | Clinical and Experimental Pharmacology and Physiology | 2012 | 203 |
| 23 | Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas | Gut | 2015 | 197 |
| 24 | Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma | Nature Genetics | 2012 | 196 |
| 25 | Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature | Critical Care | 2020 | 192 |
| 26 | Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation | Journal of Clinical Investigation | 2018 | 167 |
| 27 | Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction | European Journal of Heart Failure | 2015 | 160 |
| 28 | The Montreal Cognitive Assessment is superior to the Mini–Mental State Examination in detecting patients at higher risk of dementia | International Psychogeriatrics | 2012 | 155 |
| 29 | Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review | Journal of Rehabilitation Research and Development | 2009 | 154 |
| 30 | Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Respiratory Aerosols Emitted by Patients With Coronavirus Disease 2019 (COVID-19) While Breathing, Talking, and Singing | Clinical Infectious Diseases | 2022 | 143 |
| 31 | How the COVID-19 pandemic will change the future of critical care | Intensive Care Medicine | 2021 | 132 |
| 32 | An Asia-Pacific study on healthcare workers’ perceptions of, and willingness to receive, the COVID-19 vaccination | International Journal of Infectious Diseases | 2021 | 125 |
| 33 | An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing | Nature Communications | 2021 | 124 |
| 34 | Effect of fenugreek (Trigonella foenum-graecumL.) intake on glycemia: a meta-analysis of clinical trials | Nutrition Journal | 2014 | 121 |
| 35 | Fiberoptic Confocal Raman Spectroscopy for Real-Time In Vivo Diagnosis of Dysplasia in Barrett's Esophagus | Gastroenterology | 2014 | 119 |
| 36 | Asian-Pacific perspective on the psychological well-being of healthcare workers during the evolution of the COVID-19 pandemic | BJPsych Open | 2020 | 119 |
| 37 | Whole-genome reconstruction and mutational signatures in gastric cancer | Genome Biology | 2012 | 116 |
| 38 | The Y238X Stop Codon Polymorphism in the Human β-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis | Journal of Infectious Diseases | 2011 | 111 |
| 39 | Surveillance and Correlation of Antibiotic Prescription and Resistance of Gram-Negative Bacteria in Singaporean Hospitals | Antimicrobial Agents and Chemotherapy | 2010 | 108 |
| 40 | A common variant near TGFBR3 is associated with primary open angle glaucoma | Human Molecular Genetics | 2015 | 105 |
| 41 | Ethnicity Modifies the Relationships of Insulin Resistance, Inflammation, and Adiponectin With Obesity in a Multiethnic Asian Population | Diabetes Care | 2011 | 104 |
| 42 | C-reactive Protein, Body Mass Index, and Diabetic Retinopathy | | 2010 | 101 |
| 43 | DLD pillar shape design for efficient separation of spherical and non-spherical bioparticles | Lab on A Chip | 2014 | 100 |
| 44 | Singapore Healthy Older People Everyday (HOPE) Study: Prevalence of Frailty and Associated Factors in Older Adults | Journal of the American Medical Directors Association | 2017 | 99 |
| 45 | Severe Obstructive Sleep Apnea and Outcomes Following Myocardial Infarction | Journal of Clinical Sleep Medicine | 2011 | 97 |
| 46 | Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis | The Lancet Gastroenterology and Hepatology | 2021 | 95 |
| 47 | Genome-wide association study of Parkinson’s disease in East Asians | Human Molecular Genetics | 2017 | 94 |
| 48 | The impact of multidrug resistance in healthcare-associated and nosocomial Gram-negative bacteraemia on mortality and length of stay: cohort study | Clinical Microbiology and Infection | 2012 | 90 |
| 49 | Timing of Recanalization After Intravenous Thrombolysis and Functional Outcomes After Acute Ischemic Stroke | JAMA Neurology | 2013 | 88 |
| 50 | Intracellular Adenosine Triphosphate Deprivation through Lanthanide-Doped Nanoparticles | Journal of the American Chemical Society | 2015 | 88 |
