Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay | Science | 2013 | 982 |
Single-cell sequencing-based technologies will revolutionize whole-organism science | Nature Reviews Genetics | 2013 | 779 |
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs | Nature Medicine | 2013 | 553 |
Replication stress links structural and numerical cancer chromosomal instability | Nature | 2013 | 521 |
Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease | Nature Protocols | 2013 | 447 |
Orbitrap mass spectrometry | Analytical Chemistry | 2013 | 327 |
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes | Nature Medicine | 2013 | 301 |
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits | Nature | 2013 | 192 |
The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype | FASEB Journal | 2013 | 188 |
Application of 'omics technologies to biomarker discovery in inflammatory lung diseases | European Respiratory Journal | 2013 | 174 |
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress | Oncogene | 2013 | 166 |
Sox17 is indispensable for acquisition and maintenance of arterial identity | Nature Communications | 2013 | 163 |
Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke | Journal of Cerebral Blood Flow and Metabolism | 2013 | 151 |
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile | Annals of the Rheumatic Diseases | 2013 | 127 |
MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer | Oncogene | 2013 | 123 |
Thioredoxin and thioredoxin reductase in relation to reversible S-nitrosylation | Antioxidants and Redox Signaling | 2013 | 121 |
High-resolution analysis with novel cell-surface markers identifies routes to iPS cells | Nature | 2013 | 119 |
Genome-wide association study of susceptibility loci for cervical cancer | Journal of the National Cancer Institute | 2013 | 113 |
The challenge of the proteome dynamic range and its implications for in-depth proteomics | Proteomics | 2013 | 112 |
APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase | Cell Death and Disease | 2013 | 108 |
Rapid and deep human proteome analysis by single-dimension shotgun proteomics | Molecular and Cellular Proteomics | 2013 | 107 |
Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione | FASEB Journal | 2013 | 105 |
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters | Nature Structural and Molecular Biology | 2013 | 103 |
Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 100 |
Enzymatic production of 'monoclonal stoichiometric' single-stranded DNA oligonucleotides | Nature Methods | 2013 | 98 |