# | Title | Journal | Year | Citations |
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1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
2 | A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses | Nature Medicine | 2009 | 1,426 |
3 | Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity | Current Opinion in Immunology | 2012 | 1,186 |
4 | The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints | Cancer Discovery | 2015 | 1,180 |
5 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 894 |
6 | Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment | Mayo Clinic Proceedings | 2016 | 832 |
7 | The telomere syndromes | Nature Reviews Genetics | 2012 | 816 |
8 | Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma | JAMA Oncology | 2017 | 750 |
9 | Regulation of Immune Responses by mTOR | Annual Review of Immunology | 2012 | 689 |
10 | Functional normalization of 450k methylation array data improves replication in large cancer studies | Genome Biology | 2014 | 665 |
11 | STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade | Science Translational Medicine | 2015 | 543 |
12 | Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice | Journal of Experimental Medicine | 2005 | 529 |
13 | Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody | Clinical Cancer Research | 2013 | 485 |
14 | Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity | Nature Communications | 2020 | 480 |
15 | Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells | Science | 2016 | 464 |
16 | A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells | Blood | 2008 | 431 |
17 | An In vivo Platform for Translational Drug Development in Pancreatic Cancer | Clinical Cancer Research | 2006 | 407 |
18 | Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non–Small Cell Lung Cancer Treated With Nivolumab | JAMA Oncology | 2019 | 388 |
19 | Targeting adenosine for cancer immunotherapy | | 2018 | 379 |
20 | Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas | Science Translational Medicine | 2015 | 372 |
21 | Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors | Nature Reviews Gastroenterology and Hepatology | 2021 | 370 |
22 | Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review | BMC Public Health | 2012 | 356 |
23 | High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease | Blood | 2010 | 346 |
24 | Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification | Neuron | 2019 | 343 |
25 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma | Annals of Surgery | 2011 | 339 |
26 | mTOR, metabolism, and the regulation of T‐cell differentiation and function | Immunological Reviews | 2012 | 335 |
27 | PD-L1 Expression in the Merkel Cell Carcinoma Microenvironment: Association with Inflammation, Merkel Cell Polyomavirus, and Overall Survival | Cancer Immunology Research | 2013 | 333 |
28 | Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 317 |
29 | Cardiovascular toxicities associated with immune checkpoint inhibitors | Cardiovascular Research | 2019 | 311 |
30 | Telomeres and age-related disease: how telomere biology informs clinical paradigms | Journal of Clinical Investigation | 2013 | 298 |
31 | Mechanisms regulating PD-L1 expression on tumor and immune cells | | 2019 | 291 |
32 | Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer | Nature | 2014 | 284 |
33 | Telomere dysfunction causes alveolar stem cell failure | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 263 |
34 | The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3 | Immunity | 2013 | 260 |
35 | Antagonists of PD-1 and PD-L1 in Cancer Treatment | Seminars in Oncology | 2015 | 259 |
36 | Telomere Length Is a Determinant of Emphysema Susceptibility | American Journal of Respiratory and Critical Care Medicine | 2011 | 228 |
37 | Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer | Nature Genetics | 2015 | 224 |
38 | Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans | Blood | 2012 | 221 |
39 | Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation | Journal of Clinical Oncology | 2009 | 217 |
40 | Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy | Clinical Cancer Research | 2018 | 213 |
41 | Inferring causal molecular networks: empirical assessment through a community-based effort | Nature Methods | 2016 | 209 |
42 | Tumor-Initiating Cells Are Rare in Many Human Tumors | Cell Stem Cell | 2010 | 205 |
43 | Telomerase and idiopathic pulmonary fibrosis | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2012 | 205 |
44 | Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses | Science Translational Medicine | 2020 | 205 |
45 | Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance | Journal of Immunology | 2007 | 202 |
46 | PSMA-Based [18F]DCFPyL PET/CT Is Superior to Conventional Imaging for Lesion Detection in Patients with Metastatic Prostate Cancer | Molecular Imaging and Biology | 2016 | 202 |
47 | TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer | Cancer Discovery | 2016 | 196 |
48 | DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2 | Oncogene | 2015 | 195 |
49 | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer | Nature Communications | 2018 | 188 |
50 | Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade | | 2014 | 186 |