# | Title | Journal | Year | Citations |
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1 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
2 | RNA velocity of single cells | Nature | 2018 | 2,602 |
3 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
4 | An atlas of active enhancers across human cell types and tissues | Nature | 2014 | 2,269 |
5 | Estrogen Receptors: How Do They Signal and What Are Their Targets | Physiological Reviews | 2007 | 1,489 |
6 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
7 | The Norway spruce genome sequence and conifer genome evolution | Nature | 2013 | 1,303 |
8 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,201 |
9 | Accelerometer Data Collection and Processing Criteria to Assess Physical Activity and Other Outcomes: A Systematic Review and Practical Considerations | Sports Medicine | 2017 | 1,126 |
10 | DNA-Binding Specificities of Human Transcription Factors | Cell | 2013 | 1,085 |
11 | Quantitative single-cell RNA-seq with unique molecular identifiers | Nature Methods | 2014 | 1,047 |
12 | Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis | Nature Biotechnology | 2013 | 874 |
13 | Counting absolute numbers of molecules using unique molecular identifiers | Nature Methods | 2012 | 869 |
14 | Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility | PLoS ONE | 2012 | 860 |
15 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
16 | Lgr5 marks cycling, yet long-lived, hair follicle stem cells | Nature Genetics | 2008 | 846 |
17 | Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 726 |
18 | DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis | American Journal of Human Genetics | 2016 | 717 |
19 | Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease | Nature Genetics | 2011 | 698 |
20 | Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 685 |
21 | Autophagy in major human diseases | EMBO Journal | 2021 | 615 |
22 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus | Nature Genetics | 2007 | 590 |
23 | Genome-wide association identifies multiple ulcerative colitis susceptibility loci | Nature Genetics | 2010 | 572 |
24 | MED12 , the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas | Science | 2011 | 547 |
25 | Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis | Nature Genetics | 2015 | 529 |
26 | PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain | Cancer Cell | 2009 | 508 |
27 | International Union of Pharmacology. LXIV. Estrogen Receptors | Pharmacological Reviews | 2006 | 492 |
28 | The Descriptive Epidemiology of Sitting | American Journal of Preventive Medicine | 2011 | 477 |
29 | Optimization of the CHARMM Additive Force Field for DNA: Improved Treatment of the BI/BII Conformational Equilibrium | Journal of Chemical Theory and Computation | 2012 | 464 |
30 | DNA-dependent formation of transcription factor pairs alters their binding specificity | Nature | 2015 | 462 |
31 | Transgenerational response to nutrition, early life circumstances and longevity | European Journal of Human Genetics | 2007 | 459 |
32 | Comparative Functional Genomics of the Fission Yeasts | Science | 2011 | 458 |
33 | Spatial organization of the somatosensory cortex revealed by osmFISH | Nature Methods | 2018 | 402 |
34 | Interplay Between Weight Loss and Gut Microbiota Composition in Overweight Adolescents | Obesity | 2009 | 392 |
35 | TT-seq maps the human transient transcriptome | Science | 2016 | 384 |
36 | CTCF/cohesin-binding sites are frequently mutated in cancer | Nature Genetics | 2015 | 383 |
37 | Estrogen receptor alpha and beta in health and disease | Best Practice and Research in Clinical Endocrinology and Metabolism | 2015 | 378 |
38 | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Science Immunology | 2021 | 357 |
39 | BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis | Cell | 2019 | 352 |
40 | Liver X receptor in cholesterol metabolism | Journal of Endocrinology | 2010 | 351 |
41 | Comparisons of leisure-time physical activity and cardiorespiratory fitness as predictors of all-cause mortality in men and women | British Journal of Sports Medicine | 2011 | 343 |
42 | PPARα is a key regulator of hepatic FGF21 | Biochemical and Biophysical Research Communications | 2007 | 337 |
43 | Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease | Journal of Cystic Fibrosis | 2011 | 332 |
44 | Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites | Cell | 2013 | 327 |
45 | Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations | Journal of Chemical Theory and Computation | 2012 | 325 |
46 | Physical Activity and Inactivity in an Adult Population Assessed by Accelerometry | Medicine and Science in Sports and Exercise | 2007 | 324 |
47 | The role of enhancers in cancer | Nature Reviews Cancer | 2016 | 320 |
48 | Conservation of transcription factor binding specificities across 600 million years of bilateria evolution | ELife | 2015 | 316 |
49 | Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis | Nature Genetics | 2012 | 311 |
50 | Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype | Journal of Experimental Medicine | 2012 | 292 |