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Top Articles

#TitleJournalYearCitations
1Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaNature20122,129
2Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosomeNature Cell Biology20001,358
3Electrochemical Biosensing Platforms Using Platinum Nanoparticles and Carbon NanotubesAnalytical Chemistry20041,017
4The human CD46 molecule is a receptor for measles virus (Edmonston strain)Cell19931,010
5Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced ApoptosisMolecular and Cellular Biology1997879
6Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosisProceedings of the National Academy of Sciences of the United States of America2007611
7Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidumNature1991552
8A family of yeast expression vectors containing the phage f1 intergenic region1Gene1987536
9Bacillus thuringiensisCrylA(a) Insecticidal Toxin: Crystal Structure and Channel FormationJournal of Molecular Biology1995516
10Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteinsProtein Science1993506
11Biochemical methane potential (BMP) of solid organic substrates: evaluation of anaerobic biodegradability using data from an international interlaboratory studyJournal of Chemical Technology and Biotechnology2011411
12Characteristics and Properties of Carboxylated Cellulose Nanocrystals Prepared from a Novel One‐Step ProcedureSmall2011403
13Advances in carbon nanotube based electrochemical sensors for bioanalytical applicationsBiotechnology Advances2011401
14Insights into interfacial activation from an open structure of Candida rugosa lipaseJournal of Biological Chemistry1993388
15Applications of functionalized and nanoparticle-modified nanocrystalline celluloseTrends in Biotechnology2012366
16Baeyer−Villiger Monooxygenases: More Than Just Green ChemistryChemical Reviews2011361
17Biosensor technology: Technology push versus market pullBiotechnology Advances2008359
18Solvated Interaction Energy (SIE) for Scoring Protein−Ligand Binding Affinities. 1. Exploring the Parameter SpaceJournal of Chemical Information and Modeling2007358
19Layered structure of bacterial aggregates produced in an upflow anaerobic sludge bed and filter reactorApplied and Environmental Microbiology1990353
20Soil characteristics more strongly influence soil bacterial communities than land-use typeFEMS Microbiology Ecology2012347
21Two conformational states of Candida rugosa lipaseProtein Science1994346
22Transcription Profiling ofCandida albicansCells Undergoing the Yeast-to-Hyphal TransitionMolecular Biology of the Cell2002346
23Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.EMBO Journal1996345
24Selection of Specific Endophytic Bacterial Genotypes by Plants in Response to Soil ContaminationApplied and Environmental Microbiology2001338
25The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating EnzymeJournal of Virology2005323
26Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicansProceedings of the National Academy of Sciences of the United States of America1996315
27Enhanced secretion from insect cells of a foreign protein fused to the honeybee melittin signal peptideGene1991296
28Microbial degradation of explosives: biotransformation versus mineralizationApplied Microbiology and Biotechnology2000295
29A Human-Curated Annotation of the Candida albicans GenomePLoS Genetics2005293
30MANF: A New Mesencephalic, Astrocyte-Derived Neurotrophic Factor with Selectivity for Dopaminergic NeuronsJournal of Molecular Neuroscience2003289
31Biofilm Matrix Regulation by Candida albicans Zap1PLoS Biology2009286
32The functional potential of high Arctic permafrost revealed by metagenomic sequencing, qPCR and microarray analysesISME Journal2010273
33Structural proteomics of an archaeonNature Structural Biology2000272
34Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragmentScience1991270
35Microbial contamination of embryos and semen during long term banking in liquid nitrogenCryobiology2003270
36Analogs of Reaction Intermediates Identify a Unique Substrate Binding Site in Candida rugosa LipaseBiochemistry1994262
37Generalization of monod kinetics for analysis of growth data with substrate inhibitionBiotechnology and Bioengineering1987261
38Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the beta-galactosidase geneJournal of Virology1990258
39Recent developments in transferred NOE methodsProgress in Nuclear Magnetic Resonance Spectroscopy1994256
40Metallic Nanoparticle−Carbon Nanotube Composites for Electrochemical Determination of Explosive Nitroaromatic CompoundsAnalytical Chemistry2006256
41Role of the Occluding Loop in Cathepsin B ActivityJournal of Biological Chemistry1997241
42Liquid-to-Gas Mass Transfer in Anaerobic Processes: Inevitable Transfer Limitations of Methane and Hydrogen in the Biomethanation ProcessApplied and Environmental Microbiology1990239
43Plasma membrane domain organization regulates EGFR signaling in tumor cellsJournal of Cell Biology2007231
44Electrochemical Determination of Arsenite Using a Gold Nanoparticle Modified Glassy Carbon Electrode and Flow AnalysisAnalytical Chemistry2006229
45[33] Catalytic mechanism in papain family of cysteine peptidasesMethods in Enzymology1994228
46[4] Lipases and hydrolase foldMethods in Enzymology1997224
47Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicansPLoS Pathogens2009223
48Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and ActinScience1995218
49Gene Cloning and Characterization of Multiple Alkane Hydroxylase Systems in Rhodococcus Strains Q15 and NRRL B-16531Applied and Environmental Microbiology2002213
50A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.Proceedings of the National Academy of Sciences of the United States of America1993207