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Top Articles

#TitleJournalYearCitations
1Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology20036,653
2Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018Cell Death and Differentiation20184,036
3A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Nature Immunology20053,869
4The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Nature20013,186
5Toll-like receptors in the induction of the innate immune responseNature20002,784
6T cell receptor antagonist peptides induce positive selectionCell19942,538
7MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGESAnnual Review of Immunology19992,366
8Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3Immunity20052,070
9The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptorsProceedings of the National Academy of Sciences of the United States of America20001,823
10TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt functionNature20081,649
11A function for interleukin 2 in Foxp3-expressing regulatory T cellsNature Immunology20051,577
12Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceNature Immunology20071,523
13Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2Journal of Experimental Medicine20031,447
14Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitusNature Genetics20001,403
15Regulation of Interferon‐γ During Innate and Adaptive Immune ResponsesAdvances in Immunology20071,373
16The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogensNature19991,295
17Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in VivoJournal of Experimental Medicine20001,171
18A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and SurvivalImmunity20011,124
19Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell HelpScience20031,107
20Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like diseaseNature Medicine20161,088
21Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteriaNature Immunology20101,074
22FOXP3 Controls Regulatory T Cell Function through Cooperation with NFATCell20061,019
23Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateNature20101,009
24Foxp3-dependent programme of regulatory T-cell differentiationNature20071,008
25TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsJournal of Experimental Medicine2005918
26CD4 + Regulatory T Cells Control T H 17 Responses in a Stat3-Dependent MannerScience2009895
27Autoimmune T cell responses in the central nervous systemNature Reviews Immunology2009849
28A mechanism for the initiation of allergen-induced T helper type 2 responsesNature Immunology2008837
29Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infectionJournal of Experimental Medicine2005813
30Essential versus accessory aspects of cell death: recommendations of the NCCD 2015Cell Death and Differentiation2015811
31Effector and Memory CTL DifferentiationAnnual Review of Immunology2007776
32CD8+ T Cells: Foot Soldiers of the Immune SystemImmunity2011775
33Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cellsNature2007765
34Selecting and maintaining a diverse T-cell repertoireNature1999747
35Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus InfectionImmunity1998741
36Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3Nature Immunology2007741
37Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophagesProceedings of the National Academy of Sciences of the United States of America1999724
38Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 ProteinImmunity2009716
39Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentProceedings of the National Academy of Sciences of the United States of America2006698
40Regulation of inflammatory responses by IL-17FJournal of Experimental Medicine2008690
41Necroptosis in development, inflammation and diseaseNature Reviews Molecular Cell Biology2017687
42Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasomeProceedings of the National Academy of Sciences of the United States of America2010680
43Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cellsNature2006678
44Helping the CD8+ T-cell responseNature Reviews Immunology2004673
45Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanismNature Immunology2001637
46Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell ReceptorsImmunity2004634
47Foxp3 in control of the regulatory T cell lineageNature Immunology2007619
48Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseNature Genetics2009610
49Epigenetic control of T-helper-cell differentiationNature Reviews Immunology2009600
50Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven ProliferationJournal of Experimental Medicine2000591