| # | Title | Journal | Year | Citations |
|---|
| 1 | Base-Calling of Automated Sequencer Traces UsingPhred. I. Accuracy Assessment | Genome Research | 1998 | 5,939 |
| 2 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database | Journal of the American Society for Mass Spectrometry | 1994 | 5,912 |
| 3 | Base-Calling of Automated Sequencer Traces Using Phred. II. Error Probabilities | Genome Research | 1998 | 4,991 |
| 4 | Quantitative analysis of complex protein mixtures using isotope-coded affinity tags | Nature Biotechnology | 1999 | 4,673 |
| 5 | Molecular characterization of mitochondrial apoptosis-inducing factor | Nature | 1999 | 3,697 |
| 6 | Correlation between Protein and mRNA Abundance in Yeast | Molecular and Cellular Biology | 1999 | 3,521 |
| 7 | Consed: A Graphical Tool for Sequence Finishing | Genome Research | 1998 | 3,116 |
| 8 | Base-calling of automated sequencer traces using phred. II. Error probabilities | Genome Research | 1998 | 2,632 |
| 9 | Direct analysis of protein complexes using mass spectrometry | Nature Biotechnology | 1999 | 2,201 |
| 10 | DTASelect and Contrast: Tools for Assembling and Comparing Protein Identifications from Shotgun Proteomics | Journal of Proteome Research | 2002 | 1,327 |
| 11 | Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,250 |
| 12 | Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database | Analytical Chemistry | 1995 | 1,219 |
| 13 | Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 | Nature Genetics | 1997 | 1,184 |
| 14 | The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response | Cell | 1998 | 1,138 |
| 15 | PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing | Nucleic Acids Research | 1997 | 858 |
| 16 | Variation is the spice of life | Nature Genetics | 2001 | 832 |
| 17 | A systematic approach to the analysis of protein phosphorylation | Nature Biotechnology | 2001 | 742 |
| 18 | Peptide Mass Maps: A Highly Informative Approach to Protein Identification | Analytical Biochemistry | 1993 | 678 |
| 19 | Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway | Immunity | 1997 | 656 |
| 20 | CD91: a receptor for heat shock protein gp96 | Nature Immunology | 2000 | 646 |
| 21 | Mass spectrometry and the age of the proteome | Journal of Mass Spectrometry | 1998 | 643 |
| 22 | The origin of interspersed repeats in the human genome | Current Opinion in Genetics and Development | 1996 | 572 |
| 23 | Direct Analysis and Identification of Proteins in Mixtures by LC/MS/MS and Database Searching at the Low-Femtomole Level | Analytical Chemistry | 1997 | 500 |
| 24 | DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene | Nature Genetics | 1998 | 483 |
| 25 | Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel | Journal of Molecular Biology | 1999 | 479 |
| 26 | Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome | Nucleic Acids Research | 1998 | 463 |
| 27 | Sequence variation in the human angiotensin converting enzyme | Nature Genetics | 1999 | 452 |
| 28 | The Complete 685-Kilobase DNA Sequence of the Human beta T Cell Receptor Locus | Science | 1996 | 429 |
| 29 | Mass spectrometric approaches for the identification of gel-separated proteins | Electrophoresis | 1995 | 415 |
| 30 | Mining Genomes: Correlating Tandem Mass Spectra of Modified and Unmodified Peptides to Sequences in Nucleotide Databases | Analytical Chemistry | 1995 | 384 |
| 31 | Protein Identification at the Low Femtomole Level from Silver-Stained Gels Using a New Fritless Electrospray Interface for Liquid Chromatography–Microspray and Nanospray Mass Spectrometry | Analytical Biochemistry | 1998 | 380 |
| 32 | Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism | American Journal of Human Genetics | 2000 | 377 |
| 33 | Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2 | Cancer Research | 1999 | 375 |
| 34 | Mass spectrometry | Trends in Genetics | 2000 | 346 |
| 35 | Comparative hybridization of an array of 21 500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas | Gene | 1999 | 342 |
| 36 | A new strategy for genome sequencing | Nature | 1996 | 338 |
| 37 | Analysis of expressed sequence tags indicates 35,000 human genes | Nature Genetics | 2000 | 336 |
| 38 | Automated Finishing with Autofinish | Genome Research | 2001 | 336 |
| 39 | Integration of cytogenetic landmarks into the draft sequence of the human genome | Nature | 2001 | 302 |
| 40 | High throughput protein characterization by automated reverse‐phase chromatography/electrospray tandem mass spectrometry | Protein Science | 1998 | 297 |
| 41 | Evidence for a Rare Prostate Cancer–Susceptibility Locus at Chromosome 1p36 | American Journal of Human Genetics | 1999 | 292 |
| 42 | Testing for Differentially-Expressed Genes by Maximum-Likelihood Analysis of Microarray Data | Journal of Computational Biology | 2000 | 286 |
| 43 | Cloning and Characterization of a Novel Insulin-regulated Membrane Aminopeptidase from Glut4 Vesicles | Journal of Biological Chemistry | 1995 | 285 |
| 44 | TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion | EMBO Journal | 1998 | 278 |
| 45 | Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray | Gene | 1999 | 277 |
| 46 | Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus. | Journal of Cell Biology | 1995 | 275 |
| 47 | From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 268 |
| 48 | High-density oligonucleotide arrays | Biosensors and Bioelectronics | 1996 | 267 |
| 49 | A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients | Nature Genetics | 1998 | 262 |
| 50 | The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1 | Immunity | 1998 | 261 |
