| # | Title | Journal | Year | Citations |
|---|
| 1 | Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Nature Medicine | 1996 | 2,545 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 3 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 4 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 5 | Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly People | Stroke | 1996 | 1,191 |
| 6 | Pathways to neuronal injury and apoptosis in HIV-associated dementia | Nature | 2001 | 1,169 |
| 7 | A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse | British Journal of Cancer | 2000 | 1,154 |
| 8 | Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy | Nature Neuroscience | 2006 | 985 |
| 9 | Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells | Cancer Discovery | 2017 | 945 |
| 10 | Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells | Nature Cell Biology | 2007 | 899 |
| 11 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 12 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 13 | Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype | American Journal of Human Genetics | 2002 | 611 |
| 14 | Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies | BMJ: British Medical Journal | 2005 | 564 |
| 15 | Thrombolysis for acute ischaemic stroke | The Cochrane Library | 2016 | 564 |
| 16 | A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease | Journal of Experimental Medicine | 2008 | 559 |
| 17 | TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy | Neuron | 2016 | 528 |
| 18 | Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest | JAMA - Journal of the American Medical Association | 2014 | 502 |
| 19 | Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review | Journal of Neurosurgery | 2015 | 500 |
| 20 | Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life | Diabetes Research and Clinical Practice | 2000 | 497 |
| 21 | Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database | PLoS Genetics | 2012 | 495 |
| 22 | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function | Nature Communications | 2018 | 484 |
| 23 | Lacunar Infarcts Defined by Magnetic Resonance Imaging of 3660 Elderly People: The Cardiovascular Health Study | Archives of Neurology | 1998 | 474 |
| 24 | Narcolepsy is strongly associated with the T-cell receptor alpha locus | Nature Genetics | 2009 | 445 |
| 25 | Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies | Lancet Neurology, The | 2012 | 445 |
| 26 | Incidence, Manifestations, and Predictors of Worsening White Matter on Serial Cranial Magnetic Resonance Imaging in the Elderly | Stroke | 2005 | 436 |
| 27 | Implications of Extubation Delay in Brain-Injured Patients Meeting Standard Weaning Criteria | American Journal of Respiratory and Critical Care Medicine | 2000 | 419 |
| 28 | Immune surveillance in multiple sclerosis patients treated with natalizumab | Annals of Neurology | 2006 | 414 |
| 29 | Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society | Genetics in Medicine | 2015 | 414 |
| 30 | Methotrexate-Immobilized Poly(ethylene glycol) Magnetic Nanoparticles for MR Imaging and Drug Delivery | Small | 2006 | 395 |
| 31 | The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors | Nature Neuroscience | 2010 | 395 |
| 32 | Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene | PLoS Genetics | 2010 | 394 |
| 33 | Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2 | Annals of Neurology | 2006 | 380 |
| 34 | First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma | Journal of Translational Medicine | 2018 | 376 |
| 35 | Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14 | Nature Medicine | 2011 | 348 |
| 36 | Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals | Neuron | 2004 | 337 |
| 37 | Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report | Blood | 2010 | 325 |
| 38 | Are "Generalized" Seizures Truly Generalized? Evidence of Localized Mesial Frontal and Frontopolar Discharges in Absence | Epilepsia | 2004 | 307 |
| 39 | Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop | Journal of Neuroscience | 2000 | 304 |
| 40 | The AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke randomized trial: Rationale and methods | International Journal of Stroke | 2019 | 304 |
| 41 | Recovery recapitulates ontogeny | Trends in Neurosciences | 2000 | 301 |
| 42 | Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy | Nature Communications | 2017 | 298 |
| 43 | Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors | Genetics in Medicine | 2011 | 297 |
| 44 | New roles for astrocytes (stars at last) | Trends in Neurosciences | 2003 | 296 |
| 45 | rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice | Nature Medicine | 2006 | 274 |
| 46 | Progression to dementia in patients with isolated memory loss | Lancet, The | 1997 | 268 |
| 47 | Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroups | Neurology | 2004 | 267 |
| 48 | Specific deletion of Na V 1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 266 |
| 49 | Incidence, Manifestations, and Predictors of Brain Infarcts Defined by Serial Cranial Magnetic Resonance Imaging in the Elderly | Stroke | 2002 | 264 |
| 50 | Burden of Neurological Disorders Across the US From 1990-2017 | JAMA Neurology | 2021 | 262 |
