| # | Title | Journal | Year | Citations |
|---|
| 1 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 4 | The protein Id: A negative regulator of helix-loop-helix DNA binding proteins | Cell | 1990 | 2,214 |
| 5 | Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts | Nature | 2004 | 2,050 |
| 6 | Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts | Nature Biotechnology | 2007 | 2,050 |
| 7 | The Pathogenesis of Atherosclerosis | New England Journal of Medicine | 1976 | 2,045 |
| 8 | The biology of platelet-derived growth factor | Cell | 1986 | 2,010 |
| 9 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 10 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 11 | Positional Cloning of the Werner's Syndrome Gene | Science | 1996 | 1,675 |
| 12 | A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro | Proceedings of the National Academy of Sciences of the United States of America | 1974 | 1,670 |
| 13 | Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature | Journal of Neuropathology and Experimental Neurology | 2012 | 1,599 |
| 14 | THE SMOOTH MUSCLE CELL | Journal of Cell Biology | 1971 | 1,598 |
| 15 | Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria | Science | 2005 | 1,576 |
| 16 | Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron | Nature | 2004 | 1,540 |
| 17 | ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. | Arteriosclerosis and Thrombosis: A Journal of Vascular Biology | 1994 | 1,445 |
| 18 | A comparative encyclopedia of DNA elements in the mouse genome | Nature | 2014 | 1,444 |
| 19 | mTOR is a key modulator of ageing and age-related disease | Nature | 2013 | 1,390 |
| 20 | The Pathogenesis of Atherosclerosis | New England Journal of Medicine | 1976 | 1,281 |
| 21 | Clinical and Genetic Features of Ehlers–Danlos Syndrome Type IV, the Vascular Type | New England Journal of Medicine | 2000 | 1,219 |
| 22 | Conserved cell types with divergent features in human versus mouse cortex | Nature | 2019 | 1,198 |
| 23 | Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts | Nature | 2014 | 1,194 |
| 24 | Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex | Journal of Neuroscience | 2005 | 1,156 |
| 25 | Metformin improves healthspan and lifespan in mice | Nature Communications | 2013 | 1,118 |
| 26 | Heart regeneration | Nature | 2011 | 1,112 |
| 27 | Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease | FASEB Journal | 2005 | 1,065 |
| 28 | Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span | Cell Metabolism | 2008 | 1,060 |
| 29 | Primary age-related tauopathy (PART): a common pathology associated with human aging | Acta Neuropathologica | 2014 | 1,060 |
| 30 | Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF | Science | 1991 | 1,048 |
| 31 | Mutator phenotype may be required for multistage carcinogenesis | Cancer Research | 1991 | 976 |
| 32 | Endothelial Activation and Blood–Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells | Cancer Discovery | 2017 | 945 |
| 33 | Cell Biology of Atherosclerosis | Annual Review of Physiology | 1995 | 927 |
| 34 | Regenerating the heart | Nature Biotechnology | 2005 | 906 |
| 35 | Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14 | Science | 1992 | 904 |
| 36 | Sequence-specific DNA binding by the c-Myc protein | Science | 1990 | 901 |
| 37 | Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 898 |
| 38 | Fidelity of HIV-1 reverse transcriptase | Science | 1988 | 862 |
| 39 | A method for staining epoxy sections for light microscopy | Journal of Ultrastructure Research | 1961 | 829 |
| 40 | Cardiomyocyte Grafting for Cardiac Repair: Graft Cell Death and Anti-Death Strategies | Journal of Molecular and Cellular Cardiology | 2001 | 823 |
| 41 | Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture | Cell Stem Cell | 2011 | 819 |
| 42 | The molecular basis of the human serum paraoxonase activity polymorphism | Nature Genetics | 1993 | 789 |
| 43 | Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes | Nature Methods | 2013 | 784 |
| 44 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 45 | CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome | Science | 1993 | 776 |
| 46 | A Review of its Symptomatology, Natural History, Pathologic Features, Genetics And Relationship to the Natural Aging Process | Medicine (United States) | 1966 | 762 |
| 47 | Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions | Periodontology 2000 | 1997 | 758 |
| 48 | The Intima | Circulation Research | 1995 | 755 |
| 49 | TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop | Cell | 1990 | 746 |
| 50 | NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice | Journal of Hepatology | 2017 | 738 |
