| # | Title | Journal | Year | Citations |
|---|
| 1 | From local explanations to global understanding with explainable AI for trees | Nature Machine Intelligence | 2020 | 2,869 |
| 2 | Prospective Study of Asymptomatic Valvular Aortic Stenosis | Circulation | 1997 | 920 |
| 3 | A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome | Cell Reports | 2016 | 745 |
| 4 | Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor | Nature | 1995 | 710 |
| 5 | Complication Rates Associated With Pacemaker or Implantable Cardioverter-Defibrillator Generator Replacements and Upgrade Procedures | Circulation | 2010 | 658 |
| 6 | Exercise stress testing in evaluation of patients with ischemic heart disease | Progress in Cardiovascular Diseases | 1969 | 651 |
| 7 | The Global Burden of Cardiovascular Diseases and Risk Factors | Journal of the American College of Cardiology | 2019 | 595 |
| 8 | National Trends in Ambulatory Oral Anticoagulant Use | American Journal of Medicine | 2015 | 513 |
| 9 | Valvular Aortic Stenosis | Journal of the American College of Cardiology | 2006 | 504 |
| 10 | Electrocardiographic interpretation in athletes: the ‘Seattle Criteria’: Table 1 | British Journal of Sports Medicine | 2013 | 459 |
| 11 | Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials | Lancet Diabetes and Endocrinology,the | 2021 | 437 |
| 12 | Genome-wide association study of PR interval | Nature Genetics | 2010 | 400 |
| 13 | Pathogenesis of Calcific Aortic Valve Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 2006 | 365 |
| 14 | Effect of Chronic Total Coronary Occlusion on Treatment Strategy | American Journal of Cardiology | 2005 | 357 |
| 15 | The Global Burden of Disease Study and the Preventable Burden of NCD | Global Heart | 2016 | 343 |
| 16 | Osteopontin Is Expressed in Human Aortic Valvular Lesions | Circulation | 1995 | 341 |
| 17 | Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes | New England Journal of Medicine | 2021 | 339 |
| 18 | International Recommendations for Electrocardiographic Interpretation in Athletes | Journal of the American College of Cardiology | 2017 | 318 |
| 19 | Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction | Nature Genetics | 2010 | 308 |
| 20 | Factors influencing survival after out-of-hospital cardiac arrest | Journal of the American College of Cardiology | 1986 | 302 |
| 21 | Free Fatty Acid Impairment of Nitric Oxide Production in Endothelial Cells Is Mediated by IKKβ | Arteriosclerosis, Thrombosis, and Vascular Biology | 2005 | 298 |
| 22 | Nephropathy requiring dialysis after percutaneous coronary intervention and the critical role of an adjusted contrast dose | American Journal of Cardiology | 2002 | 297 |
| 23 | International criteria for electrocardiographic interpretation in athletes: Consensus statement | British Journal of Sports Medicine | 2017 | 291 |
| 24 | Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest | Resuscitation | 2016 | 285 |
| 25 | The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques | Nature Immunology | 2012 | 280 |
| 26 | Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles | American Journal of Physiology - Heart and Circulatory Physiology | 2001 | 279 |
| 27 | Hospital outcomes in patients presenting with congestive heart failure complicating acute myocardial infarction | Journal of the American College of Cardiology | 2002 | 276 |
| 28 | Inflammation in Carotid Atherosclerotic Plaque: A Dynamic Contrast-enhanced MR Imaging Study | Radiology | 2006 | 275 |
| 29 | Association of Angiotensin-Converting Enzyme With Low-Density Lipoprotein in Aortic Valvular Lesions and in Human Plasma | Circulation | 2002 | 271 |
| 30 | Transcatheter Aortic Valve Implantation Within Degenerated Aortic Surgical Bioprostheses | Journal of the American College of Cardiology | 2017 | 271 |
| 31 | A multiple active contour model for cardiac boundary detection on echocardiographic sequences | IEEE Transactions on Medical Imaging | 1996 | 270 |
| 32 | Chest Compression Rates and Survival Following Out-of-Hospital Cardiac Arrest* | Critical Care Medicine | 2015 | 270 |
| 33 | N-Terminal Pro-B-Type Natriuretic Peptide Is a Major Predictor of the Development of Atrial Fibrillation | Circulation | 2009 | 269 |
| 34 | Effects of Prolonged Intensive Lipid-Lowering Therapy on the Characteristics of Carotid Atherosclerotic Plaques In Vivo by MRI | Arteriosclerosis, Thrombosis, and Vascular Biology | 2001 | 266 |
| 35 | HMG CoA reductase inhibitor (statin) and aortic valve calcium | Lancet, The | 2002 | 255 |
| 36 | Comparison of presentation, treatment, and outcome of acute myocardial infarction in men versus women (the Myocardial Infarction Triage and Intervention Registry) | American Journal of Cardiology | 1996 | 252 |
| 37 | Myocardial infarction triage and intervention project—Phase I: Patient characteristics and feasibility of prehospital initiation of thrombolytic therapy | Journal of the American College of Cardiology | 1990 | 248 |
| 38 | A Quantitative Proteome Map of the Human Body | Cell | 2020 | 243 |
| 39 | International recommendations for electrocardiographic interpretation in athletes | European Heart Journal | 2018 | 237 |
| 40 | Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium | Biomaterials | 2011 | 235 |
| 41 | Pregnancy in women with valvular heart disease | Heart | 2007 | 227 |
| 42 | A prospective randomized evaluation of biphasic versus monophasic waveform pulses on defibrillation efficacy in humans | Journal of the American College of Cardiology | 1989 | 224 |
| 43 | Cardiovascular Magnetic Resonance Imaging for Valvular Heart Disease | Circulation | 2009 | 222 |
| 44 | Toxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmias | Journal of the American College of Cardiology | 1983 | 218 |
| 45 | Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study | Clinical Pharmacology and Therapeutics | 2008 | 217 |
| 46 | European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections—endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio | Europace | 2020 | 216 |
| 47 | Hemodynamic progression of aortic stenosis in adults assessed by doppler echocardiography | Journal of the American College of Cardiology | 1989 | 213 |
| 48 | CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis | Journal of Clinical Investigation | 2018 | 209 |
| 49 | Comparison of Naive Sixth-Grade Children With Trained Professionals in the Use of an Automated External Defibrillator | Circulation | 1999 | 207 |
| 50 | Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells | Journal of Biological Chemistry | 1997 | 205 |
