# | Title | Journal | Year | Citations |
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1 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases | Journal of Clinical Epidemiology | 1992 | 9,277 |
2 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
3 | Central nervous system control of food intake | Nature | 2000 | 5,309 |
4 | Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee | Journal of Bone and Mineral Research | 1987 | 4,558 |
5 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
6 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
7 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
8 | Systematic Localization of Common Disease-Associated Variation in Regulatory DNA | Science | 2012 | 3,129 |
9 | From local explanations to global understanding with explainable AI for trees | Nature Machine Intelligence | 2020 | 2,869 |
10 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
11 | Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis | Nature Genetics | 2006 | 2,584 |
12 | Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease | Nature Medicine | 1996 | 2,545 |
13 | The accessible chromatin landscape of the human genome | Nature | 2012 | 2,434 |
14 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,284 |
15 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
16 | Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery | New England Journal of Medicine | 2002 | 2,089 |
17 | Central nervous system control of food intake and body weight | Nature | 2006 | 2,065 |
18 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee | Journal of Bone and Mineral Research | 2013 | 2,023 |
19 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
20 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
21 | Myeloperoxidase: friend and foe | Journal of Leukocyte Biology | 2005 | 1,833 |
22 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
23 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
24 | Clinical Factors Associated With Calcific Aortic Valve Disease fn1fn1This study was supported in part by Contracts NO1-HC85079 through HC-850086 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. | Journal of the American College of Cardiology | 1997 | 1,775 |
25 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes | Diabetologia | 2003 | 1,767 |
26 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,685 |
27 | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease | Nature Genetics | 2014 | 1,685 |
28 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
29 | Positional Cloning of the Werner's Syndrome Gene | Science | 1996 | 1,675 |
30 | A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro | Proceedings of the National Academy of Sciences of the United States of America | 1974 | 1,670 |
31 | Matrix metalloproteinases as modulators of inflammation and innate immunity | Nature Reviews Immunology | 2004 | 1,655 |
32 | Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia | Science | 2008 | 1,654 |
33 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,625 |
34 | A comparative encyclopedia of DNA elements in the mouse genome | Nature | 2014 | 1,444 |
35 | A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice | Cell | 1996 | 1,400 |
36 | Common genetic determinants of vitamin D insufficiency: a genome-wide association study | Lancet, The | 2010 | 1,385 |
37 | Pathways to Diabetic Limb Amputation: Basis for Prevention | Diabetes Care | 1990 | 1,365 |
38 | 2012 Infectious Diseases Society of America Clinical Practice Guideline for the Diagnosis and Treatment of Diabetic Foot Infectionsa | Clinical Infectious Diseases | 2012 | 1,348 |
39 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
40 | Identification of targets of leptin action in rat hypothalamus. | Journal of Clinical Investigation | 1996 | 1,322 |
41 | Epidemiology and Outcome of Mould Infections in Hematopoietic Stem Cell Transplant Recipients | Clinical Infectious Diseases | 2002 | 1,303 |
42 | Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer | Nature Genetics | 2012 | 1,300 |
43 | Refinement, scoring, and validation of the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey* | Critical Care Medicine | 2007 | 1,287 |
44 | Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex | Diabetologia | 2003 | 1,272 |
45 | A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity | Nature Genetics | 1998 | 1,262 |
46 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016 | JAMA Oncology | 2018 | 1,260 |
47 | Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism | New England Journal of Medicine | 2018 | 1,237 |
48 | Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future | Lancet, The | 2014 | 1,230 |
49 | Genome-wide association study of blood pressure and hypertension | Nature Genetics | 2009 | 1,224 |
50 | The Simons Genome Diversity Project: 300 genomes from 142 diverse populations | Nature | 2016 | 1,216 |