# | Title | Journal | Year | Citations |
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1 | THE MAMMALIAN UNFOLDED PROTEIN RESPONSE | Annual Review of Biochemistry | 2005 | 2,699 |
2 | TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Nature Cell Biology | 2002 | 2,667 |
3 | A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression | Nature | 2011 | 1,760 |
4 | Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling | Genes and Development | 2003 | 1,566 |
5 | ER stress and the unfolded protein response | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2005 | 1,498 |
6 | Visualization of Interactions among bZIP and Rel Family Proteins in Living Cells Using Bimolecular Fluorescence Complementation | Molecular Cell | 2002 | 1,395 |
7 | A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress | Science | 2005 | 1,277 |
8 | A trip to the ER: coping with stress | Trends in Cell Biology | 2004 | 1,258 |
9 | Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis | Molecular Cell | 2001 | 1,217 |
10 | Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival | Molecular and Cellular Biology | 2003 | 1,074 |
11 | Role of amino acid transport and countertransport in nutrition and metabolism. | Physiological Reviews | 1990 | 1,035 |
12 | Membrane proteins and proteomics: Un amour impossible? | Electrophoresis | 2000 | 914 |
13 | Guanylate cyclase and the ⋅NO/cGMP signaling pathway | Biochimica Et Biophysica Acta - Bioenergetics | 1999 | 859 |
14 | The endoplasmic reticulum and the unfolded protein response | Seminars in Cell and Developmental Biology | 2007 | 858 |
15 | ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation | Cell Death and Differentiation | 2007 | 822 |
16 | A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells | Genes and Development | 1998 | 798 |
17 | From acute ER stress to physiological roles of the Unfolded Protein Response | Cell Death and Differentiation | 2006 | 760 |
18 | Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response | Cell | 2006 | 720 |
19 | Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis | Nature Biotechnology | 2003 | 716 |
20 | Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins | PLoS Biology | 2006 | 694 |
21 | Chemical Biology of H2S Signaling through Persulfidation | Chemical Reviews | 2018 | 690 |
22 | Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression | Molecular and Cellular Biology | 2006 | 662 |
23 | The SET-domain protein superfamily: protein lysine methyltransferases | Genome Biology | 2005 | 661 |
24 | Redox Biochemistry of Hydrogen Sulfide | Journal of Biological Chemistry | 2010 | 648 |
25 | Development of Genetic Circuitry Exhibiting Toggle Switch or Oscillatory Behavior in Escherichia coli | Cell | 2003 | 643 |
26 | Endoplasmic Reticulum Chaperone Protein GRP78 Protects Cells from Apoptosis Induced by Topoisomerase Inhibitors | Journal of Biological Chemistry | 2003 | 639 |
27 | Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development | Cell | 2001 | 631 |
28 | Molecular mechanisms of copper uptake and distribution | Current Opinion in Chemical Biology | 2002 | 630 |
29 | Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95 | Science | 1996 | 625 |
30 | Tight Junctions and Cell Polarity | Annual Review of Cell and Developmental Biology | 2006 | 621 |
31 | Orchestrating the unfolded protein response in health and disease | Journal of Clinical Investigation | 2002 | 615 |
32 | The POT1–TPP1 telomere complex is a telomerase processivity factor | Nature | 2007 | 609 |
33 | Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells | Annual Review of Biophysics | 2008 | 604 |
34 | Antioxidants reduce endoplasmic reticulum stress and improve protein secretion | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 593 |
35 | Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes | Journal of Clinical Investigation | 2008 | 591 |
36 | ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress | Developmental Cell | 2007 | 588 |
37 | Components of a New Human Protein Kinase Signal Transduction Pathway | Journal of Biological Chemistry | 1995 | 579 |
38 | Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules | Journal of Cell Biology | 2001 | 556 |
39 | The unfolded protein response in nutrient sensing and differentiation | Nature Reviews Molecular Cell Biology | 2002 | 540 |
40 | Relative Contributions of Cystathionine β-Synthase and γ-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions | Journal of Biological Chemistry | 2009 | 527 |
41 | The unfolded protein response | Neurology | 2006 | 519 |
42 | Signaling the Unfolded Protein Response from the Endoplasmic Reticulum | Journal of Biological Chemistry | 2004 | 508 |
43 | UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators | Developmental Cell | 2008 | 507 |
44 | Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells | Nature Protocols | 2006 | 498 |
45 | Biochemical Characterization of the Human Copper Transporter Ctr1 | Journal of Biological Chemistry | 2002 | 495 |
46 | Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways | Nature Chemical Biology | 2015 | 483 |
47 | Selective fluorescent probes for live-cell monitoring of sulphide | Nature Communications | 2011 | 472 |
48 | Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development | Journal of Cell Biology | 2007 | 460 |
49 | Direct interaction of two polarity complexes implicated in epithelial tight junction assembly | Nature Cell Biology | 2003 | 456 |
50 | Protein Tyrosine Phosphatases | Annual Review of Biochemistry | 1993 | 453 |