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Top Articles

#TitleJournalYearCitations
1Pathogenesis of parkinson's disease: dopamine, vesicles and α-synucleinNature Reviews Neuroscience20021,070
2Cell replacement therapies for central nervous system disordersNature Neuroscience2000897
3Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in ratsActa Neuropathologica2014708
4Direct conversion of human fibroblasts to dopaminergic neuronsProceedings of the National Academy of Sciences of the United States of America2011695
5Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal SystemJournal of Neuroscience2002633
6TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicityProceedings of the National Academy of Sciences of the United States of America2013600
7Characterization of Behavioral and Neurodegenerative Changes Following Partial Lesions of the Nigrostriatal Dopamine System Induced by Intrastriatal 6-Hydroxydopamine in the RatExperimental Neurology1998576
8A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's diseaseJournal of Experimental Medicine2008559
9Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's DiseaseNeuron2002553
10Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat BrainJournal of Neuroscience1999542
11L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNAEuropean Journal of Neuroscience1998533
12Identification of Two Distinct Progenitor Populations in the Lateral Ganglionic Eminence: Implications for Striatal and Olfactory Bulb NeurogenesisJournal of Neuroscience2003475
13Prospects for new restorative and neuroprotective treatments in Parkinson's diseaseNature1999442
14Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal SystemJournal of Neuroscience2000386
15Nigrostriatal  -synucleinopathy induced by viral vector-mediated overexpression of human  -synuclein: A new primate model of Parkinson's diseaseProceedings of the National Academy of Sciences of the United States of America2003382
16l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal FunctionNeurobiology of Disease2002378
17Generation of induced neurons via direct conversion in vivoProceedings of the National Academy of Sciences of the United States of America2013376
18Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful TransplantationStem Cell Reports2014373
19Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s DiseaseCell Stem Cell2014373
20Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2Development (Cambridge)2000357
21Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current ApproachesCell Transplantation2000327
22Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.Brain Research2000323
23Congo red and protein aggregation in neurodegenerative diseasesBrain Research Reviews2007323
24Neural transplantation for the treatment of Parkinson's diseaseLancet Neurology, The2003322
25Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.Nature Medicine2001311
26Acceleration of α-Synuclein Aggregation by ExosomesJournal of Biological Chemistry2015305
27Effect of Mutant α-Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell LineJournal of Biological Chemistry2002297
28Research in motion: the enigma of Parkinson's disease pathology spreadNature Reviews Neuroscience2008296
29Mechanisms of neural plasticity following brain injuryCurrent Opinion in Neurobiology2006290
30Caspase inhibition reduces apoptosis and increases survival of nigral transplantsNature Medicine1999279
31Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial ActivationCell Reports2015268
32Localized striatal delivery of GDNF as a treatment for Parkinson diseaseNature Neuroscience2004262
33Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neuronsProceedings of the National Academy of Sciences of the United States of America2012250
34Cell transplantation in Parkinson's disease: how can we make it work?Trends in Neurosciences2005249
35Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6Molecular and Cellular Neurosciences2004246
36Cell-based therapies for Parkinson disease—past insights and future potentialNature Reviews Neurology2015242
37Studies on Neuroprotective and Regenerative Effects of GDNF in a Partial Lesion Model of Parkinson's DiseaseNeurobiology of Disease1997239
38Current trends in stroke rehabilitation. A review with focus on brain plasticityActa Neurologica Scandinavica2011228
39Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's diseaseHuman Molecular Genetics2002226
40Optogenetic control of epileptiform activityProceedings of the National Academy of Sciences of the United States of America2009225
41Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in miceActa Neuropathologica2013224
42Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesiaBrain2008223
43Neuronal Plasticity and Dendritic Spines: Effect of Environmental Enrichment on Intact and Postischemic Rat BrainJournal of Cerebral Blood Flow and Metabolism2002222
44Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neuronsNeurobiology of Disease2012222
45Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the RatJournal of Cerebral Blood Flow and Metabolism1999221
46α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine NeuronsScience Translational Medicine2012221
47Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricleEuropean Journal of Neuroscience1999219
48Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In VivoPLoS ONE2012218
49Alpha‐synuclein transfers from neurons to oligodendrocytesGlia2014215
50Identification of Dopaminergic Neurons of Nigral and Ventral Tegmental Area Subtypes in Grafts of Fetal Ventral Mesencephalon Based on Cell Morphology, Protein Expression, and Efferent ProjectionsJournal of Neuroscience2005212