| # | Title | Journal | Year | Citations |
|---|
| 1 | Metformin improves healthspan and lifespan in mice | Nature Communications | 2013 | 1,118 |
| 2 | The manganese and calcium ions of photosynthetic oxygen evolution | Biochimica Et Biophysica Acta - Bioenergetics | 1992 | 1,080 |
| 3 | Vitamin D deficiency inhibits pancreatic secretion of insulin | Science | 1980 | 656 |
| 4 | Structure of the GDP domain of EF-Tu and location of the amino acids homologous to ras oncogene proteins | Science | 1985 | 652 |
| 5 | Interventions to Slow Aging in Humans: Are We Ready? | Aging Cell | 2015 | 481 |
| 6 | New domain motif: the structure of pectate lyase C, a secreted plant virulence factor | Science | 1993 | 452 |
| 7 | 1,25(OH) 2 ‐Vitamin D 3 receptors: gene regulation and genetic circuitry | FASEB Journal | 1988 | 446 |
| 8 | Refined Structure of an Intact IgG2a Monoclonal Antibody†,‡ | Biochemistry | 1997 | 435 |
| 9 | Lanosterol reverses protein aggregation in cataracts | Nature | 2015 | 351 |
| 10 | Current approaches to macromolecular crystallization | FEBS Journal | 1990 | 313 |
| 11 | The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro | Molecular Endocrinology | 2004 | 311 |
| 12 | Identification of a specific binding protein for 1 alpha,25-dihydroxyvitamin D3 in basal-lateral membranes of chick intestinal epithelium and relationship to transcaltachia. | Journal of Biological Chemistry | 1994 | 275 |
| 13 | Calcium Transport in Perfused Duodena from Normal Chicks: Enhancement within Fourteen Minutes of Exposure to 1,25-Dihydroxyvitamin D3* | Endocrinology | 1984 | 262 |
| 14 | Zinc–Ligand Interactions Modulate Assembly and Stability of the Insulin Hexamer – A Review | BioMetals | 2005 | 261 |
| 15 | Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability | Science | 1978 | 257 |
| 16 | Vitamin D3Improves Impaired Glucose Tolerance and Insulin Secretion in the Vitamin D-Deficient Ratin Vivo | Endocrinology | 1986 | 251 |
| 17 | γ-interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages | Biochemical and Biophysical Research Communications | 1985 | 238 |
| 18 | The three-dimensional structure of an intact monoclonal antibody for canine lymphoma | Nature | 1992 | 236 |
| 19 | Noncoding RNAs of Trithorax Response Elements Recruit Drosophila Ash1 to Ultrabithorax | Science | 2006 | 218 |
| 20 | Amino Acid Residues That Influence the Binding of Manganese or Calcium to Photosystem II. 1. The Lumenal Interhelical Domains of the D1 Polypeptide | Biochemistry | 1995 | 212 |
| 21 | Chemical structure of the lipopolysaccharide of Haemophilus influenzae strain I-69 Rd-/b+. Description of a novel deep-rough chemotype | FEBS Journal | 1988 | 209 |
| 22 | Interaction of Ammonia Monooxygenase from Nitrosomonas europaea with Alkanes, Alkenes, and Alkynes | Applied and Environmental Microbiology | 1988 | 205 |
| 23 | 5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction | BMC Genomics | 2013 | 204 |
| 24 | Role of D1-His190 in Proton-Coupled Electron Transfer Reactions in Photosystem II: A Chemical Complementation Study† | Biochemistry | 1998 | 197 |
| 25 | Loss-of-Function Mutations in the Ethylene ReceptorETR1 Cause Enhanced Sensitivity and Exaggerated Response to Ethylene in Arabidopsis | Plant Physiology | 2002 | 188 |
| 26 | Regulation of 1,25-Dihydroxyvitamin D3Production by Cultured Alveolar Macrophages from Normal Human Donors and from Patients with Pulmonary Sarcoidosis* | Journal of Clinical Endocrinology and Metabolism | 1987 | 186 |
| 27 | Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters. | Journal of Biological Chemistry | 1990 | 182 |
| 28 | Dual Regulation of c-Myc by p300 via Acetylation-Dependent Control of Myc Protein Turnover and Coactivation of Myc-Induced Transcription | Molecular and Cellular Biology | 2005 | 179 |
| 29 | Human ATAC Is a GCN5/PCAF-containing Acetylase Complex with a Novel NC2-like Histone Fold Module That Interacts with the TATA-binding Protein | Journal of Biological Chemistry | 2008 | 178 |
| 30 | Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms | PLoS Genetics | 2008 | 178 |
| 31 | FERONIA Is a Key Modulator of Brassinosteroid and Ethylene Responsiveness in Arabidopsis Hypocotyls | Molecular Plant | 2010 | 176 |
| 32 | Regulation of vitamin D metabolism | Best Practice and Research in Clinical Endocrinology and Metabolism | 2011 | 171 |
| 33 | Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3. | Journal of Biological Chemistry | 1993 | 171 |
| 34 | Refined Molecular Structure of Pig Pancreatic α-Amylase at 2·1 Å Resolution | Journal of Molecular Biology | 1994 | 166 |
| 35 | Unusual structural features in the parallel β-helix in pectate lyases | Structure | 1993 | 164 |
| 36 | Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite | PLoS ONE | 2008 | 160 |
| 37 | Normal tRNAs promote ribosomal frameshifting | Cell | 1979 | 158 |
| 38 | Tryptophan synthase: the workings of a channeling nanomachine | Trends in Biochemical Sciences | 2008 | 152 |
| 39 | Role of D1-His190 in the Proton-Coupled Oxidation of Tyrosine YZin Manganese-Depleted Photosystem II† | Biochemistry | 1999 | 150 |
| 40 | Site-Directed Photosystem II Mutants with Perturbed Oxygen-Evolving Properties. 1. Instability or Inefficient Assembly of the Manganese Cluster In vivo | Biochemistry | 1994 | 149 |
| 41 | Protein ligation of the photosynthetic oxygen-evolving center | Coordination Chemistry Reviews | 2008 | 149 |
| 42 | ATP synthase's second stalk comes into focus | Nature | 1998 | 148 |
| 43 | Screening and optimization strategies for macromolecular crystal growth | Acta Crystallographica Section D: Biological Crystallography | 1994 | 147 |
| 44 | Deep Sequencing of Serum Small RNAs Identifies Patterns of 5′ tRNA Half and YRNA Fragment Expression Associated with Breast Cancer | Biomarkers in Cancer | 2014 | 144 |
| 45 | Investigation of Virus Crystal Growth Mechanisms byIn SituAtomic Force Microscopy | Physical Review Letters | 1995 | 143 |
| 46 | Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction | Mechanisms of Ageing and Development | 2005 | 139 |
| 47 | The Rho-Rock-Myosin Signaling Axis Determines Cell-Cell Integrity of Self-Renewing Pluripotent Stem Cells | PLoS ONE | 2008 | 139 |
| 48 | Additive regulation of hepatic gene expression by dwarfism and caloric restriction | Physiological Genomics | 2004 | 136 |
| 49 | Amino Acid Residues That Influence the Binding of Manganese or Calcium to Photosystem II. 2. The Carboxy-Terminal Domain of the D1 Polypeptide | Biochemistry | 1995 | 132 |
| 50 | Phosphatidic acid binds to and inhibits the activity of Arabidopsis CTR1 | Journal of Experimental Botany | 2007 | 132 |
