| # | Title | Journal | Year | Citations |
|---|
| 1 | Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet Respiratory Medicine,the | 2015 | 937 |
| 2 | NASH limits anti-tumour surveillance in immunotherapy-treated HCC | Nature | 2021 | 649 |
| 3 | The Generation R Study: design and cohort update 2017 | European Journal of Epidemiology | 2016 | 608 |
| 4 | Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells | Endocrinology | 2004 | 521 |
| 5 | Islet Amyloid and Type 2 Diabetes Mellitus | New England Journal of Medicine | 2000 | 488 |
| 6 | An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis | Lancet Oncology, The | 2009 | 477 |
| 7 | Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection | Nature Medicine | 2000 | 384 |
| 8 | Islet β-cell secretion determines glucagon release from neighbouring α-cells | Nature Cell Biology | 2003 | 358 |
| 9 | Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours | European Journal of Nuclear Medicine and Molecular Imaging | 1997 | 348 |
| 10 | Ethnic Differences in Mortality, End-Stage Complications, and Quality of Care Among Diabetic Patients: A review | Diabetes Care | 2005 | 326 |
| 11 | Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study | Lancet Diabetes and Endocrinology,the | 2014 | 319 |
| 12 | Hydrogen Peroxide Alters Mitochondrial Activation and Insulin Secretion in Pancreatic Beta Cells | Journal of Biological Chemistry | 1999 | 300 |
| 13 | Caffeine Can Decrease Insulin Sensitivity in Humans | Diabetes Care | 2002 | 288 |
| 14 | Evaluation of a method to measure long term cortisol levels | Steroids | 2011 | 261 |
| 15 | Relative frequency and morphology of cancers in STK11 mutation carriers1 ☆ | Gastroenterology | 2004 | 228 |
| 16 | Long-Term Quality of Life of Patients With Head and Neck Cancer | Laryngoscope | 2000 | 227 |
| 17 | Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC–PGL syndromes: a clinicopathological and molecular analysis | European Journal of Endocrinology | 2014 | 219 |
| 18 | Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands | Journal of the National Cancer Institute | 2019 | 218 |
| 19 | Gait stability and variability measures show effects of impaired cognition and dual tasking in frail people | Journal of NeuroEngineering and Rehabilitation | 2011 | 207 |
| 20 | Differential Effect of Calcineurin Inhibitors, Anti-CD25 Antibodies and Rapamycin on the Induction of FOXP3 in Human T Cells | Transplantation | 2005 | 199 |
| 21 | A systematic review of the effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral arterial disease | Diabetes/Metabolism Research and Reviews | 2012 | 193 |
| 22 | A reliable and easily sectioned epoxy embedding medium | The Anatomical Record | 1964 | 191 |
| 23 | Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study | BMJ: British Medical Journal | 2018 | 190 |
| 24 | Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes | Diabetologia | 2007 | 186 |
| 25 | Leukocyte Activation by Triglyceride-Rich Lipoproteins | Arteriosclerosis, Thrombosis, and Vascular Biology | 2008 | 181 |
| 26 | Intestinal microbiome composition and its relation to joint pain and inflammation | Nature Communications | 2019 | 176 |
| 27 | Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer | European Journal of Cancer | 2001 | 174 |
| 28 | Metformin and lactic acidosis: cause or coincidence? A review of case reports | Journal of Internal Medicine | 2004 | 172 |
| 29 | Human Adipose Tissue-Derived Mesenchymal Stem Cells Abrogate Plasmablast Formation and Induce Regulatory B Cells Independently of T Helper Cells | Stem Cells | 2015 | 171 |
| 30 | Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia | JAMA Cardiology | 2020 | 169 |
| 31 | Relationship between gut microbiota and circulating metabolites in population-based cohorts | Nature Communications | 2019 | 168 |
| 32 | Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment – a systematic approach | Osteoarthritis and Cartilage | 2008 | 164 |
| 33 | Intra-patient variability in tacrolimus exposure: Causes, consequences for clinical management | Transplantation Reviews | 2015 | 161 |
| 34 | STRESS AND RHEUMATIC DISEASES | Rheumatic Disease Clinics of North America | 2000 | 154 |
| 35 | Clinical characteristics of type 1 diabetic patients with and without severe hypoglycemia | Diabetes Care | 2000 | 152 |
| 36 | Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: Long-term results of a randomized controlled trial | BMC Cancer | 2011 | 147 |
| 37 | Inhibition of Erythrocyte Cation Channels by Erythropoietin | Journal of the American Society of Nephrology: JASN | 2003 | 146 |
| 38 | Prevalence of Delayed Gastric Emptying in Diabetic Patients and Relationship to Dyspeptic Symptoms: A prospective study in unselected diabetic patients | Diabetes Care | 2003 | 139 |
| 39 | A National Guideline for Palliative Sedation in The Netherlands | Journal of Pain and Symptom Management | 2007 | 134 |
| 40 | Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo | European Journal of Clinical Investigation | 2002 | 129 |
| 41 | The content and amount of information given by medical oncologists when telling patients with advanced cancer what their treatment options are | European Journal of Cancer | 2004 | 128 |
| 42 | Staphylococcus aureusNasal Carriage Is Associated with Glucocorticoid Receptor Gene Polymorphisms | Journal of Infectious Diseases | 2006 | 122 |
| 43 | Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation | Stem Cell Reports | 2015 | 122 |
| 44 | Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity | JAMA Network Open | 2021 | 119 |
| 45 | Mitochondrial signals in glucose‐stimulated insulin secretion in the beta cell | Journal of Physiology | 2000 | 118 |
| 46 | A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models | BMC Musculoskeletal Disorders | 2008 | 117 |
| 47 | Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus | Lupus | 2006 | 116 |
| 48 | Mesenchymal Stromal Cells Anno 2019: Dawn of the Therapeutic Era? Concise Review | Stem Cells Translational Medicine | 2019 | 114 |
| 49 | Infectious complications and antibiotic use in renal transplant recipients during a 1-year follow-up | Clinical Microbiology and Infection | 2001 | 112 |
| 50 | Mitochondrial Metabolism Sets the Maximal Limit of Fuel-stimulated Insulin Secretion in a Model Pancreatic Beta Cell | Journal of Biological Chemistry | 2002 | 109 |
