| # | Title | Journal | Year | Citations |
|---|
| 1 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 2 | Signal integration in the endoplasmic reticulum unfolded protein response | Nature Reviews Molecular Cell Biology | 2007 | 5,491 |
| 3 | Global analysis of protein localization in budding yeast | Nature | 2003 | 3,884 |
| 4 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. SHORT COMMUNICATION | Journal of Microscopy | 2000 | 3,109 |
| 5 | A C. elegans mutant that lives twice as long as wild type | Nature | 1993 | 3,068 |
| 6 | Dynamic instability of microtubule growth | Nature | 1984 | 2,950 |
| 7 | Spatial partitioning of the regulatory landscape of the X-inactivation centre | Nature | 2012 | 2,595 |
| 8 | The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen | Cell | 1998 | 2,441 |
| 9 | The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions | Science | 2007 | 2,354 |
| 10 | Cyclin is degraded by the ubiquitin pathway | Nature | 1991 | 2,321 |
| 11 | Switching and Signaling at the Telomere | Cell | 2001 | 1,907 |
| 12 | CRISPR–Cas12-based detection of SARS-CoV-2 | Nature Biotechnology | 2020 | 1,884 |
| 13 | A cellular gene encodes scrapie PrP 27-30 protein | Cell | 1985 | 1,490 |
| 14 | Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy | Nature Medicine | 2011 | 1,460 |
| 15 | Transcription factor interactions: selectors of positive or negative regulation from a single DNA element | Science | 1990 | 1,332 |
| 16 | Cyclin synthesis drives the early embryonic cell cycle | Nature | 1989 | 1,236 |
| 17 | Genetic pathways that regulate ageing in model organisms | Nature | 2000 | 1,230 |
| 18 | IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response | Science | 2007 | 1,221 |
| 19 | Functional inactivation of genes by dominant negative mutations | Nature | 1987 | 1,212 |
| 20 | The role of cyclin synthesis and degradation in the control of maturation promoting factor activity | Nature | 1989 | 1,141 |
| 21 | An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen | Science | 2009 | 1,129 |
| 22 | Signaling Vascular Morphogenesis and Maintenance | Science | 1997 | 1,127 |
| 23 | Role of Histone H3 Lysine 27 Methylation in X Inactivation | Science | 2003 | 1,098 |
| 24 | Major nucleolar proteins shuttle between nucleus and cytoplasm | Cell | 1989 | 1,085 |
| 25 | Exportin 1 (Crm1p) Is an Essential Nuclear Export Factor | Cell | 1997 | 1,067 |
| 26 | MAP kinase pathways in yeast: For mating and more | Cell | 1995 | 1,023 |
| 27 | Constitutive and Regulated Secretion of Proteins | Annual Review of Cell Biology | 1987 | 976 |
| 28 | Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes | Nature | 2010 | 965 |
| 29 | Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling | Nature Genetics | 2001 | 906 |
| 30 | A structural role for hormone in the thyroid hormone receptor | Nature | 1995 | 905 |
| 31 | Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. | EMBO Journal | 1987 | 884 |
| 32 | Signals from the reproductive system regulate the lifespan of C. elegans | Nature | 1999 | 855 |
| 33 | Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins | Nature | 1986 | 836 |
| 34 | Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis | Science | 2000 | 833 |
| 35 | Control of the Selectivity of the Aquaporin Water Channel Family by Global Orientational Tuning | Science | 2002 | 833 |
| 36 | Nucleation of microtubule assembly by a γ-tubulin-containing ring complex | Nature | 1995 | 823 |
| 37 | EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy | Nature Methods | 2015 | 799 |
| 38 | Vertebrate genome evolution and the zebrafish gene map | Nature Genetics | 1998 | 792 |
| 39 | Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’ | Nature | 2011 | 781 |
| 40 | Microtubule assembly nucleated by isolated centrosomes | Nature | 1984 | 772 |
| 41 | Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane | Annual Review of Cell Biology | 1994 | 772 |
| 42 | Conformational variations in an infectious protein determine prion strain differences | Nature | 2004 | 747 |
| 43 | Dominoes and clocks: the union of two views of the cell cycle | Science | 1989 | 740 |
| 44 | Cyclin activation of p34cdc2 | Cell | 1990 | 730 |
| 45 | Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals | Current Opinion in Cell Biology | 2001 | 725 |
| 46 | mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2 | Cell | 1991 | 715 |
| 47 | The integrated stress response: From mechanism to disease | Science | 2020 | 715 |
| 48 | Nonlinear partial differential equations and applications: Microarray-based detection and genotyping of viral pathogens | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 713 |
| 49 | Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice | Journal of Clinical Investigation | 2000 | 704 |
| 50 | A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus | Diabetes | 1984 | 671 |
