| # | Title | Journal | Year | Citations |
|---|
| 1 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | Nature | 2020 | 3,542 |
| 2 | Global landscape of protein complexes in the yeast Saccharomyces cerevisiae | Nature | 2006 | 2,681 |
| 3 | Molecular mechanisms of nociception | Nature | 2001 | 2,141 |
| 4 | Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution | Science | 2014 | 1,567 |
| 5 | Actin-Based Cell Motility and Cell Locomotion | Cell | 1996 | 1,422 |
| 6 | A capsaicin-receptor homologue with a high threshold for noxious heat | Nature | 1999 | 1,414 |
| 7 | Computer Control of Microscopes Using µManager | Current Protocols in Molecular Biology | 2010 | 1,352 |
| 8 | Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response | Science | 2006 | 1,094 |
| 9 | Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 1,065 |
| 10 | Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 | PLoS Biology | 2009 | 973 |
| 11 | The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule | Molecular Microbiology | 2001 | 909 |
| 12 | Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis | Science | 2000 | 833 |
| 13 | Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds | Cell | 2015 | 809 |
| 14 | Therapeutic approaches to protein-misfolding diseases | Nature | 2003 | 787 |
| 15 | Conformational variations in an infectious protein determine prion strain differences | Nature | 2004 | 747 |
| 16 | Pungent products from garlic activate the sensory ion channel TRPA1 | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 740 |
| 17 | Mechanism and role of PDZ domains in signaling complex assembly | Journal of Cell Science | 2001 | 724 |
| 18 | The promise and peril of chemical probes | Nature Chemical Biology | 2015 | 698 |
| 19 | Mechanism and role of PDZ domains in signaling complex assembly | Journal of Cell Science | 2001 | 622 |
| 20 | A Brief History of Long-Term Potentiation | Neuron | 2017 | 602 |
| 21 | A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria | Cell | 2016 | 593 |
| 22 | Actin polymerization is induced by Arp 2/3 protein complex at the surface of Listeria monocytogenes | Nature | 1997 | 567 |
| 23 | The unfolded protein response signals through high-order assembly of Ire1 | Nature | 2009 | 565 |
| 24 | Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum | Science | 2011 | 559 |
| 25 | Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II | Nature Structural and Molecular Biology | 2012 | 556 |
| 26 | Synaptic Strength Regulated by Palmitate Cycling on PSD-95 | Cell | 2002 | 526 |
| 27 | Silent synapses and the emergence of a postsynaptic mechanism for LTP | Nature Reviews Neuroscience | 2008 | 519 |
| 28 | XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly | Cell | 1996 | 517 |
| 29 | Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons | Nature | 1997 | 504 |
| 30 | The cytoplasmic dynein transport machinery and its many cargoes | Nature Reviews Molecular Cell Biology | 2018 | 485 |
| 31 | Identification of PSD-95 Palmitoylating Enzymes | Neuron | 2004 | 483 |
| 32 | Allosteric effects of DNA on transcriptional regulators | Nature | 1998 | 476 |
| 33 | GPCRdb: an information system for G protein-coupled receptors | Nucleic Acids Research | 2016 | 472 |
| 34 | Stargazin modulates AMPA receptor gating and trafficking by distinct domains | Nature | 2005 | 447 |
| 35 | Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors | Nature | 1997 | 436 |
| 36 | Discovery of nitrate–CPK–NLP signalling in central nutrient–growth networks | Nature | 2017 | 425 |
| 37 | MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices | Nature Methods | 2019 | 421 |
| 38 | Rewiring of Genetic Networks in Response to DNA Damage | Science | 2010 | 408 |
| 39 | SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors | Nature Cell Biology | 2011 | 408 |
| 40 | Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles | Nature Chemical Biology | 2012 | 408 |
| 41 | A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity | Current Biology | 1998 | 394 |
| 42 | Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses | Neuron | 1996 | 382 |
| 43 | The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum | Molecular Cell | 2002 | 374 |
| 44 | A Critical Role for Amino-Terminal Glutamine/Asparagine Repeats in the Formation and Propagation of a Yeast Prion | Cell | 1998 | 365 |
| 45 | Force-Induced Bidirectional Stepping of Cytoplasmic Dynein | Cell | 2007 | 361 |
| 46 | Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics | Science | 2008 | 361 |
| 47 | Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor | Nature | 2016 | 358 |
| 48 | Epilepsy-Related Ligand/Receptor Complex LGI1 and ADAM22 Regulate Synaptic Transmission | Science | 2006 | 352 |
| 49 | Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4 | Plant Journal | 2006 | 352 |
| 50 | The 5-HT3Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors | Journal of Neuroscience | 2002 | 341 |
